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InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

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    Collapse Biography 
    Collapse awards and honors
    2016 - 2021Individual Investigator Research Award for Cancer in Children and Adolescent, CPRIT
    2015 - 2018Breast Cancer Breakthrough Award, Department of Defense
    2014 - 2017Bridging the Gap Early Translational Award, CPRIT

    Collapse Overview 
    Collapse keywords
    Cancer biology, Chromosomal segregation, Aneuploidy, Mouse models of cancer, Cohesin and Separase

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zhang N, Pati D. Biology and insights into the role of cohesin protease separase in human malignancies. Biol Rev Camb Philos Soc. 2017 Feb 08. PMID: 28177203.
      View in: PubMed
    2. Do HT, Zhang N, Pati D, Gilbertson SR. Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 2016 Sep 15; 26(18):4446-50. PMID: 27530289.
      View in: PubMed
    3. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. Journal of Clinical Investigation. 2015; 3(125):1147-62.
    4. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015 Mar 2; 125(3):1147-62. PMID: 25664850; PMCID: PMC4362236.
    5. Zhang N, Pati D. C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion. Cell Cycle. 2015; 14(6):820-6. PMID: 25608232; PMCID: PMC4614265.
    6. Mukherjee, M, Ge, G., Zhang N, Edwards D, Sumazin, P., Sharan, S, Rao PH, Medina D, Pati D. . MMTV-Espl1 Transgenic Mice Develop Aneuploid, Estrogen Receptor Alpha (ERa)-Positive Mammary Adenocarcinomas. Oncogene. 2014; 48(33):5511-22.
    7. Mukherjee M, Byrd T, Brawley VS, Bielamowicz K, Li XN, Merchant F, Maitra S, Sumazin P, Fuller G, Kew Y, Sun D, Powell SZ, Ahmed N, Zhang N, Pati D. Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. J Neurooncol. 2014 Aug; 119(1):27-35. PMID: 24792645; PMCID: PMC4160150.
    8. Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC and Pati D. Identification and characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J. Biomolecular Screening. 2014; 6(19):878-889.
    9. Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC, Pati D. Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J Biomol Screen. 2014 Jul; 19(6):878-89. PMID: 24525869.
      View in: PubMed
    10. Shete A, Rao P, Pati D, Merchant F. Spatial quantitation of FISH signals in diploid versus aneuploid nuclei. Cytometry A. 2014 Apr; 85(4):339-52. PMID: 24347051; PMCID: PMC3972278.
    11. Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27; 33(48):5511-22. PMID: 24276237; PMCID: PMC4032816.
    12. Zhang N, Jiang Y, Mao Q, Demeler B, Tao YJ, Pati D. Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. PLoS One. 2013; 8(7):e69458. PMID: 23874961; PMCID: PMC3709894.
    13. Pati D and Zhang N. SEPARASE INHIBITORS AND USES THEREOF . 2013.
    14. Zhang, N. and Pati, D. . Oncology. Path to cancer via Cohesin. 2013.
    15. Panigrahi AK, Pati D. Higher-order orchestration of hematopoiesis: is cohesin a new player? Exp Hematol. 2012 Dec; 40(12):967-73. PMID: 23022223; PMCID: PMC3595174.
    16. Zhang N, Pati D. Sororin is a master regulator of sister chromatid cohesion and separation. Cell Cycle. 2012 Jun 1; 11(11):2073-83. PMID: 22580470; PMCID: PMC3368859.
    17. Panigrahi AK, Zhang N, Otta SK, Pati D. A cohesin-RAD21 interactome. Biochem J. 2012 Mar 15; 442(3):661-70. PMID: 22145905.
      View in: PubMed
    18. Zhang N, Panigrahi AK, Mao Q, Pati D. Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion. J Biol Chem. 2011 Dec 2; 286(48):41826-37. PMID: 21987589; PMCID: PMC3310079.
    19. Panigrahi AK, Zhang N, Mao Q, Pati D. Calpain-1 cleaves Rad21 to promote sister chromatid separation. Mol Cell Biol. 2011 Nov; 31(21):4335-47. PMID: 21876002; PMCID: PMC3209327.
    20. Mukherjee M, Ge G, Zhang N, Huang E, Nakamura LV, Minor M, Fofanov V, Rao PH, Herron A, Pati D. Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice. PLoS One. 2011; 6(7):e22167. PMID: 21799785; PMCID: PMC3143119.
