| Item Type | Name |
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Academic Article
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Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
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Academic Article
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The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.
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Academic Article
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Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
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Academic Article
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Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.
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Concept
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Tumor Cells, Cultured
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Academic Article
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HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
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Academic Article
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Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
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Academic Article
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Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.
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Academic Article
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Human hematopoietic cell express two forms of the cytokine receptor common gamma-chain (gamma c).
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Academic Article
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Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.
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Academic Article
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Growth suppression of human ovarian cancer cell lines by the introduction of a p16 gene via a recombinant adenovirus.
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Academic Article
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XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells.
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Academic Article
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Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells.
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Academic Article
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Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.
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Academic Article
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Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer.
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Academic Article
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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
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Academic Article
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The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
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Academic Article
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Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress.
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Academic Article
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Expression of ras oncogene leads to down-regulation of protein kinase C.
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Academic Article
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Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells.
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Academic Article
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Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
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Academic Article
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A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action.
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Academic Article
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CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
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Academic Article
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Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro.
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Academic Article
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The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.
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Academic Article
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Expression of p16 induces transcriptional downregulation of the RB gene.
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Academic Article
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Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
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Academic Article
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PIK3CA is implicated as an oncogene in ovarian cancer.
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Academic Article
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Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
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Academic Article
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The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression.
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Academic Article
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Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer.
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Academic Article
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In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).
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Academic Article
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Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
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Academic Article
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A gonadotropin-releasing hormone-responsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells.
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Academic Article
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Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
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Academic Article
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Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.
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Academic Article
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Genetic analysis of early- versus late-stage ovarian tumors.
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Academic Article
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Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.
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Academic Article
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Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers.
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Academic Article
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Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
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Academic Article
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Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
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Academic Article
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Overexpression of kallikrein 10 in epithelial ovarian carcinomas.
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Academic Article
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Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
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Academic Article
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Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.
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Academic Article
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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
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Academic Article
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Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.
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Academic Article
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Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells.
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Academic Article
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Activation of the Na+/H+ antiport is not required for epidermal growth factor-dependent gene expression, growth inhibition or proliferation in human breast cancer cells.
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Academic Article
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Lysophospholipids activate ovarian and breast cancer cells.
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Academic Article
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Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites.
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Academic Article
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Role of aberrant sialylation of chronic myeloid leukemia granulocytes on binding and signal transduction by chemotactic peptides and colony stimulating factors.
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Academic Article
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Cell cycle dependent regulation of the protein kinase TTK.
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Academic Article
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Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.
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Academic Article
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The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.
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Academic Article
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Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status.
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Academic Article
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Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.
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Academic Article
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Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
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Academic Article
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In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
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Academic Article
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Human telomerase reverse transcriptase promoter regulation in normal and malignant human ovarian epithelial cells.
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Academic Article
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Future for ovarian cancer screening: novel markers from emerging technologies of transcriptional profiling and proteomics.
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Academic Article
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Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
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Academic Article
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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
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Academic Article
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Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.
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Academic Article
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Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.
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Academic Article
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The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
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Academic Article
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Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.
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Academic Article
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Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
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Academic Article
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Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.
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Academic Article
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Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.
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Academic Article
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Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells.
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Academic Article
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End stage renal disease serum contains a specific renal cell growth factor.
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Academic Article
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CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C.
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Academic Article
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Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
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Academic Article
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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
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Academic Article
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Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms.
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Academic Article
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Differential signaling by an anti-p185(HER2) antibody and heregulin.
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Academic Article
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Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.
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Academic Article
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Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity.
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Academic Article
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Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
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Academic Article
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Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine.
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Academic Article
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DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
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Academic Article
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The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin.
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Academic Article
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Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase.
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Academic Article
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MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
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Academic Article
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Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines.
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Academic Article
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hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.
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Academic Article
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Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition.
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Academic Article
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Inferring causal molecular networks: empirical assessment through a community-based effort.
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Academic Article
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An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors.
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Academic Article
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Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.
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Academic Article
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RCP induces Slug expression and cancer cell invasion by stabilizing ?1 integrin.
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Academic Article
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Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
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Academic Article
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Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p.
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Academic Article
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RNA editing derived epitopes function as cancer antigens to elicit immune responses.
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Academic Article
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Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery.
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Academic Article
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Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity.
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Academic Article
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MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors.
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Academic Article
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Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance.
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Academic Article
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Interleukin enhancer-binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma.
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