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One or more keywords matched the following properties of KOSTEN, THOMAS
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overview Following a successful 25 year tenure as professor and chief of Psychiatry at Yale University and VA Connecticut, Dr. Kosten joined the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) in July 2006, bringing over 30 years of exemplary Federal service; the majority of which has been with the Department of Veterans Affairs. Over the period 2006-2011, Dr. Kosten served as the Research Director of the VA national Substance Use Disorders Quality Enhancement Research Initiative (QUERI) program, fully revitalizing a research-to-practice implementation program to provide proven, cutting-edge treatment to improve the lives of veteran populations across the VA health care system. With a joint appointment at Baylor College of Medicine (BCM), Dr. Kosten is the JH Waggoner Chair & Professor of Psychiatry, Pharmacology, Neuroscience and Immunology & Pathology. He is also vice-Chair for Psychiatry and Co-director of the Dan L. Duncan Institute for Clinical and Translational Research (ICTR) at Baylor College of Medicine. His other key appointments are Distinguished Professor of Psychiatry at Peking University Medical School and Professor of Epidemiology and of Behavioral Sciences at MD Anderson Cancer Prevention Center. He established the Division of Addictions Psychiatry at Baylor and Yale and directs their NIH Medications Development Center for substance abuse. A recognized leader in clinical and translational sciences, Dr. Kosten is a recent past recipient of a Research Scientist Award (1987-2010) from the National Institute of Health (NIH), he has served on national and international review groups for medications and vaccines development in substance abuse, and is credited with the development of several cutting-edge discoveries in medications for addictions. A former Congressional Fellow in the House of Representatives, Dr. Kosten has held visiting professorships in Germany, Spain, Greece, China and Canada. He is the founding vice-chair for Added Qualifications in Addiction Psychiatry of the American Board of Psychiatry and Neurology. He is a distinguished fellow in the American Psychiatric Association and fellow of the American College of Neuropsychopharmacology, past president of the American Academy of Addiction Psychiatry, and past president of the College on Problems of Drug Dependence (CPDD). He has received several prestigious awards for clinical research and for his work in vaccine pharmacotherapy for drug addictions, particularly in treating cocaine, methamphetamine, and opiate addictions. He is the current Editor for the American Journal on Addictions, past Editor for the American Journal of Drug and Alcohol Abuse, and serves on the board of several notable journals in substance abuse. Additionally, Dr. Kosten retains ongoing recognition in the Best Doctors in America® ranking, an honor reserved by only 5% of the nation’s doctors. As of 2012, for the 12th year in a row, he has been named by U.S. News & World Report as a Top Doc®, ranking him among the top 10% of psychiatrists in the region, and for the 9th consecutive year, in the top 1% of psychiatrists in the field of Addictions Medicine. He is a much sought-after expert both nationally and internationally in the field of addictions with appearances on National Geographic, Discovery Channel, and PBS as well as print, radio, and online publications that include WIRED, NPR, and the Wall Street Journal, among others. Dr. Kosten’s recent work includes serving on the National Academy of Sciences, Institute of Medicine (IOM) committee on vaccines for substance abuse. He also served on the recently concluded IOM’s Committee on Prevention, Diagnosis, Treatment, and Management of Substance Use Disorders in the U.S. Armed Forces, a congressional mandate via the National Defense Authorization Act for Fiscal Year 2010 (Public Law 111-84), to conduct an independent study on substance use disorders in the military. From his studies in substance dependence, post-traumatic stress disorder, and neuroimaging he has published over 600 papers, books and reviews. His medication contributions include a cocaine vaccine, immunotherapy for hallucinogens, buprenorphine for opioid dependence, disulfiram for cocaine dependence, vasodilators for cocaine induced cerebral perfusion defects, and combining medications with contingency management for opioid and cocaine dependence.
