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DE GROOT, JOHN FREDERICK

One or more keywords matched the following items that are connected to DE GROOT, JOHN FREDERICK

Item Type	Name
Academic Article	A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma.
Academic Article	Decreasing radiation therapy utilization in adult patients with glioblastoma multiforme: a population-based analysis.
Academic Article	Modulating antiangiogenic resistance by inhibiting the signal transducer and activator of transcription 3 pathway in glioblastoma.
Academic Article	Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study.
Concept	Glioblastoma
Academic Article	Survival outcome of early versus delayed bevacizumab treatment in patients with recurrent glioblastoma.
Academic Article	Leptomeningeal dissemination in glioblastoma; an inspection of risk factors, treatment, and outcomes at a single institution.
Academic Article	Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma.
Academic Article	Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma.
Academic Article	The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo.
Academic Article	Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Academic Article	Phase II trial of irinotecan and thalidomide in adults with recurrent glioblastoma multiforme.
Academic Article	Dapsone induced methemoglobinemia in a patient with glioblastoma.
Academic Article	Improving the prognosis for patients with glioblastoma: the rationale for targeting Src.
Academic Article	Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept.
Academic Article	Phase I trial of verubulin (MPC-6827) plus carboplatin in patients with relapsed glioblastoma multiforme.
Academic Article	Cytokines associated with toxicity in the treatment of recurrent glioblastoma with aflibercept.
Academic Article	Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition.
Academic Article	Neutrophils promote the malignant glioma phenotype through S100A4.
Academic Article	Resistance to antiangiogenic therapy.
Academic Article	Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice.
Academic Article	Moving toward molecular classification of diffuse gliomas in adults.
Academic Article	Isotretinoin maintenance therapy for glioblastoma: a retrospective review.
Academic Article	Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma.
Academic Article	Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Academic Article	Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype.
Academic Article	Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy.
Academic Article	Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies.
Academic Article	High-dose antiangiogenic therapy for glioblastoma: less may be more?
Academic Article	Antiangiogenic therapy for glioblastoma: the challenge of translating response rate into efficacy.
Academic Article	Molecular subtypes of glioblastoma are relevant to lower grade glioma.
Academic Article	Pregnancy and glial brain tumors.
Academic Article	Brain Malignancy Steering Committee clinical trials planning workshop: report from the Targeted Therapies Working Group.
Academic Article	Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma.
Academic Article	Antiangiogenic therapy for glioblastoma: current status and future prospects.
Academic Article	Toward precision medicine in glioblastoma: the promise and the challenges.
Academic Article	Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy.
Academic Article	VEGF Manipulation in Glioblastoma.
Academic Article	A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study.
Academic Article	ReACT Phase II trial: a critical evaluation of the use of rindopepimut plus bevacizumab to treat EGFRvIII-positive recurrent glioblastoma.
Academic Article	Impact of IDH1 mutation status on outcome in clinical trials for recurrent glioblastoma
Academic Article	Prioritization schema for immunotherapy clinical trials in glioblastoma
Academic Article	Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models
Academic Article	Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma
Academic Article	VEGF manipulation in glioblastoma
Academic Article	Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma
Academic Article	Demonstration of DCE-MRI as an early pharmacodynamic biomarker of response to VEGF Trap in glioblastoma
Academic Article	A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma
Academic Article	A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma
Academic Article	Molecular subtypes of glioblastoma are relevant to lower grade glioma
Academic Article	Toward precision medicine in glioblastoma
Academic Article	Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma.
Academic Article	Effect of health disparities on overall survival of patients with glioblastoma.
Academic Article	Disparities along the glioblastoma clinical trials landscape.
Academic Article	Highlighting the need for reliable clinical trials in glioblastoma.
Academic Article	Impact of IDH1 mutation status on outcome in clinical trials for recurrent glioblastoma.
Academic Article	High-grade gliomas.
Academic Article	Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models.
Academic Article	Demonstration of DCE-MRI as an early pharmacodynamic biomarker of response to VEGF Trap in glioblastoma.
Academic Article	Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma.
