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CINDY FARACH-CARSON

TitleR & D Looney Professor
InstitutionRice University
DepartmentBioSciences at Rice
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    Other Positions
    TitleAdjunct Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    2016Presidential Mentoring Award, Rice University
    2010AAAS Member; Biological Sciences , AAAS

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang B, Lai X, Price C, Thompson WR, Li W, Quabili TR, Tseng WJ, Liu XS, Zhang H, Pan J, Kirn-Safran CB, Farach-Carson MC, Wang L. Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. J Bone Miner Res. 2014 Apr; 29(4):878-91. PMID: 24115222.
      View in: PubMed
    2. Xu X, Sabanayagam CR, Harrington DA, Farach-Carson MC, Jia X. A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics. Biomaterials. 2014 Mar; 35(10):3319-30. PMID: 24447463.
      View in: PubMed
    3. Farach-Carson MC, Warren CR, Harrington DA, Carson DD. Border patrol: insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders. Matrix Biol. 2014 Feb; 34:64-79. PMID: 24001398.
      View in: PubMed
    4. Pradhan-Bhatt S, Harrington DA, Duncan RL, Farach-Carson MC, Jia X, Witt RL. A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland. Laryngoscope. 2014 Feb; 124(2):456-61. PMID: 23832678.
      View in: PubMed
    5. Xu X, Jha AK, Harrington DA, Farach-Carson MC, Jia X. Hyaluronic Acid-Based Hydrogels: from a Natural Polysaccharide to Complex Networks. Soft Matter. 2012; 8(12):3280-3294. PMID: 22419946.
      View in: PubMed
    6. Lukianova-Hleb EY, Oginsky AO, Shenefelt DL, Drezek RA, Hafner JH, Farach-Carson MC, Lapotko DO. Rainbow Plasmonic Nanobubbles: Synergistic Activation of Gold Nanoparticle Clusters. J Nanomed Nanotechnol. 2011 Jan 01; 2(104):1-8. PMID: 21804947.
      View in: PubMed
    7. Wang X, Gurski LA, Zhong S, Xu X, Pochan DJ, Farach-Carson MC, Jia X. Amphiphilic block co-polyesters bearing pendant cyclic ketal groups as nanocarriers for controlled release of camptothecin. J Biomater Sci Polym Ed. 2011; 22(10):1275-98. PMID: 20594408.
      View in: PubMed
    8. Jha AK, Malik MS, Farach-Carson MC, Duncan RL, Jia X. Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks. Soft Matter. 2010 Jun 15; 6(20):5045-5055. PMID: 20936090.
      View in: PubMed
    9. O'Connor RD, Zayzafoon M, Farach-Carson MC, Schanen NC. Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome. Bone. 2009 Aug; 45(2):346-56. PMID: 19414073.
      View in: PubMed
    10. Brown AJ, Alicknavitch M, D'Souza SS, Daikoku T, Kirn-Safran CB, Marchetti D, Carson DD, Farach-Carson MC. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008 Oct; 43(4):689-99. PMID: 18589009.
      View in: PubMed
    11. Datta MW, Hernandez AM, Schlicht MJ, Kahler AJ, DeGueme AM, Dhir R, Shah RB, Farach-Carson C, Barrett A, Datta S. Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. Mol Cancer. 2006 Mar 01; 5:9. PMID: 16507112.
      View in: PubMed
    12. Yang WD, Gomes RR, Alicknavitch M, Farach-Carson MC, Carson DD. Perlecan domain I promotes fibroblast growth factor 2 delivery in collagen I fibril scaffolds. Tissue Eng. 2005 Jan-Feb; 11(1-2):76-89. PMID: 15738663.
      View in: PubMed
    13. Nemere I, Farach-Carson MC, Rohe B, Sterling TM, Norman AW, Boyan BD, Safford SE. Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7392-7. PMID: 15123837.
      View in: PubMed
    14. Bergh JJ, Shao Y, Akanbi K, Farach-Carson MC. Rodent osteoblastic cells express voltage-sensitive calcium channels lacking a gamma subunit. Calcif Tissue Int. 2003 Nov; 73(5):502-10. PMID: 12958687.
      View in: PubMed
    15. Farach-Carson MC, Nemere I. Membrane receptors for vitamin D steroid hormones: potential new drug targets. Curr Drug Targets. 2003 Jan; 4(1):67-76. PMID: 12528991.