One or more keywords matched the following items that are connected to KOSTEN, THOMAS
Item TypeName
Academic Article A preliminary study of beta endorphin during chronic naltrexone maintenance treatment in ex-opiate addicts.
Academic Article Abuse of cocaine with opioids: psychological aspects of treatment.
Academic Article The antecedents and benefits of achieving abstinence in opioid addicts: a 2.5-year follow-up study.
Academic Article Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers.
Academic Article Cocaine abuse among opioid addicts: demographic and diagnostic factors in treatment.
Academic Article Multidimensionality and prediction of treatment outcome in opioid addicts: 2.5-year follow-up.
Academic Article A preliminary study of desipramine in the treatment of cocaine abuse in methadone maintenance patients.
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Academic Article A single-blind investigation of four auricular needle puncture configurations.
Academic Article Family denial as a prognostic factor in opiate addict treatment outcome.
Academic Article Effects of ethnicity on low-dose opiate stabilization.
Academic Article Tryptophan depletion and attenuation of cue-induced craving for cocaine.
Academic Article Reduction of opiate withdrawal-like symptoms by cocaine abuse during methadone and buprenorphine maintenance.
Academic Article Effects of sham and real auricular needling: implications for trials of acupuncture for cocaine addiction.
Academic Article Acupuncture for the treatment of cocaine addiction. Investigation of a needle puncture control.
Academic Article Buprenorphine versus methadone maintenance for opioid dependence.
Academic Article Three methods of opioid detoxification in a primary care setting. A randomized trial.
Academic Article Prognostic factors in Buprenorphine- versus methadone-maintained patients.
Academic Article Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics.
Academic Article Changes concurrent with initiation of abstinence from cocaine abuse.
Academic Article Chronic disulfiram treatment effects on intranasal cocaine administration: initial results.
Academic Article Gender differences in cocaine use and treatment response.
Academic Article Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine.
Academic Article Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients.
Academic Article A randomized controlled trial of auricular acupuncture for cocaine dependence.
Academic Article Treatment of heroin (diamorphine) addiction: current approaches and future prospects.
Academic Article Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients.
Academic Article Use of drug combinations in treatment of opioid withdrawal.
Academic Article Benzodiazepine use in posttraumatic stress disorder among veterans with substance abuse.
Academic Article Treatment of early AIDS dementia in intravenous drug users: high versus low dose peptide T.
Academic Article A preliminary investigation of lamotrigine for cocaine abuse in HIV-seropositive patients.
Academic Article Current concepts in pharmacotherapy of substance abuse.
Academic Article A comprehensive pharmacologic-psychosocial treatment program for HIV-seropositive cocaine- and opioid-dependent patients. Preliminary findings.
Academic Article Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone.
Academic Article A randomized trial of buprenorphine maintenance for heroin dependence in a primary care clinic for substance users versus a methadone clinic.
Academic Article Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans.
Academic Article Contingency management interventions: from research to practice.
Academic Article Neuroleptic use in the treatment of Post-Traumatic Stress Disorder.
Academic Article Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency management.
Academic Article A placebo controlled trial of bupropion for smoking cessation in schizophrenia.
Academic Article Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia.
Academic Article Office-based treatment for opioid dependence: reaching new patient populations.
Academic Article Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients.
Academic Article Human therapeutic cocaine vaccine: safety and immunogenicity.
Academic Article The potential of dopamine agonists in drug addiction.
Academic Article Mazindol treatment of cocaine abuse. A double-blind investigation.
Academic Article Utility of crossover designs in clinical trials: efficacy of desipramine vs. placebo in opioid-dependent cocaine abusers.
Academic Article Therapeutic vaccines for substance dependence.
Academic Article Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients.
Academic Article Therapeutic vaccines for substance dependence.
Academic Article Management of drug and alcohol withdrawal.
Academic Article Pharmacotherapeutic environments for substance use disorders.
Academic Article Human laboratory and neuroimaging studies in substance use disorders: developing new treatment approaches.