    21. Horton TM, Jenkins G, Pati D, Zhang L, Dolan ME, Ribes-Zamora A, Bertuch AA, Blaney SM, Delaney SL, Hegde M, Berg SL. Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity. Mol Cancer Ther. 2009 Aug; 8(8):2232-42. PMID: 19671751; PMCID: PMC3741063.
    22. Basu D, Zhang N, Panigrahi AK, Horton TM, Pati D. Development and validation of a fluorogenic assay to measure separase enzyme activity. Anal Biochem. 2009 Sep 15; 392(2):133-8. PMID: 19497291; PMCID: PMC2713383.
    23. Meyer R, Fofanov V, Panigrahi A, Merchant F, Zhang N, Pati D. Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. Clin Cancer Res. 2009 Apr 15; 15(8):2703-10. PMID: 19351757; PMCID: PMC2718850.
    24. Zhang N, Pati D. Handcuff for sisters: a new model for sister chromatid cohesion. Cell Cycle. 2009 Feb 1; 8(3):399-402. PMID: 19177018; PMCID: PMC2689371.
    25. Panigrahi AK, Pati D. Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer. Crit Rev Oncol Hematol. 2009 Dec; 72(3):181-93. PMID: 19162508; PMCID: PMC2783576.
    26. Zhang N, Kuznetsov SG, Sharan SK, Li K, Rao PH, Pati D. A handcuff model for the cohesin complex. J Cell Biol. 2008 Dec 15; 183(6):1019-31. PMID: 19075111; PMCID: PMC2600748.
    27. Pati D. Oncogenic activity of separase. Cell Cycle. 2008 Nov 15; 7(22):3481-2. PMID: 19001849; PMCID: PMC2613011.
    28. Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):13033-8. PMID: 18728194; PMCID: PMC2529090.
    29. Lu XY, Lu Y, Zhao YJ, Jaeweon K, Kang J, Xiao-Nan L, Ge G, Meyer R, Perlaky L, Hicks J, Chintagumpala M, Cai WW, Ladanyi M, Gorlick R, Lau CC, Pati D, Sheldon M, Rao PH. Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. Mol Cancer Res. 2008 Jun; 6(6):937-46. PMID: 18567798; PMCID: PMC2693718.
    30. Horton TM, Pati D, Plon SE, Thompson PA, Bomgaars LR, Adamson PC, Ingle AM, Wright J, Brockman AH, Paton M, Blaney SM. A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study. Clin Cancer Res. 2007 Mar 1; 13(5):1516-22. PMID: 17332297.
      View in: PubMed
    31. Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26; 176(5):581-92. PMID: 17312021; PMCID: PMC2064017.
    32. Zhang, N., Pradhan, S, Jena, B., Rao, P, Pati D. . Role of a Novel Separase Interacting Protein Insep5/Sororin in Sister Chromatid Cohesion and Separation. FASEB Journal. 2007; (21):813-814.
    33. Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D. Hormone-induced chromosomal instability in p53-null mammary epithelium. Cancer Res. 2004 Aug 15; 64(16):5608-16. PMID: 15313898.
      View in: PubMed
    34. Pati D, Zhang N, Plon SE. Linking sister chromatid cohesion and apoptosis: role of Rad21. Mol Cell Biol. 2002 Dec; 22(23):8267-77. PMID: 12417729; PMCID: PMC134054.
    35. Pati D, Habibi HR. . The involvement of protein kinase C and arachidonic acid pathways gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis goldfish ovary. Biology of Reproduction. 2002; (66):813-822.
    36. Eliseeva E, Pati D, Diccinanni MB, Yu AL, Mohsin SK, Margolin JF, Plon SE. Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia. Cell Growth Differ. 2001 Aug; 12(8):427-33. PMID: 11504708.
      View in: PubMed
    37. Pati D, Habibi, HR . Direct action of GnRH variants on goldfish oocyte meiosis and follicular steroidogenesis. Molecular and Cellular Endocrinology. 2000; (160):75-88.
    38. Pati D, Lohka MJ, Habibi HR . Time-related effect of GnRH on histone H1 kinase activity in the goldfish follicle-enclosed oocyte. Canadian Journal of Physiology and Pharmacology. 2000; (78):1067-1071.
