GIULIO DRAETTA to Enzyme Inhibitors
This is a "connection" page, showing publications GIULIO DRAETTA has written about Enzyme Inhibitors.
Connection Strength
0.416
-
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 10 28; 64(20):15141-15169.
Score: 0.114
-
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. J Med Chem. 2020 11 12; 63(21):12957-12977.
Score: 0.107
-
Identification of potent and selective MTH1 inhibitors. Bioorg Med Chem Lett. 2016 Mar 15; 26(6):1503-1507.
Score: 0.077
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007 Aug 06; 204(8):1813-24.
Score: 0.043
-
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol. 2007 Feb; 14(2):209-19.
Score: 0.041
-
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nat Commun. 2021 07 30; 12(1):4626.
Score: 0.028
-
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995 Aug 04; 269(5224):682-5.
Score: 0.005