"Dideoxyadenosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
| Descriptor ID |
D016048
|
| MeSH Number(s) |
D03.633.100.759.590.138.325.105 D13.570.230.229.105 D13.570.230.500.105 D13.570.583.138.325.105
|
| Concept/Terms |
Dideoxyadenosine- Dideoxyadenosine
- 2',3'-Dideoxyadenosine
- 2',3' Dideoxyadenosine
- ddA (Antiviral)
|
Below are MeSH descriptors whose meaning is more general than "Dideoxyadenosine".
Below are MeSH descriptors whose meaning is more specific than "Dideoxyadenosine".
This graph shows the total number of publications written about "Dideoxyadenosine" by people in this website by year, and whether "Dideoxyadenosine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dideoxyadenosine" by people in Profiles.
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2'-beta-fluoro-2',3'-dideoxyadenosine, lodenosine, in rhesus monkeys: plasma and cerebrospinal fluid pharmacokinetics and urinary disposition. Drug Metab Dispos. 1999 Oct; 27(10):1128-32.
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Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine. J Med Chem. 1997 Nov 21; 40(24):3969-73.
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Pharmacokinetics of dideoxypurine nucleoside analogs in plasma and cerebrospinal fluid of rhesus monkeys. Antimicrob Agents Chemother. 1995 Jun; 39(6):1259-64.
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Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine. Biochem Pharmacol. 1994 Jul 05; 48(1):11-14.
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Study of human immunodeficiency virus resistance to 2'-3'-dideoxyinosine and zidovudine in sequential isolates from pediatric patients on long-term therapy. J Infect Dis. 1993 Apr; 167(4):818-23.