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JIAN-MING LU

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
AddressOne Baylor Plaza, R431
Houston TX 77030
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    My research is focused on several basic science and translational research projects that are highly relevant to clinical diseases and pancreatic cancer. I have a strong background and research experience in organic chemistry, medicinal and synthetic chemistry, and biochemistry, including enzyme activities and mechanisms.

    In recent years, I have been studying the fields of translational medicine and medicinal chemistry, working with cell-free, well-established in vitro as well as in vivo models. The primary goal of my projects is to develop new, safe, and effective therapies using natural or naturally-derived substances. For example, I have been developing medicines for hyperuricemia-related diseases, such as gout, using natural substances and by modifying their structure to enhance their effects. Currently, I am also screening naturally-derived substances for inhibitors of enzymes such as myeloperoxidase, HIV protease, and arginase, key enzymes in the development of diseases.

    Another focus of my research is the delivery of nanoparticle gene/drug complexes targeted to cancer cells as well as to vascular cells by using antibodies or other specific proteins conjugated to PLGA (poly(lactic-co-glycolic acid)-based nanoparticles. I am developing a new PLGA-based material for molecular imaging and specific drug and gene delivery, which has great potential clinical applications such as molecular diagnostics and targeted therapies.

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    • Cardiovascular disease
    • Drug discovery and development
    • Enzyme inhibitors, mechanisms
    • Gout and hyperuricemia
    • Natural substances and structure modification
    • Organic synthesis, characterization
    • Oxidative stress, free radicals, and antioxidants
    • Pancreatic cancer
    • Polymer nanoparticle drug/gene delivery
    • Xanthine oxidase, HIV protease, cyclooxygenase, arginase


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jamaluddin MS, Liang Z, Lu JM, Yao Q, Chen C. Roles of cardiovascular risk factors in endothelial nitric oxide synthase regulation: an update. Curr Pharm Des. 2014; 20(22):3563-78. PMID: 24180390.
      View in: PubMed
    2. Lü JM, Yao Q, Chen C. 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout. Biochem Pharmacol. 2013 Nov 1; 86(9):1328-37. PMID: 23994369; PMCID: PMC3816736.
    3. Lü JM, Yan S, Jamaluddin S, Weakley SM, Liang Z, Siwak EB, Yao Q, Chen C. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Med Sci Monit. 2012 Aug; 18(8):BR293-298. PMID: 22847190; PMCID: PMC3560711.
    4. Lü JM, Weakley SM, Yang Z, Hu M, Yao Q, Chen C. Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid. Curr Pharm Des. 2012; 18(38):6339-47. PMID: 22974003.
      View in: PubMed
    5. Lü JM, Nurko J, Jiang J, Weakley SM, Lin PH, Yao Q, Chen C. Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries. Med Sci Monit. 2011 Nov; 17(11):BR312-318. PMID: 22037733; PMCID: PMC3275091.
    6. Wu G, Lü JM, van der Donk WA, Kulmacz RJ, Tsai AL. Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects. J Inorg Biochem. 2011 Mar; 105(3):382-90. PMID: 21394223; PMCID: PMC3049311.
    7. Lü JM, Rogge CE, Wu G, Kulmacz RJ, van der Donk WA, Tsai AL. Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping. J Inorg Biochem. 2011 Mar; 105(3):356-65. PMID: 21403766; PMCID: PMC3053578.
    8. Tsai AL, Wu G, Rogge CE, Lü JM, Peng S, van der Donk WA, Palmer G, Gerfen GJ, Kulmacz RJ. Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2. J Inorg Biochem. 2011 Mar; 105(3):366-74. PMID: 21421123; PMCID: PMC3073652.
    9. Lü JM, Nurko J, Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Chen C. Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update. Med Sci Monit. 2010 May; 16(5):RA93-100. PMID: 20424564; PMCID: PMC2927326.
    10. Chen C, Jiang J, Lü JM, Chai H, Wang X, Lin PH, Yao Q. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2010 Jul; 299(1):H193-201. PMID: 20435848; PMCID: PMC2904138.
    11. Lü JM, Lin PH, Yao Q, Chen C. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med. 2010 Apr; 14(4):840-60. PMID: 19754673; PMCID: PMC2927345.
    12. Lü JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol. 2009 Jul; 7(3):293-302. PMID: 19601854; PMCID: PMC2928028.
    13. Lü JM, Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, Chen C. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn. 2009 May; 9(4):325-41. PMID: 19435455; PMCID: PMC2701163.
    14. Lü JM, Rosokha SV, Neretin IS, Kochi JK. Quinones as electron acceptors. X-ray structures, spectral (EPR, UV-vis) characteristics and electron-transfer reactivities of their reduced anion radicals as separated vs contact ion pairs. J Am Chem Soc. 2006 Dec 27; 128(51):16708-19. PMID: 17177421.
      View in: PubMed
    15. Rosokha SV, Lü JM, Newton MD, Kochi JK. Intermolecular electron-transfer mechanisms via quantitative structures and ion-pair equilibria for self-exchange of anionic (dinitrobenzenide) donors. J Am Chem Soc. 2005 May 25; 127(20):7411-20. PMID: 15898790.
      View in: PubMed
    16. Lü JM, Ranjit KT, Rungrojchaipan P, Kevan L. Synthesis of mesoporous aluminophosphate (AlPO) and investigation of zirconium incorporation into mesoporous AlPOs. J Phys Chem B. 2005 May 19; 109(19):9284-93. PMID: 16852110.
      View in: PubMed
    17. Lü JM, Rosokha SV, Lindeman SV, Neretin IS, Kochi JK. "Separated" versus "contact" ion-pair structures in solution from their crystalline states: dynamic effects on dinitrobenzenide as a mixed-valence anion. J Am Chem Soc. 2005 Feb 16; 127(6):1797-809. PMID: 15701015.
      View in: PubMed
    18. Davlieva MG, Lü JM, Lindeman SV, Kochi JK. Crystallographic distinction between "contact" and "separated" ion pairs: structural effects on electronic/ESR spectra of alkali-metal nitrobenzenides. J Am Chem Soc. 2004 Apr 14; 126(14):4557-65. PMID: 15070374.
      View in: PubMed
    19. Lü JM, Rosokha SV, Kochi JK. Stable (long-bonded) dimers via the quantitative self-association of different cationic, anionic, and uncharged pi-radicals: structures, energetics, and optical transitions. J Am Chem Soc. 2003 Oct 8; 125(40):12161-71. PMID: 14519002.
      View in: PubMed
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