Academic Article Choosing a behavioral therapy platform for pharmacotherapy of substance users.
Academic Article Preliminary study of buprenorphine and bupropion for opioid-dependent smokers.
Academic Article Novel approaches to the treatment of cocaine addiction.
Academic Article Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response.
Academic Article Opioid dependence treatment: options in pharmacotherapy.
Academic Article Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics.
Academic Article Vaccine pharmacotherapy for the treatment of cocaine dependence.
Academic Article Buprenorphine for office-based practice: consensus conference overview.
Academic Article Challenges in increasing access to buprenorphine treatment for opiate addiction.
Academic Article Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics.
Academic Article Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population.
Academic Article Pharmacological blocking agents for treating substance abuse.
Academic Article Pharmacotherapy improves treatment outcome in depressed cocaine addicts.
Academic Article Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms.
Academic Article Client issues in drug abuse treatment: addressing multiple drug abuse.
Academic Article Novel pharmacotherapeutic treatments for cocaine addiction.
Academic Article Immunotherapy for the treatment of drug abuse.
Academic Article Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings.
Academic Article Short-term tropisetron treatment and cognitive and P50 auditory gating deficits in schizophrenia.
Academic Article Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics.
Academic Article Cocaine withdrawal symptoms predict medication response in cocaine users.
Academic Article Progesterone effects on cocaine use in male cocaine users maintained on methadone: a randomized, double-blind, pilot study.
Academic Article Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction.
Academic Article Treatment outcome predictors for cocaine dependence.
Academic Article Treatment of patients with substance use disorders, second edition. American Psychiatric Association.
Academic Article Pharmacotherapy for addictions: partnering with contingency management.
Academic Article Association of spirituality and sobriety during a behavioral spirituality intervention for Twelve Step (TS) recovery.
Academic Article Therapeutic options and challenges for substances of abuse.
Academic Article Pharmacogenetic treatments for drug addiction: alcohol and opiates.
Academic Article Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics.
Academic Article Aripiprazole treatment of risperidone-induced hyperprolactinemia.
Academic Article Stereotactic neurosurgical treatment of drug addiction.
Academic Article Depressive symptoms during buprenorphine treatment of opioid abusers.
Academic Article Antidepressants in the treatment of PTSD.
Academic Article Improving PTSD/substance abuse treatment in the VA: a survey of providers.
Academic Article Prescription pain medication dependence.
Academic Article Active immunotherapy for the Treatment of Cocaine Dependence.
Academic Article Noradrenergic a1 receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial.
Academic Article Opioid detoxification and naltrexone induction strategies: recommendations for clinical practice.
Academic Article The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial.
Academic Article The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency.
Academic Article Buprenorphine treatment of cocaine abuse.
Academic Article Pharmacotherapeutic interventions for cocaine abuse. Matching patients to treatments.
Academic Article Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.
Academic Article DBH gene as predictor of response in a cocaine vaccine clinical trial.
Academic Article Naloxone challenge as a biological predictor of treatment outcome in opiate addicts.
Academic Article Treatment of severe lithium-induced polyuria with amiloride.
Academic Article The effect of multiple family therapy on addict family functioning: a pilot study.
Academic Article A 2.5 year follow-up of treatment retention and reentry among opioid addicts.
Academic Article A 2.5-year follow-up of cocaine use among treated opioid addicts. Have our treatments helped?
Academic Article Cortisol levels during chronic naltrexone maintenance treatment in ex-opiate addicts.
Academic Article Strategies to improve compliance with narcotic antagonists.
Academic Article Complementary marital roles of male heroin addicts: evolution and intervention tactics.
Academic Article Cue-elicited cocaine craving and autogenic relaxation. Association with treatment outcome.
Academic Article Mazindol treatment for cocaine dependence.
Academic Article Mazindol for relapse prevention to cocaine abuse in methadone-maintained patients.