      View in: PubMed
    16. Gomes RR, Farach Carson MC, Carson DD. Perlecan-stimulated nodules undergo chondrogenic maturation in response to rhBMP-2 treatment in vitro. Connect Tissue Res. 2003; 44 Suppl 1:196-201. PMID: 12952197.
      View in: PubMed
    17. Gomes R, Kirn-Safran C, Farach-Carson MC, Carson DD. Perlecan: an important component of the cartilage pericellular matrix. J Musculoskelet Neuronal Interact. 2002 Dec; 2(6):511-6. PMID: 15758379.
      View in: PubMed
    18. Ta TV, Baraniak D, Julian J, Korostoff J, Carson DD, Farach-Carson MC. Heparan sulfate interacting protein (HIP/L29) negatively regulates growth responses to basic fibroblast growth factor in gingival fibroblasts. J Dent Res. 2002 Apr; 81(4):247-52. PMID: 12097308.
      View in: PubMed
    19. Kiefer JA, Farach-Carson MC. Type I collagen-mediated proliferation of PC3 prostate carcinoma cell line: implications for enhanced growth in the bone microenvironment. Matrix Biol. 2001 Nov; 20(7):429-37. PMID: 11691583.
      View in: PubMed
    20. Li W, Farach-Carson MC. Parathyroid hormone-stimulated resorption in calvaria cultured in serum-free medium is enhanced by the calcium-mobilizing activity of 1,25-dihydroxyvitamin D(3). Bone. 2001 Sep; 29(3):231-5. PMID: 11557366.
      View in: PubMed
    21. Farach-Carson MC. Bioactive analogs that simulate subsets of biological activities of 1alpha,25(OH)(2)D(3) in osteoblasts. Steroids. 2001 Mar-May; 66(3-5):357-61. PMID: 11179744.
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    22. Edlund M, Miyamoto T, Sikes RA, Ogle R, Laurie GW, Farach-Carson MC, Otey CA, Zhau HE, Chung LW. Integrin expression and usage by prostate cancer cell lines on laminin substrata. Cell Growth Differ. 2001 Feb; 12(2):99-107. PMID: 11243469.
      View in: PubMed
    23. Liu R, Xu Y, Farach-Carson MC, Vogel JJ, Karin NJ. 1,25 dihydroxyvitamin D(3) activates sphingomyelin turnover in ROS17/2.8 osteosarcoma cells without sphingolipid-induced changes in cytosolic Ca(2+). Biochem Biophys Res Commun. 2000 Jun 24; 273(1):95-100. PMID: 10873570.
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    24. Liu R, Li W, Karin NJ, Bergh JJ, Adler-Storthz K, Farach-Carson MC. Ribozyme ablation demonstrates that the cardiac subtype of the voltage-sensitive calcium channel is the molecular transducer of 1, 25-dihydroxyvitamin D(3)-stimulated calcium influx in osteoblastic cells. J Biol Chem. 2000 Mar 24; 275(12):8711-8. PMID: 10722713.
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    25. Lecrone V, Li W, Devoll RE, Logothetis C, Farach-Carson MC. Calcium signals in prostate cancer cells: specific activation by bone-matrix proteins. Cell Calcium. 2000 Jan; 27(1):35-42. PMID: 10726209.
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    26. Thalmann GN, Sikes RA, Devoll RE, Kiefer JA, Markwalder R, Klima I, Farach-Carson CM, Studer UE, Chung LW. Osteopontin: possible role in prostate cancer progression. Clin Cancer Res. 1999 Aug; 5(8):2271-7. PMID: 10473115.
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    27. French MM, Smith SE, Akanbi K, Sanford T, Hecht J, Farach-Carson MC, Carson DD. Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro. J Cell Biol. 1999 May 31; 145(5):1103-15. PMID: 10352025.
      View in: PubMed
    28. Devoll RE, Li W, Woods KV, Pinero GJ, Butler WT, Farach-Carson MC, Happonen RP. Osteopontin (OPN) distribution in premalignant and malignant lesions of oral epithelium and expression in cell lines derived from squamous cell carcinoma of the oral cavity. J Oral Pathol Med. 1999 Mar; 28(3):97-101. PMID: 10069535.
