"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
|
| MeSH Number(s) |
D27.720.470.480
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 7 | 7 |
| 1995 | 0 | 12 | 12 |
| 1996 | 0 | 13 | 13 |
| 1997 | 0 | 16 | 16 |
| 1998 | 1 | 17 | 18 |
| 1999 | 0 | 18 | 18 |
| 2000 | 0 | 20 | 20 |
| 2001 | 1 | 20 | 21 |
| 2002 | 2 | 34 | 36 |
| 2003 | 0 | 38 | 38 |
| 2004 | 0 | 34 | 34 |
| 2005 | 0 | 35 | 35 |
| 2006 | 2 | 32 | 34 |
| 2007 | 0 | 22 | 22 |
| 2008 | 0 | 32 | 32 |
| 2009 | 2 | 25 | 27 |
| 2010 | 0 | 25 | 25 |
| 2011 | 1 | 22 | 23 |
| 2012 | 1 | 23 | 24 |
| 2013 | 1 | 18 | 19 |
| 2014 | 3 | 25 | 28 |
| 2015 | 0 | 12 | 12 |
| 2016 | 1 | 10 | 11 |
| 2017 | 1 | 15 | 16 |
| 2018 | 0 | 21 | 21 |
| 2019 | 1 | 13 | 14 |
| 2020 | 0 | 15 | 15 |
| 2021 | 1 | 18 | 19 |
| 2022 | 0 | 24 | 24 |
| 2023 | 0 | 19 | 19 |
| 2024 | 0 | 4 | 4 |
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Below are the most recent publications written about "Ligands" by people in Profiles.
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Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar KD. Nucleic Acids Res. 2024 Aug 12; 52(14):8039-8051.
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6-Formylindolo[3,2-b]carbazole, a potent ligand for the aryl hydrocarbon receptor, attenuates concanavalin-induced hepatitis by limiting T-cell activation and infiltration of proinflammatory CD11b+ Kupffer cells. J Leukoc Biol. 2024 05 29; 115(6):1070-1083.
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Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs. Front Immunol. 2024; 15:1330373.
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Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection. mBio. 2024 Mar 13; 15(3):e0340823.
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Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology. Mol Pharmacol. 2024 Feb 15; 105(3):260-271.
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Myotubularin-related protein 6 is an ion channel-associated pro-leishmanial phosphatase. Int Immunopharmacol. 2024 Mar 10; 129:111644.
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Final analysis of phase II results with cemiplimab in metastatic basal cell carcinoma after hedgehog pathway inhibitors. Ann Oncol. 2024 Feb; 35(2):221-228.
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ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA-Encoded Libraries. J Am Chem Soc. 2023 11 22; 145(46):25283-25292.
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Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas. Nat Commun. 2023 10 07; 14(1):6279.
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Clinical Pharmacology Profile of AMG?119, the First Chimeric Antigen Receptor?T (CAR-T) Cell Therapy Targeting Delta-Like Ligand?3 (DLL3), in Patients with Relapsed/Refractory Small Cell Lung Cancer (SCLC). J Clin Pharmacol. 2024 03; 64(3):362-370.