Academic Article A multicenter trial of bupropion for cocaine dependence in methadone-maintained patients.
Academic Article Desipramine, amantadine, or fluoxetine in buprenorphine-maintained cocaine users.
Academic Article Pemoline for the treatment of cocaine dependence in methadone-maintained patients.
Academic Article Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse.
Academic Article Baclofen-assisted detoxification from opiates. A pilot study.
Academic Article Treatment of dual diagnosis patients: a relapse prevention group approach.
Academic Article When is less treatment better? The role of social anxiety in matching methadone patients to psychosocial treatments.
Academic Article Neurobiological adaptations to psychostimulants and opiates as a basis of treatment development.
Academic Article Improving treatment outcome in pregnant opiate-dependent women.
Academic Article Cannabinoid antagonists: a treatment in search of an illness.
Academic Article Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence.
Academic Article Effects of progesterone treatment on cocaine responses in male and female cocaine users.
Academic Article Consensus statement on office-based treatment of opioid dependence using buprenorphine.
Academic Article Depression as a prognostic factor for pharmacological treatment of cocaine dependence.
Academic Article Methadone versus buprenorphine with contingency management or performance feedback for cocaine and opioid dependence.
Academic Article Treatment of heroin addicts using buprenorphine.
Academic Article Effects of topiramate in combination with intravenous nicotine in overnight abstinent smokers.
Academic Article Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients.
Academic Article New hot topics sections: 1. China's new march forward in addiction treatment: methadone for the masses. 2. Issues in formulating DSM V.
Academic Article The neurobiology of opioid dependence: implications for treatment.
Academic Article Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics.
Academic Article Traditional medicine in the treatment of drug addiction.
Academic Article Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine.
Academic Article Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.
Academic Article Efficacy of opiate maintenance therapy and adjunctive interventions for opioid dependence with comorbid cocaine use disorders: A systematic review and meta-analysis of controlled clinical trials.
Academic Article Opioid antagonist challenges in buprenorphine maintained patients.
Academic Article Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba.
Academic Article Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine ?-hydroxylase.
Academic Article Gender differences in socio-demographic and clinical characteristics of methamphetamine inpatients in a Chinese population.
Academic Article Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse.
Academic Article ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse.
Academic Article Inpatient vs. outpatient cocaine abuse treatments.
Concept Substance Abuse Treatment Centers
Concept Relaxation Therapy
Concept Drug Therapy, Combination
Concept Acupuncture Therapy
Concept Combined Modality Therapy
Concept Complementary Therapies
Concept Treatment Outcome
Concept Drug Therapy
Concept Behavior Therapy
Concept Family Therapy
Academic Article Naltrexone with or without guanfacine for preventing relapse to opiate addiction in St.-Petersburg, Russia.
Academic Article The ?-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial.
Academic Article Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment.
Academic Article Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms.
Academic Article Epidemiological trends and the advances of treatments of amphetamine-type stimulants (ATS) in China.
Academic Article Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial.
Academic Article The influence of dopamine ?-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study.
Academic Article Buprenorphine in the treatment of opioid addiction: opportunities, challenges and strategies.
Academic Article Emerging drugs for the treatment of cocaine use disorder: a review of neurobiological targets and pharmacotherapy.
Academic Article A conjugate vaccine attenuates morphine- and heroin-induced behavior in rats.
Academic Article Withdrawal Symptoms and Nicotine Dependence Severity Predict Virtual Reality Craving in Cigarette-Deprived Smokers.
Academic Article Reinforcement sensitivity underlying treatment-seeking smokers' affect, smoking reinforcement motives, and affective responses.
Academic Article Pharmacologic management of comorbid post-traumatic stress disorder and addictions.
Academic Article Update on pharmacotherapy for treatment of opioid use disorder.
Academic Article Vaccines in the Treatment of Substance Abuse.