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    29. Safran JB, Butler WT, Farach-Carson MC. Modulation of osteopontin post-translational state by 1, 25-(OH)2-vitamin D3. Dependence on Ca2+ influx. J Biol Chem. 1998 Nov 06; 273(45):29935-41. PMID: 9792712.
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    30. Li W, Duncan RL, Karin NJ, Farach-Carson MC. 1,25 (OH)2D3 enhances PTH-induced Ca2+ transients in preosteoblasts by activating L-type Ca2+ channels. Am J Physiol. 1997 Sep; 273(3 Pt 1):E599-605. PMID: 9316451.
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    31. Norman AW, Okamura WH, Hammond MW, Bishop JE, Dormanen MC, Bouillon R, van Baelen H, Ridall AL, Daane E, Khoury R, Farach-Carson MC. Comparison of 6-s-cis- and 6-s-trans-locked analogs of 1alpha,25-dihydroxyvitamin D3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis- nor 6-s-trans-locked analogs are preferred for genomic biological responses. Mol Endocrinol. 1997 Sep; 11(10):1518-31. PMID: 9280067.
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    32. Devoll RE, Pinero GJ, Appelbaum ER, Dul E, Troncoso P, Butler WT, Farach-Carson MC. Improved immunohistochemical staining of osteopontin (OPN) in paraffin-embedded archival bone specimens following antigen retrieval: anti-human OPN antibody recognizes multiple molecular forms. Calcif Tissue Int. 1997 Apr; 60(4):380-6. PMID: 9075637.
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    33. Snyder WR, Hoover J, Khoury R, Farach-Carson MC. Effect of agents used in perforation repair on osteoblastic cells. J Endod. 1997 Mar; 23(3):158-61. PMID: 9594755.
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    34. Meszaros JG, Farach-Carson MC. Assay of direct effect of 1,25-dihydroxyvitamin D3 on calcium ion influx into cultured osteoblasts. Methods Enzymol. 1997; 282:236-43. PMID: 9330292.
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    35. Meszaros JG, Karin NJ, Akanbi K, Farach-Carson MC. Down-regulation of L-type Ca2+ channel transcript levels by 1,25-dihyroxyvitamin D3. Osteoblastic cells express L-type alpha1C Ca2+ channel isoforms. J Biol Chem. 1996 Dec 20; 271(51):32981-5. PMID: 8955142.
      View in: PubMed
    36. Meszaros JG, Karin NJ, Farach-Carson MC. Voltage-sensitive calcium channels in osteoblasts: mediators of plasma membrane signalling events. Connect Tissue Res. 1996; 35(1-4):107-11. PMID: 9084649.
      View in: PubMed
    37. Norman AW, Bishop JE, Collins ED, Seo EG, Satchell DP, Dormanen MC, Zanello SB, Farach-Carson MC, Bouillon R, Okamura WH. Differing shapes of 1 alpha,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: a status report. J Steroid Biochem Mol Biol. 1996 Jan; 56(1-6 Spec No):13-22. PMID: 8603033.
      View in: PubMed
    38. Liu R, Farach-Carson MC, Karin NJ. Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. Biochem Biophys Res Commun. 1995 Sep 14; 214(2):676-84. PMID: 7677781.
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    39. Khoury RS, Weber J, Farach-Carson MC. Vitamin D metabolites modulate osteoblast activity by Ca+2 influx-independent genomic and Ca+2 influx-dependent nongenomic pathways. J Nutr. 1995 06; 125(6 Suppl):1699S-1703S. PMID: 7782930.
      View in: PubMed
    40. Pinero GJ, Farach-Carson MC, Devoll RE, Aubin JE, Brunn JC, Butler WT. Bone matrix proteins in osteogenesis and remodelling in the neonatal rat mandible as studied by immunolocalization of osteopontin, bone sialoprotein, alpha 2HS-glycoprotein and alkaline phosphatase. Arch Oral Biol. 1995 Feb; 40(2):145-55. PMID: 7794128.
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    41. Khoury R, Ridall AL, Norman AW, Farach-Carson MC. Target gene activation by 1,25-dihydroxyvitamin D3 in osteosarcoma cells is independent of calcium influx. Endocrinology. 1994 Dec; 135(6):2446-53. PMID: 7988430.
