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WEHRENS, XANDER

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Item Type	Name
Academic Article	Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis.
Academic Article	Infected sternal fracture hematoma after cardiopulmonary resuscitation initially seen as pericarditis.
Academic Article	Usefulness of sinus tachycardia and ST-segment elevation in V(5) to identify impending left ventricular free wall rupture in inferior wall myocardial infarction.
Academic Article	A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty.
Academic Article	Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.
Academic Article	Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.
Academic Article	Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.
Academic Article	Molecular determinants of altered contractility in heart failure.
Academic Article	Cardiac ryanodine receptor function and regulation in heart disease.
Academic Article	Mouse electrocardiography: an interval of thirty years.
Academic Article	Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation.
Academic Article	Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.
Academic Article	Structural determinants of potassium channel blockade and drug-induced arrhythmias.
Academic Article	Subcellular targeting of phosphatases: a novel function of ankyrins.
Academic Article	Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia.
Academic Article	Ryanodine receptors as pharmacological targets for heart disease.
Academic Article	Istaroxime, a novel luso-inotropic agent for the treatment of acute heart failure.
Academic Article	Cardiac rupture.
Academic Article	Novel therapeutic approaches for heart failure by normalizing calcium cycling.
Academic Article	Altered function and regulation of cardiac ryanodine receptors in cardiac disease.
Academic Article	Defective cardiac ryanodine receptor regulation during atrial fibrillation.
Academic Article	Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Academic Article	Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure.
Academic Article	Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data.
Academic Article	Ambulatory ECG recording in mice.
Academic Article	The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.
Academic Article	Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.
Academic Article	Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.
Academic Article	Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction.
Academic Article	Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes.
Academic Article	Worsening renal function is not associated with response to treatment in acute heart failure.
Academic Article	CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban.
Academic Article	Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Academic Article	Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.
Academic Article	Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
Academic Article	The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms?
Academic Article	NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure.
Academic Article	Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.
Academic Article	Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Academic Article	Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
Academic Article	Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.
Academic Article	Transthoracic echocardiography in mice.
Academic Article	Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Academic Article	Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation.
Academic Article	Transverse aortic constriction in mice.
Academic Article	Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Academic Article	Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship.
Academic Article	Emerging role of junctophilin-2 as a regulator of calcium handling in the heart.
Academic Article	CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release.
Academic Article	Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.
Academic Article	Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Academic Article	CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.
Academic Article	Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry?
Academic Article	Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.
Academic Article	Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Academic Article	Role of RyR2 phosphorylation at S2814 during heart failure progression.
Academic Article	Atrial identity is determined by a COUP-TFII regulatory network.
Academic Article	FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.
Academic Article	Myocardial disease in failing hearts: defective excitation-contraction coupling.
Academic Article	Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
Academic Article	Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias.
Academic Article	Diseases associated with altered ryanodine receptor activity.
Academic Article	Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.
Academic Article	Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
Academic Article	Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias.
Academic Article	Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform.
Academic Article	Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome.
Academic Article	Extinguishing intracellular calcium leak: a promising antiarrhythmic approach.
Academic Article	Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.
Concept	Heart
Concept	Heart Conduction System
Concept	Heart Rupture, Post-Infarction
Concept	Heart Atria
Concept	Heart Transplantation
Concept	Heart Ventricles
Concept	Heart Failure
Concept	Heart Defects, Congenital
Concept	Heart Diseases
Concept	Mitochondria, Heart
Concept	Heart Rate
Academic Article	Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.
Academic Article	Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development.
Academic Article	Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.
Academic Article	microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.
Academic Article	Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation.
Academic Article	Alterations in ryanodine receptors and related proteins in heart failure.
Academic Article	Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.
Academic Article	Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.
Academic Article	Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.
Academic Article	Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.
Academic Article	CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.
Academic Article	Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.
Academic Article	Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
Academic Article	Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling.
Academic Article	Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.
Academic Article	Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFa.
Academic Article	The mitochondrial uniporter controls fight or flight heart rate increases.
Academic Article	Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation.
Academic Article	Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling.
Academic Article	Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases.
Academic Article	Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.
Academic Article	It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias.
Academic Article	Protein phosphatase 2A regulatory subunit B56a limits phosphatase activity in the heart.
Academic Article	Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.
Academic Article	The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis.
Academic Article	Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes.
Academic Article	A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock.
Academic Article	Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart.
Academic Article	CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.
Academic Article	SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.
Academic Article	Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome.
Academic Article	Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis.
Academic Article	Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release.
Academic Article	Congenital and drug-induced long-QT syndrome: an update.
Academic Article	Calcium-mediated cellular triggered activity in atrial fibrillation.
Academic Article	Calcium Signaling and Cardiac Arrhythmias.
Academic Article	EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2.
Academic Article	Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.
Academic Article	Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.
Academic Article	Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter?
Academic Article	Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development.
Academic Article	Mouse Models of Cardiac Arrhythmias.
Academic Article	Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors.
Academic Article	In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.
Academic Article	Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation.
Academic Article	Protein Phosphatase 2A Regulates Cardiac Na+ Channels.
Academic Article	Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling.
Academic Article	Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector.
Academic Article	CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias.
Grant	Determining the Role of Junctophilin-2 in Cardiac Disease
Grant	Regulation of Sarcoplasmic Reticulum Calcium Release in Heart Failure
Academic Article	YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In?Vivo.
Academic Article	Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure.
Concept	Isolated Heart Preparation
Academic Article	Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis.
Academic Article	Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.
Academic Article	Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia.
Academic Article	Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure.
Academic Article	Wolff-Parkinson-White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation.
Academic Article	Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies.
Academic Article	Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling.
Academic Article	Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation.
Academic Article	SPEG: a key regulator of cardiac calcium homeostasis.
Academic Article	Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.
Academic Article	Mechanisms underlying pathological Ca2+ handling in diseases of the heart.
Academic Article	Correction to: mechanisms underlying pathological Ca2+ handling in diseases of the heart.
Grant	Junctophilin-2 cleavage in ischemic heart disease
Academic Article	Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart.
Academic Article	Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis.
Academic Article	Atrial-Specific LKB1 Knockdown Represents a Novel Mouse Model of Atrial Cardiomyopathy With Spontaneous Atrial Fibrillation.
Academic Article	Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases.
Academic Article	2022 HRS expert consensus statement on evaluation and management of arrhythmic risk in neuromuscular disorders.
Academic Article	Diagnosing atrial fibrillation: Can we do better than the ECG?
Academic Article	Common disease-promoting signalling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences.
Academic Article	Prolonged ?-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure.
Academic Article	A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice.
Academic Article	Cardiac function, structural, and electrical remodeling by microgravity exposure.
Academic Article	Abnormalities in cardiac and inflammatory biomarkers in ambulatory subjects after COVID-19 infection.
Academic Article	Variant-specific therapy for long QT syndrome type 3.
Academic Article	An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.
Academic Article	PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation.
Academic Article	Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation.
Academic Article	Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
Academic Article	Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice.
Academic Article	Tachycardia and Atrial Fibrillation-Related Cardiomyopathies: Potential Mechanisms and Current Therapies.
Academic Article	In Vivo Cardiac Electrophysiology in Mice: Determination of Atrial and Ventricular Arrhythmic Substrates.
Academic Article	Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies.
Academic Article	AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.
Academic Article	NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy.

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