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overview
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Our goal is to define mechanisms through which early life undernutrition alters metabolism and to determine how undernutrition influences intestinal and liver function. Undernutrition causes acute medical problems, but also long term health problems that may result from permanent epigenetic changes that alter transcription or via changes in the gut microbiome. Current studies focus on how malnutrition alters hepatic secretion, transcriptional programming, gastrointestinal motility, and host-microbiome interactions to impact growth. Our work is pertinent to those suffering from nutritional deficiencies caused by a wide range of medical and socioeconomic factors, including preterm and underweight newborns in the neonatal intensive care unit, children with severe acute malnutrition in the developing world, and adolescents with anorexia nervosa.
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