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    42. Yue TL, McKenna PJ, Ohlstein EH, Farach-Carson MC, Butler WT, Johanson K, McDevitt P, Feuerstein GZ, Stadel JM. Osteopontin-stimulated vascular smooth muscle cell migration is mediated by beta 3 integrin. Exp Cell Res. 1994 Oct; 214(2):459-64. PMID: 7925641.
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    43. Bronckers AL, Farach-Carson MC, Van Waveren E, Butler WT. Immunolocalization of osteopontin, osteocalcin, and dentin sialoprotein during dental root formation and early cementogenesis in the rat. J Bone Miner Res. 1994 Jun; 9(6):833-41. PMID: 8079659.
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    44. van Dijk S, D'Errico JA, Somerman MJ, Farach-Carson MC, Butler WT. Evidence that a non-RGD domain in rat osteopontin is involved in cell attachment. J Bone Miner Res. 1993 Dec; 8(12):1499-506. PMID: 8304052.
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    45. Farach-Carson MC, Abe J, Nishii Y, Khoury R, Wright GC, Norman AW. 22-Oxacalcitriol: dissection of 1,25(OH)2D3 receptor-mediated and Ca2+ entry-stimulating pathways. Am J Physiol. 1993 Nov; 265(5 Pt 2):F705-11. PMID: 8238551.
      View in: PubMed
    46. Norman AW, Bouillon R, Farach-Carson MC, Bishop JE, Zhou LX, Nemere I, Zhao J, Muralidharan KR, Okamura WH. Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3. J Biol Chem. 1993 Sep 25; 268(27):20022-30. PMID: 8397195.
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    47. Norman AW, Okamura WH, Farach-Carson MC, Allewaert K, Branisteanu D, Nemere I, Muralidharan KR, Bouillon R. Structure-function studies of 1,25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1,25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses. J Biol Chem. 1993 Jul 05; 268(19):13811-9. PMID: 8390978.
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    48. Ross FP, Chappel J, Alvarez JI, Sander D, Butler WT, Farach-Carson MC, Mintz KA, Robey PG, Teitelbaum SL, Cheresh DA. Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. J Biol Chem. 1993 May 05; 268(13):9901-7. PMID: 8486670.
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    49. McKee MD, Farach-Carson MC, Butler WT, Hauschka PV, Nanci A. Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and alpha 2HS-glycoprotein) proteins in rat bone. J Bone Miner Res. 1993 Apr; 8(4):485-96. PMID: 8475798.
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    50. Butler WT, Bhown M, Brunn JC, D'Souza RN, Farach-Carson MC, Happonen RP, Schrohenloher RE, Seyer JM, Somerman MJ, Foster RA, et al. Isolation, characterization and immunolocalization of a 53-kDal dentin sialoprotein (DSP). Matrix. 1992 Nov; 12(5):343-51. PMID: 1484502.
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    51. Ritter NM, Farach-Carson MC, Butler WT. Evidence for the formation of a complex between osteopontin and osteocalcin. J Bone Miner Res. 1992 Aug; 7(8):877-85. PMID: 1442202.
      View in: PubMed
    52. Norman AW, Nemere I, Zhou LX, Bishop JE, Lowe KE, Maiyar AC, Collins ED, Taoka T, Sergeev I, Farach-Carson MC. 1,25(OH)2-vitamin D3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways. J Steroid Biochem Mol Biol. 1992 Mar; 41(3-8):231-40. PMID: 1314073.
      View in: PubMed
    53. D'Souza RN, Bronckers AL, Happonen RP, Doga DA, Farach-Carson MC, Butler WT. Developmental expression of a 53 KD dentin sialoprotein in rat tooth organs. J Histochem Cytochem. 1992 Mar; 40(3):359-66. PMID: 1552175.
      View in: PubMed
    54. Farach-Carson MC, Wright GC, Butler WT. Improved binding of acidic bone matrix proteins to cationized filters during solid phase assays. Bone Miner. 1992 Jan; 16(1):1-9. PMID: 1537006.
      View in: PubMed
    55. Farach-Carson MC, Sergeev I, Norman AW. Nongenomic actions of 1,25-dihydroxyvitamin D3 in rat osteosarcoma cells: structure-function studies using ligand analogs. Endocrinology. 1991 Oct; 129(4):1876-84. PMID: 1655387.