Academic Article Pharmacogenetics of Dopamine ?-Hydroxylase in cocaine dependence therapy with doxazosin.
Academic Article Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials.
Academic Article Exenatide once weekly for smoking cessation: study protocol for a randomized clinical trial.
Academic Article Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies.
Academic Article Minocycline adjunctive treatment to risperidone for negative symptoms in schizophrenia: Association with pro-inflammatory cytokine levels.
Academic Article Buprenorphine for the treatment of posttraumatic stress disorder.
Academic Article Review article: Effective management of opioid withdrawal symptoms: A gateway to opioid dependence treatment.
Academic Article Preclinical efficacy of an anti-methamphetamine vaccine using E6020 adjuvant.
Grant REDUCING HIV RISK IN METHADONE-MAINTAINED PATIENTS
Grant Cocaine Vaccine for Methadone Maintained Patients
Grant CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
Grant 11TH - 15TH ANNUAL MEETINGS AND SYMPOSIA
Grant Heroin Addiction Treatment: Naltrexone and Lofexidine
Grant Pharmacotherapy for opioid and cocaine dependence
Grant THERAPEUTIC COCAINE VACCINE
Grant Comorbidity in Cocaine and Opioid Pharmacotherapy
Grant REDUCING AIDS RISKS
Grant Multisite Controlled Trial of Cocaine Vaccine (1of 6) Lead Site/ Houston Treatmen
Grant 9TH/13TH ANNUAL MEETING AND SYMPOSIUM
Grant Human methamphetamine vaccine: Translational Avante Garde Award
Grant YALE MEDICATIONS DEVELOPMENT RESEARCH CENTER
Grant PHARMACOTHERAPY OF IV COCAINE USE IN METHADONE PATIENTS
Academic Article Cigarette smoking, type 2 diabetes mellitus, and glucagon-like peptide-1 receptor agonists as a potential treatment for smokers with diabetes: An integrative review.
Concept Opiate Substitution Treatment
Concept Molecular Targeted Therapy
Concept Virtual Reality Exposure Therapy
Academic Article Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction.
Academic Article The effect of minocycline on amelioration of cognitive deficits and pro-inflammatory cytokines levels in patients with schizophrenia.
Academic Article Lofexidine in Combination With Oral Naltrexone for Opioid Use Disorder Relapse Prevention: A Pilot Randomized, Double-Blind, Placebo-Controlled Study.
Academic Article Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant.
Academic Article The relationship between subjective effects induced by a single dose of ketamine and treatment response in patients with major depressive disorder: A systematic review.
Academic Article One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia.
Grant Complementary Combination Therapy for Cocaine Dependence
Academic Article The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.
Academic Article Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions.
Academic Article Comorbid alcohol use and post-traumatic stress disorders: Pharmacotherapy with aldehyde dehydrogenase 2 inhibitors versus current agents.
Academic Article Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.
Academic Article Rationale, design and methods of VA-BRAVE: a randomized comparative effectiveness trial of two formulations of buprenorphine for treatment of opioid use disorder in veterans.
Academic Article Low-Dose Ziprasidone in Combination with Sertraline for First-Episode Drug-Na?ve Patients with Schizophrenia: a Randomized Controlled Trial.
Academic Article Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder: A Review.
Academic Article Exenatide as an adjunct to nicotine patch for smoking cessation and prevention of postcessation weight gain among treatment-seeking smokers with pre-diabetes and/or overweight: study protocol for a randomised, placebo-controlled clinical trial.
Academic Article Comorbid alcohol use disorder and posttraumatic stress disorder: A proof-of-concept randomized placebo-controlled trial of buprenorphine and naltrexone combination treatment.
Academic Article A double-blind, randomized controlled study of the effects of celecoxib on clinical symptoms and cognitive impairment in patients with drug-na?ve first episode schizophrenia: pharmacogenetic impact of cyclooxygenase-2 functional polymorphisms.
Academic Article Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis.
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