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LAISING YEN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressDepartment of Pathology
One Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kannan K, Kordestani GK, Galagoda A, Coarfa C, Yen L. Aberrant MUC1-TRIM46-KRTCAP2 Chimeric RNAs in High-Grade Serous Ovarian Carcinoma. Cancers (Basel). 2015; 7(4):2083-93. PMID: 26492273.
      View in: PubMed
    2. Kannan K, Coarfa C, Chao PW, Luo L, Wang Y, Brinegar AE, Hawkins SM, Milosavljevic A, Matzuk MM, Yen L. Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1272-7. PMID: 25733895; PMCID: PMC4371965.
    3. Kannan K, Coarfa C, Rajapakshe K, Hawkins SM, Matzuk MM, Milosavljevic A, Yen L. CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genet. 2014 Mar; 10(3):e1004216. PMID: 24675677; PMCID: PMC3967933.
    4. Zhang H, Lin W, Kannan K, Luo L, Li J, Chao PW, Wang Y, Chen YP, Gu J, Yen L. Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. Oncotarget. 2013 Nov; 4(11):2135-43. PMID: 24243830; PMCID: PMC3875775.
    5. Wu CC, Kannan K, Lin S, Yen L, Milosavljevic A. Identification of cancer fusion drivers using network fusion centrality. Bioinformatics. 2013 May 1; 29(9):1174-81. PMID: 23505294; PMCID: PMC3634186.
    6. Kannan K, Wang L, Wang J, Ittmann MM, Li W, Yen L. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9172-7. PMID: 21571633; PMCID: PMC3107329.
    7. Wang L, Xi Y, Yu J, Dong L, Yen L, Li W. A statistical method for the detection of alternative splicing using RNA-seq. PLoS One. 2010; 5(1):e8529. PMID: 20072613; PMCID: PMC2798953.
    8. Yen L, Stockwell BR, Mulligan RC. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods Mol Biol. 2009; 540:335-47. PMID: 19381571.
      View in: PubMed
    9. Link KH, Guo L, Ames TD, Yen L, Mulligan RC, Breaker RR. Engineering high-speed allosteric hammerhead ribozymes. Biol Chem. 2007 Aug; 388(8):779-86. PMID: 17655496.
      View in: PubMed
    10. Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006 May; 12(5):797-806. PMID: 16556935; PMCID: PMC1440893.
    11. Yen L, Svendsen J, Lee JS, Gray JT, Magnier M, Baba T, D'Amato RJ, Mulligan RC. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature. 2004 Sep 23; 431(7007):471-6. PMID: 15386015.
      View in: PubMed
    12. Yen L, Gonzalez-Zulueta M, Feldman A, Yuan Y, Fryer H, Dawson T, Dawson V, Kalb RG. Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA. J Neurochem. 2001 Mar; 76(5):1386-94. PMID: 11238723.
      View in: PubMed
    13. Yen L, Strittmatter SM, Kalb RG. Sequence-specific cleavage of Huntingtin mRNA by catalytic DNA. Ann Neurol. 1999 Sep; 46(3):366-73. PMID: 10482267.
      View in: PubMed
    14. Jakowec MW, Yen L, Kalb RG. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience. 1995 Aug; 67(4):909-20. PMID: 7675213.
      View in: PubMed
    15. Yen L, Sibley JT, Constantine-Paton M. Analysis of synaptic distribution within single retinal axonal arbors after chronic NMDA treatment. J Neurosci. 1995 Jun; 15(6):4712-25. PMID: 7540683.
      View in: PubMed
    16. Yen, L. and R.G. Kalb. . Neuroscientist. Recovery from spinal cord injury: New approaches. 1995; 1:321.
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