      View in: PubMed
    56. Mizuno M, Farach-Carson MC, Pinero GJ, Fujisawa R, Brunn JC, Seyer JM, Bousfield GR, Mark MP, Butler WT. Identification of the rat bone 60K acidic glycoprotein as alpha 2HS-glycoprotein. Bone Miner. 1991 Apr; 13(1):1-21. PMID: 2065215.
      View in: PubMed
    57. Chan JC, Scanlon M, Denhardt DT, Singh K, Mukherjee BB, Farach-Carson MC, Butler WT. Immunochemical comparison of transformation-associated protein and secreted phosphoprotein. Int J Cancer. 1990 Nov 15; 46(5):864-70. PMID: 2228315.
      View in: PubMed
    58. Farach-Carson MC, Carson DD, Collier JL, Lennarz WJ, Park HR, Wright GC. A calcium-binding, asparagine-linked oligosaccharide is involved in skeleton formation in the sea urchin embryo. J Cell Biol. 1989 Sep; 109(3):1289-99. PMID: 2475510.
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    59. Caffrey JM, Farach MC. A monoclonal antibody specifically modulates dihydropyridine-sensitive calcium current in BC3H1 myocytes. Mol Pharmacol. 1988 Oct; 34(4):518-26. PMID: 2845251.
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    60. Farach MC, Tang JP, Decker GL, Carson DD. Differential effects of p-nitrophenyl-D-xylosides on mouse blastocysts and uterine epithelial cells. Biol Reprod. 1988 Sep; 39(2):443-55. PMID: 3179390.
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    61. Farach MC, Tang JP, Decker GL, Carson DD. Heparin/heparan sulfate is involved in attachment and spreading of mouse embryos in vitro. Dev Biol. 1987 Oct; 123(2):401-10. PMID: 2958379.
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    62. Farach MC, Valdizan M, Park HR, Decker GL, Lennarz WJ. Developmental expression of a cell-surface protein involved in calcium uptake and skeleton formation in sea urchin embryos. Dev Biol. 1987 Aug; 122(2):320-31. PMID: 3297856.
      View in: PubMed
    63. Carson DD, Farach MC, Earles DS, Decker GL, Lennarz WJ. A monoclonal antibody inhibits calcium accumulation and skeleton formation in cultured embryonic cells of the sea urchin. Cell. 1985 Jun; 41(2):639-48. PMID: 3986913.
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    64. Martinez-Carrion M, Gonzalez-Ros JM, Mattingly JR, Ferragut JA, Farach MC, Donnelly D. Fluorescence probes for the study of acetylcholine receptor function. Biophys J. 1984 Jan; 45(1):141-3. PMID: 19431543.
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    65. Soler G, Farach MC, Farach HA, Mattingly JR, Martinez-Carrion M. Reductive methylation as a probe of the heat-labile alpha-bungarotoxin-acetylcholine receptor membrane complex: evidence for surface interactions. Arch Biochem Biophys. 1983 Sep; 225(2):872-8. PMID: 6625612.
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    66. Gonzalez-Ros JM, Farach MC, Martinez-Carrion M. Ligand-induced effects at regions of acetylcholine receptor accessible to membrane lipids. Biochemistry. 1983 Aug 02; 22(16):3807-11. PMID: 6615803.
      View in: PubMed
    67. Farach MC, Martinez-Carrion M. A differential scanning calorimetry study of acetylcholine receptor-rich membranes from Torpedo californica. J Biol Chem. 1983 Apr 10; 258(7):4166-70. PMID: 6833247.
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    68. Farach MC, Mihovilovic M, Paraschos A, Martinez-Carrion M. Effect of anti-acetylcholine receptor Fab fragments from goats on functional membrane-bound receptor. Arch Biochem Biophys. 1982 Mar; 214(1):140-54. PMID: 7081993.
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    69. Mong FS, Farach MC, Martinez-Carrion M. Pattern of acetylcholine receptor activity during regeneration of free muscle transplants of rats. J Neurosci Res. 1982; 8(1):27-33. PMID: 7175977.
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    70. Gonzalez-Ros JM, Paraschos A, Farach MC, Martinez-Carrion M. Characterization of acetylcholine receptor isolated from Torpedo californica electroplax through the use of an easily removable detergent, beta-D-octylglucopyranoside. Biochim Biophys Acta. 1981 May 06; 643(2):407-20. PMID: 7225389.
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