Homogentisate 1,2-Dioxygenase
"Homogentisate 1,2-Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
| Descriptor ID |
D050560
|
| MeSH Number(s) |
D08.811.682.690.416.326
|
| Concept/Terms |
Homogentisate 1,2-Dioxygenase- Homogentisate 1,2-Dioxygenase
- 1,2-Dioxygenase, Homogentisate
- Homogentisate 1,2 Dioxygenase
- Homogentisic Acid Oxidase
- Acid Oxidase, Homogentisic
- Oxidase, Homogentisic Acid
- Homogentisate Oxygenase
- Oxygenase, Homogentisate
- Homogentisate Dioxygenase
- Dioxygenase, Homogentisate
- Homogentisate Oxidase
- Oxidase, Homogentisate
|
Below are MeSH descriptors whose meaning is more general than "Homogentisate 1,2-Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "Homogentisate 1,2-Dioxygenase".
This graph shows the total number of publications written about "Homogentisate 1,2-Dioxygenase" by people in this website by year, and whether "Homogentisate 1,2-Dioxygenase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Homogentisate 1,2-Dioxygenase" by people in Profiles.
-
In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice. Mol Ther. 2012 Oct; 20(10):1981-7.
-
Aneuploidy as a mechanism for stress-induced liver adaptation. J Clin Invest. 2012 Sep; 122(9):3307-15.
-
In vivo genetic selection of renal proximal tubules. Mol Ther. 2006 Jan; 13(1):49-58.