"Alanine Racemase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC 5.1.1.1.
| Descriptor ID |
D000411
|
| MeSH Number(s) |
D08.811.399.894.200.200
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Alanine Racemase".
Below are MeSH descriptors whose meaning is more specific than "Alanine Racemase".
This graph shows the total number of publications written about "Alanine Racemase" by people in this website by year, and whether "Alanine Racemase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Alanine Racemase" by people in Profiles.
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Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630. Acta Crystallogr D Biol Crystallogr. 2014 Jul; 70(Pt 7):1922-33.
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Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones. Biochem Pharmacol. 2013 Jul 15; 86(2):222-30.
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New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosis. PLoS One. 2011; 6(5):e20374.
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The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design. BMC Microbiol. 2011 May 25; 11:116.
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Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames). BMC Struct Biol. 2009 Aug 20; 9:53.
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The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine. J Bacteriol. 2007 Nov; 189(22):8381-6.
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Purification and preliminary crystallization of alanine racemase from Streptococcus pneumoniae. BMC Microbiol. 2007 May 17; 7:40.
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The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. Biochemistry. 2005 Feb 08; 44(5):1471-81.
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Crystal structure at 1.45 A resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. Biochemistry. 2003 Dec 23; 42(50):14752-61.
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N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. J Antibiot (Tokyo). 2003 Feb; 56(2):160-8.