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PALZKILL, TIMOTHY
One or more keywords matched the following items that are connected to PALZKILL, TIMOTHY
Item TypeName
Academic Article An analysis of why highly similar enzymes evolve differently.
Concept Ceftazidime
Academic Article A triple mutant in the O-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.
Academic Article Structural Basis for Different Substrate Profiles of Two Closely Related Class D ?-Lactamases and Their Inhibition by Halogens.
Academic Article Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability.
Academic Article Characterization of the global stabilizing substitution A77V and its role in the evolution of CTX-M ?-lactamases.
Academic Article The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.
Academic Article Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance.
Grant Beta Lactamase Mutations in Antibiotic Resistance
Academic Article Antagonism between substitutions in ?-lactamase explains a path not taken in the evolution of bacterial drug resistance.
Academic Article Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M ?-lactamase.
Academic Article Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions.
Academic Article Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops.
Academic Article The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate.
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