Header Logo

Search Result Details

Back to Search Results
This page shows the details of why an item matched the keywords from your search.
Search Results
DONEHOWER, LAWRENCE
One or more keywords matched the following items that are connected to DONEHOWER, LAWRENCE
Item TypeName
Academic Article Construction and characterization of molecular clones containing integrated mouse mammary tumor virus sequences.
Academic Article Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.
Academic Article p53 deficiency does not affect the accumulation of point mutations in a transgene target.
Academic Article Transgenic mouse models for tumour-suppressor genes.
Academic Article Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
Academic Article A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice.
Academic Article Gene-targeting and the p53 tumor-suppressor gene.
Academic Article Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients.
Academic Article Androgen suppressed apoptosis is modified in p53 deficient mice.
Academic Article Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss.
Academic Article Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.
Academic Article Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome.
Academic Article Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.
Academic Article p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.
Academic Article Effects of genetic background on tumorigenesis in p53-deficient mice.
Academic Article Astrocytes derived from p53-deficient mice provide a multistep in vitro model for development of malignant gliomas.
Academic Article Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development?
Academic Article Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.
Academic Article Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha.
Academic Article Genomic organization of the mouse double minute 2 gene.
Academic Article The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.
Academic Article Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice.
Academic Article Transgenic animals in toxicology.
Academic Article Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.
Academic Article In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.
Academic Article Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
Academic Article Genetic background alters the spectrum of tumors that develop in p53-deficient mice.
Academic Article The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene.
Academic Article Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation.
Academic Article Effects of p53 mutation on tumor progression: recent insights from mouse tumor models.
Academic Article The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
Academic Article p53 in embryonic development: maintaining a fine balance.
Academic Article Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control.
Academic Article The p53-deficient mouse: a model for basic and applied cancer studies.
Academic Article Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis.
Academic Article Loss of p53 in benzene-induced thymic lymphomas in p53+/- mice: evidence of chromosomal recombination.
Academic Article Effect of intragastric application of N-methylnitrosourea in p53 knockout mice.
Academic Article Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.
Academic Article Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53.
Academic Article Functional analysis of tumor suppressor genes in mice.
Academic Article Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis.
Academic Article Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers.
Academic Article Suppression of thymic lymphomas and increased nonthymic lymphomagenesis in Trp53-deficient mice lacking inducible nitric oxide synthase gene.
Academic Article Reduction in p53 gene dosage diminishes differentiation capacity of osteoblasts.
Academic Article Does p53 affect organismal aging?
Academic Article p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.
Academic Article The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens.
Academic Article Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.
Academic Article Probing p53 biological functions through the use of genetically engineered mouse models.
Academic Article Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.
Academic Article Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines.
Academic Article The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging.
Academic Article Generation and characterization of p53 mutant mice.
Academic Article The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair.
Academic Article Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.
Academic Article Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice.
Academic Article Notch signaling contributes to the pathogenesis of human osteosarcomas.
Academic Article MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.
Academic Article Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.
Academic Article Widespread and tissue specific age-related DNA methylation changes in mice.
Academic Article Insights into aging obtained from p53 mutant mouse models.
Academic Article P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.
Academic Article The utility of genetically altered mouse models for cancer research.
Academic Article Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis.
Academic Article Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor.
Academic Article Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34.
Academic Article Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.
Academic Article DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse.
Academic Article The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Academic Article Altered mammary gland development in the p53+/m mouse, a model of accelerated aging.
Academic Article Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine.
Academic Article Analysis of cellular senescence in culture in vivo: the senescence-associated beta-galactosidase assay.
Academic Article Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer.
Academic Article Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.
Academic Article 20 years studying p53 functions in genetically engineered mice.
Academic Article Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Academic Article Longevity regulation in flies: a role for p53.
Academic Article The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
Academic Article Using mice to examine p53 functions in cancer, aging, and longevity.
Academic Article Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.
Academic Article Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.
Academic Article Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.
Academic Article Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1a proteins at the early and late stages of liver cancer.
Academic Article The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.
Academic Article Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin.
Academic Article Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis.
Academic Article Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.
Academic Article Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.
Academic Article Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
Academic Article Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
Academic Article The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.
Academic Article Genetic instability in animal tumorigenesis models.
Academic Article Murine tumor suppressor models.
Academic Article Mouse models in tumor suppression.
Academic Article Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53.
Academic Article Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model.
Academic Article Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression.
Academic Article Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Academic Article Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Academic Article Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing.
Academic Article p53 mutant mice that display early ageing-associated phenotypes.
Academic Article High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.
Academic Article Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.
Academic Article Diet-gene interactions in p53-deficient mice: insulin-like growth factor-1 as a mechanistic target.
Academic Article Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
Academic Article Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53+/- mice.
Academic Article Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
Academic Article Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.
Academic Article Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.
Academic Article Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.
Concept Mammary Tumor Virus, Mouse
Concept Mice, Inbred CBA
Concept Mice, Knockout
Concept Mice, Inbred NOD
Concept Mice, Inbred BALB C
Concept Mice, Nude
Concept Mice, SCID
Concept Mice, Inbred Strains
Concept Mice
Concept Mice, Mutant Strains
Concept Mice, Inbred ICR
Concept Mice, Inbred C57BL
Concept Mice, Transgenic
Academic Article REG? deficiency promotes premature aging via the casein kinase 1 pathway.
Academic Article Insights into wild-type and mutant p53 functions provided by genetically engineered mice.
Academic Article Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.
Academic Article Notch activation as a driver of osteogenic sarcoma.
Academic Article NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.
Academic Article Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma.
Academic Article Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.
Academic Article Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma.
Academic Article Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.
Academic Article Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential.
Academic Article miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.
Academic Article Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice.
Academic Article PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Grant P53 AND GENOMIC INSTABILITY MODELS
Grant INACTIVATED P53 GENE IN MICE
Grant The effects of Age on Cancer Signaling Pathways in Mice
Grant Biology of Aging Training Grant
Grant P53 and Organismal Aging
Grant ROLE OF VIRUS AND CELL GENES IN RETROVIRUS REPLICATION
Grant Oncogenic Function of a P53-Induced Phosphatase
Grant FURTHER ANALYSIS OF THE P53-DEFICIENT MOUSE
Concept Mice, 129 Strain
Academic Article K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications.
Search Criteria
  • Mice