    39. Pati D, Meistrich ML, Plon SE. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. Mol Cell Biol. 1999 Jul; 19(7):5001-13. PMID: 10373550; PMCID: PMC84326.
    40. Keramida M, Matsoukas JM, Agelis G, Panagiotopoulos D, Cladas J, Maia HLS, Pati D, Moore GJ, Habibi HR. . Synthesis and activity of tyr(ome)5 - Gonadotropin- releasing hormone (GnRH) analogues with modifications at positions 6, 9 and 10. Letters in Peptide Science. 1998; (5):305-315.
    41. Pati D, Habibi HR. . Presence of salmon GnRH and compounds with GnRH-like activity in the ovary of goldfish. Endocrinology. 1998; (139):2015-2024.
    42. Pati D, Keller C, Groudine M, Plon SE. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol Cell Biol. 1997 Jun; 17(6):3037-46. PMID: 9154802; PMCID: PMC232156.
    43. Nabissi I, Pati D, Polzonetti-Magni A, Habibi HR. . Presence and activity of compounds with GnRH-like activity in the ovary of seabream (Sparus aurata). American Journal of Physiology. 1997; (272):R111-R117.
    44. Deragon KL, Gazourian L, Pati D, Habibi HR, Sower SA. . Characteristics of GnRH binding in the gonads and Effects of lamprey GnRH-I and -III on reproduction in the adult seal lamprey. General and Comparative Endocrinology. 1997; (108):327-339.
    45. Matsoukas JM, Keramida M, Panagiotopoulos D, Mavromoustakos T, Maia HLS, Bigam G, Pati D, Habibi HR, Moore GJ. . 1H-NMR studies of gonadotropin-releasing hormone conformation by nuclear overhauser effect spectroscopy and design of novel GnRH analogue, [Tyr(OMe)5, D-Lys6, Aze9-NHEt]-GnRH: Aromatic ring clustering and receptor binding activity. European Journal of Medicinal Chemistry. 1997; (32):927-940.
    46. Keramida M, Matsoukas JM, Panagiotopoulos D, Maia HLS, Pati D, Habibi HR. . A novel anlog of gonadotropin-releasing hormone containing Tyr(OMe) at positions 5: Synthesis and activity. Letters in Peptide Science. 1996; (3):257-262.
    47. Pati D, Balshaw K, Grinwich D, Hollenberg M, Habibi, HR. . Epidermal growth factor receptor binding and biological activity in goldfish ovary. American Journal of Physiology. 1996; (270):R1065-1072.
    48. Pati D, Habibi HR, Gedamu L. . Inhibition of zinc-induced metallothionein mRNA accumulation by gonadotropin-releasing hormone in human hepatocarcinoma cell line HepG2. European Journal of Biochemistry. 1996; (242):36-40.
    49. Pati D, Habibi HR. . Inhibition of human hepatocarcinoma cell growth by mammalian and fish gonadotropin-releasing hormone. Endocrinology. 1995; (136):75-84.
    50. Habibi HR, Pati D, Ouwens M, Goos HJ Th. . Presence of GnRH binding sites and compounds with GnRH-like activity in the ovary of African catfish, Clarias gariepinus. Biology of Reproduction 1994;50:643-652. 1994; (50):643-652.
    51. Habibi HR, Pati D. . Extrapituitary gonadotropin-releasing hormone (GnRH) binding sites in goldfish. Fish physiology and Biochemistry. 1993; (11):43-49.
    52. Pati D., Habibi HR. . Gonadotropin-releasing hormone (GnRH) binding characteristics in the testis of goldfish (Carassius auratus). Journal of Experimental Zoology. 1993; (267):155-163.
    53. Pati D., Habibi HR. . Characterization of GnRH receptors in the goldfish ovary: variation during follicular development. American Journal of Physiology. 1993; (264):R227-R234.
    54. Habibi H R, Pati D. . “Cellular Communication in Reproduction”, (Facchinetti, F., Henderson, I., Pierantoni, R., Polzonetti Magni, A., editors),. Endocrine and paracrine control of ovarian function: role of compounds with GnRH-like activity in goldfish. In “Cellular Communication in Reproduction”. 1993; 59-70.
    55. Pati D., Habibi, HR. . Characterization of gonadotropin-releasing hormone (GnRH) receptors in the ovary of common carp (Cyprinus carpio). Canadian Journal of Physiology and Pharmacology. 1992; (70):268-274.
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