Neural Tube Defects

"Neural Tube Defects" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)

Descriptor ID	D009436
MeSH Number(s)	C10.500.680 C16.131.666.680
Concept/Terms	Neural Tube Defects Neural Tube Defects Defect, Neural Tube Defects, Neural Tube Neural Tube Defect Developmental Neural Tube Defects Neural Tube Developmental Defects Developmental Defects, Neural Tube Craniorachischisis Craniorachischisis Craniorachischises Diastematomyelia Diastematomyelia Diastematomyelias Tethered Cord Syndrome Tethered Cord Syndrome Tethered Cord Syndromes Occult Spinal Dysraphism Sequence Tethered Spinal Cord Syndrome Occult Spinal Dysraphism Dysraphism, Occult Spinal Dysraphisms, Occult Spinal Occult Spinal Dysraphisms Spinal Dysraphism, Occult Spinal Dysraphisms, Occult Iniencephaly Iniencephaly Iniencephalies Neurenteric Cyst Neurenteric Cyst Cyst, Neurenteric Cysts, Neurenteric Neurenteric Cysts Neuroenteric Cyst Cyst, Neuroenteric Cysts, Neuroenteric Neuroenteric Cysts Spinal Cord Myelodysplasia Spinal Cord Myelodysplasia Myelodysplasia, Spinal Cord Myelodysplasias, Spinal Cord Spinal Cord Myelodysplasias Acrania Acrania Acranias Exencephaly Exencephaly Exencephalies

Below are MeSH descriptors whose meaning is more general than "Neural Tube Defects".

Diseases [C]
Nervous System Diseases [C10]
Nervous System Malformations [C10.500]
Neural Tube Defects [C10.500.680]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Nervous System Malformations [C16.131.666]
Neural Tube Defects [C16.131.666.680]

Below are MeSH descriptors whose meaning is related to "Neural Tube Defects".

Below are MeSH descriptors whose meaning is more specific than "Neural Tube Defects".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neural Tube Defects" by people in this website by year, and whether "Neural Tube Defects" was a major or minor topic of these publications.

Bar chart showing 160 publications over 29 distinct years, with a maximum of 13 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1991	2	0	2
1992	0	1	1
1993	1	0	1
1995	1	1	2
1996	5	0	5
1997	3	1	4
1998	2	0	2
1999	2	0	2
2000	5	0	5
2001	6	1	7
2002	4	3	7
2003	11	0	11
2004	4	0	4
2005	2	3	5
2006	3	3	6
2007	3	1	4
2008	5	2	7
2009	4	3	7
2010	7	3	10
2011	4	1	5
2012	5	2	7
2013	8	2	10
2014	10	2	12
2015	0	1	1
2016	1	1	2
2017	4	2	6
2018	10	3	13
2019	7	3	10
2020	2	0	2

Below are the most recent publications written about "Neural Tube Defects" by people in Profiles.

Tian T, Lei Y, Chen Y, Karki M, Jin L, Finnell RH, Wang L, Ren A. Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects. Hum Genet. 2020 Oct; 139(10):1299-1314.

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Wei J, Wang C, Yin S, Pi X, Jin L, Li Z, Liu J, Wang L, Yin C, Ren A. Concentrations of rare earth elements in maternal serum during pregnancy and risk for fetal neural tube defects. Environ Int. 2020 04; 137:105542.

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López-Escobar B, Wlodarczyk BJ, Caro-Vega J, Lin Y, Finnell RH, Ybot-González P. The interaction of maternal diabetes with mutations that affect folate metabolism and how they affect the development of neural tube defects in mice. Dev Dyn. 2019 10; 248(10):900-917.

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Kousa YA, Zhu H, Fakhouri WD, Lei Y, Kinoshita A, Roushangar RR, Patel NK, Agopian AJ, Yang W, Leslie EJ, Busch TD, Mansour TA, Li X, Smith AL, Li EB, Sharma DB, Williams TJ, Chai Y, Amendt BA, Liao EC, Mitchell LE, Bassuk AG, Gregory S, Ashley-Koch A, Shaw GM, Finnell RH, Schutte BC. The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Hum Mol Genet. 2019 05 15; 28(10):1726-1737.

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Sadrameli SS, Chu JK, Chan TM, Steele WJ, Curry DJ, Lam SK. Minimally Invasive Tubular Tethered Cord Release in the Pediatric Population. World Neurosurg. 2019 Aug; 128:e912-e917.

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Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw GM, Agopian AJ. Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring. Mol Genet Genomic Med. 2019 06; 7(6):e688.

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Manrique S, Maiz N, García I, Pascual M, Perera R, Arévalo S, Giné C, Molino JA, López M, Blanco D, de Nadal M, Carreras E. Maternal anaesthesia in open and fetoscopic surgery of foetal open spinal neural tube defects: A retrospective cohort study. Eur J Anaesthesiol. 2019 03; 36(3):175-184.

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Zarutskie A, Guimaraes C, Yepez M, Torres P, Shetty A, Sangi-Haghpeykar H, Lee W, Espinoza J, Shamshirsaz AA, Nassr A, Belfort MA, Whitehead WE, Sanz Cortes M. Prenatal brain imaging for predicting need for postnatal hydrocephalus treatment in fetuses that had neural tube defect repair in utero. Ultrasound Obstet Gynecol. 2019 Mar; 53(3):324-334.

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Sanz Cortes M, Davila I, Torres P, Yepez M, Lee W, Guimaraes CV, Sangi-Haghpeykar H, Whitehead WE, Castillo J, Nassr AA, Espinoza J, Shamshirsaz AA, Belfort MA. Does fetoscopic or open repair for spina bifida affect fetal and postnatal growth? Ultrasound Obstet Gynecol. 2019 Mar; 53(3):314-323.

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Sanz Cortes M, Castro E, Sharhan D, Torres P, Yepez M, Espinoza J, Shamshirsaz AA, Nassr AA, Popek E, Whitehead W, Belfort MA. Amniotic membrane and placental histopathological findings after open and fetoscopic prenatal neural tube defect repair. Prenat Diagn. 2019 03; 39(4):269-279.

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