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LAM, FONG

One or more keywords matched the following properties of LAM, FONG

Property	Value
keywords	Neutrophils, Platelets, Endothelium, Sepsis, Inflammation, Thrombosis, Organ Failure
overview	My clinical and research interests lie in the interactions between neutrophils, platelets, and endothelial cells in the microcirculation. These interactions lead to both the inflammation and thrombosis that occur in patients with inflammatory diseases. I am interested in understanding the mechanisms by which inflammation and thrombosis influence each other in order to develop novel therapies to reduce the morbidity and mortality from pathologic inflammation (such as sepsis, acute lung injury, trauma, and extracorporeal devices). We utilize an array of methodologies, including intravital microscopy to visualize platelet-leukocyte-endothelial interactions in the liver sinusoids of animals in real time. Our laboratory is also collaborating with biomedical engineers at the University of Houston to develop and test novel microfluidic devices in animals. This project is aimed to develop a device that can perform continuous leukapheresis (WBC removal) in a small animal model before performing large animal and, eventually, human trials. The benefits of these novel microfluidic devices is that they may allow for both therapeutic treatment of hyperleukocytosis (occasionally seen in leukemia) as well as for the collection of leukocytes for downstream processing (granulocyte donation, CAR-T cell generation, etc) WITHOUT the need for large catheters or complicated machines. These devices may have particular benefit for infants and small children, as these patients have a relatively small total blood volume compared to the extracorporeal volumes of the currently used systems. This project includes animal anesthesia and surgery, blood collection and testing, and data analysis.

Property

Value

keywords

Neutrophils, Platelets, Endothelium, Sepsis, Inflammation, Thrombosis, Organ Failure

overview

My clinical and research interests lie in the interactions between neutrophils, platelets, and endothelial cells in the microcirculation. These interactions lead to both the inflammation and thrombosis that occur in patients with inflammatory diseases. I am interested in understanding the mechanisms by which inflammation and thrombosis influence each other in order to develop novel therapies to reduce the morbidity and mortality from pathologic inflammation (such as sepsis, acute lung injury, trauma, and extracorporeal devices). We utilize an array of methodologies, including intravital microscopy to visualize platelet-leukocyte-endothelial interactions in the liver sinusoids of animals in real time. Our laboratory is also collaborating with biomedical engineers at the University of Houston to develop and test novel microfluidic devices in animals. This project is aimed to develop a device that can perform continuous leukapheresis (WBC removal) in a small animal model before performing large animal and, eventually, human trials. The benefits of these novel microfluidic devices is that they may allow for both therapeutic treatment of hyperleukocytosis (occasionally seen in leukemia) as well as for the collection of leukocytes for downstream processing (granulocyte donation, CAR-T cell generation, etc) WITHOUT the need for large catheters or complicated machines. These devices may have particular benefit for infants and small children, as these patients have a relatively small total blood volume compared to the extracorporeal volumes of the currently used systems. This project includes animal anesthesia and surgery, blood collection and testing, and data analysis.

One or more keywords matched the following items that are connected to LAM, FONG

Item Type	Name
Concept	Inflammation
Academic Article	Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium.
Grant	UTILIZING SOLUBLE VIMENTIN AND ITS COMPONENTS TO ATTENUATE INFLAMMATION
Academic Article	Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation.
Academic Article	High levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19.
Academic Article	Intravital Microscopy to Study Platelet-Leukocyte-Endothelial Interactions in the Mouse Liver.
Academic Article	A novel interaction between extracellular vimentin and fibrinogen in fibrin formation.

Search Criteria

Inflammation