Academic Article	A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma.
Academic Article	Prioritization schema for immunotherapy clinical trials in glioblastoma.
Academic Article	Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy.
Academic Article	Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials.
Academic Article	Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy.
Academic Article	Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma.
Academic Article	Rapid identification and validation of novel targeted approaches for Glioblastoma: A combined ex vivo-in vivo pharmaco-omic model.
Academic Article	Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients with prior antiangiogenic therapy.
Academic Article	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.
Academic Article	A relative increase in circulating platelets following chemoradiation predicts for poor survival of patients with glioblastoma.
Academic Article	Treatment of Glioblastoma.
Academic Article	Multi-center study finds postoperative residual non-enhancing component of glioblastoma as a new determinant of patient outcome.
Academic Article	Targeting intercellular adhesion molecule-1 prolongs survival in mice bearing bevacizumab-resistant glioblastoma.
Academic Article	Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma.
Academic Article	Validation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma.
Academic Article	A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models.
Academic Article	Treatment of Glioblastoma in the Elderly.
Academic Article	Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas.
Academic Article	Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma.
Academic Article	Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.
Academic Article	Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
Academic Article	Prospective Clinical Sequencing of Adult Glioma.
Academic Article	Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.
Academic Article	Clinical trial participation of patients with glioblastoma at The University of Texas MD Anderson Cancer Center.
Academic Article	Challenges and strategies for successful clinical development of immune checkpoint inhibitors in glioblastoma.
Academic Article	Treatment strategies for glioblastoma in older patients: age is just a number.
Academic Article	Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages.
Academic Article	Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo.
Academic Article	A randomized controlled phase III study of VB-111 combined with bevacizumab vs bevacizumab monotherapy in patients with recurrent glioblastoma (GLOBE).
Academic Article	EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.
Academic Article	Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.
Academic Article	Impact of adverse events of bevacizumab on survival outcomes of patients with recurrent glioblastoma.
Academic Article	Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial.
Academic Article	Immunotherapy for Neuro-Oncology.
Academic Article	Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in intact biological specimens.
Academic Article	Proton therapy reduces the likelihood of high-grade radiation-induced lymphopenia in glioblastoma patients: phase II randomized study of protons vs photons.
Academic Article	Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.
Academic Article	Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma.
Academic Article	A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram.
Academic Article	PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma.
Academic Article	A prospective phase II randomized trial of proton radiotherapy vs intensity-modulated radiotherapy for patients with newly diagnosed glioblastoma.
Academic Article	The promise of DNA damage response inhibitors for the treatment of glioblastoma.
Academic Article	Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Academic Article	Validation of diffusion MRI as a biomarker for efficacy using randomized phase III trial of bevacizumab with or without VB-111 in recurrent glioblastoma.
Academic Article	Results of a phase I trial to assess the safety of macitentan in combination with temozolomide for the treatment of recurrent glioblastoma.
Academic Article	Isocitrate Dehydrogenase Wild-type Glial Tumors, Including Glioblastoma.
Academic Article	Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells.
Academic Article	Immunotherapy for Neuro-oncology.
Academic Article	Clinical and survival characteristics of primary and secondary gliosarcoma patients.
Academic Article	Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma.
Academic Article	Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival.
Academic Article	External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma.
Academic Article	The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma.
Academic Article	Correcting the drug development paradigm for glioblastoma requires serial tissue sampling.
Academic Article	"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
Academic Article	Neuronal differentiation drives the antitumor activity of mitogen-activated protein kinase kinase (MEK) inhibition in glioblastoma.
Academic Article	Repeated blood-brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial.
Academic Article	Strategies to Improve Drug Delivery Across the Blood-Brain Barrier for Glioblastoma.

Search Criteria

Glioblastoma