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BEDFORD, MARK T

One or more keywords matched the following items that are connected to BEDFORD, MARK T

Item Type	Name
Concept	Arginine
Concept	Protein-Arginine N-Methyltransferases
Academic Article	Crosstalk between Arg?1175 methylation and Tyr?1173 phosphorylation negatively modulates EGFR-mediated ERK activation.
Academic Article	The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.
Academic Article	Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.
Academic Article	Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice.
Academic Article	Small molecule regulators of protein arginine methyltransferases.
Academic Article	Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development.
Academic Article	Techniques in protein methylation.
Academic Article	Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3).
Academic Article	Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression.
Academic Article	Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression.
Academic Article	Arginine methylation an emerging regulator of protein function.
Academic Article	PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family.
Academic Article	Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo.
Academic Article	The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6.
Academic Article	Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.
Academic Article	The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.
Academic Article	Protein methylation and DNA repair.
Academic Article	Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice.
Academic Article	Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.
Academic Article	Arginine methylation at a glance.
Academic Article	Arginine methylation of the histone H3 tail impedes effector binding.
Academic Article	CARM1 promotes adipocyte differentiation by coactivating PPARgamma.
Academic Article	Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.
Academic Article	Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1.
Academic Article	Protein arginine methylation in mammals: who, what, and why.
Academic Article	Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.
Academic Article	Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family.
Academic Article	Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification.
Academic Article	Enzymatic activity is required for the in vivo functions of CARM1.
Academic Article	Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).
Academic Article	CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Academic Article	Histone arginine methylation.
Academic Article	TDRD3 is an effector molecule for arginine-methylated histone marks.
Academic Article	Xenoestrogens regulate the activity of arginine methyltransferases.
Academic Article	Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation.
Academic Article	Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.
Academic Article	Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.
Academic Article	Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2.
Academic Article	Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity.
Academic Article	Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.
Academic Article	Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.
Academic Article	Methods applied to the study of protein arginine methylation.
Academic Article	Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.
Academic Article	Protein arginine methyltransferases and cancer.
Academic Article	Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.
Academic Article	Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs.
Academic Article	A TR-FRET-based functional assay for screening activators of CARM1.
Academic Article	Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.
Academic Article	Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Academic Article	Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.
Academic Article	Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.
Academic Article	Readers of histone methylarginine marks.
Academic Article	A gain-of-function mouse model identifies PRMT6 as a NF-?B coactivator.
Academic Article	PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.
Academic Article	Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus.
Academic Article	The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation.
Academic Article	Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.
Academic Article	PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch.
Academic Article	Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly.
Academic Article	2 The family of protein arginine metkyltransferases
Academic Article	Coactivator-associated arginine methyltransferase-1 function in alveolar epithelial senescence and elastase-induced emphysema susceptibility
Academic Article	Arginine demethylation of G3BP1 promotes stress granule assembly
Academic Article	Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs
Academic Article	Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions
Academic Article	Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation
Academic Article	Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility.
Academic Article	Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs.
Academic Article	PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.
Academic Article	PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud.
Academic Article	The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.
Academic Article	The arginine methyltransferase CARM1 represses p300?ACT?CREMt activity and is required for spermiogenesis.
Academic Article	Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.
Academic Article	PRMT1 loss sensitizes cells to PRMT5 inhibition.
Concept	Protein-Arginine Deiminases
Academic Article	CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.
Academic Article	PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages.
Academic Article	Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity.
Academic Article	CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
Academic Article	PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation.
Academic Article	Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.
Academic Article	Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6.
Academic Article	CARM1 regulates replication fork speed and stress response by stimulating PARP1.
Academic Article	Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens.
Academic Article	Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases.
Academic Article	Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses.
Academic Article	Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Academic Article	The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer.
Academic Article	CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth.
Academic Article	Effectors and effects of arginine methylation.
Academic Article	CARM1 arginine methyltransferase as a therapeutic target for cancer.
Academic Article	PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition.

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Arginine