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ALLISON, JAMES P

One or more keywords matched the following items that are connected to ALLISON, JAMES P

Item Type	Name
Concept	Interleukin-17
Academic Article	Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice.
Academic Article	Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer.
Academic Article	Restoring function in exhausted CD8 T cells during chronic viral infection.
Academic Article	Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function.
Academic Article	SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
Academic Article	CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.
Academic Article	Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors.
Academic Article	Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance.
Academic Article	CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases.
Academic Article	Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.
Academic Article	Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.
Academic Article	Immune modulation in cancer with antibodies.
Academic Article	Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer.
Academic Article	CTLA-4: new insights into its biological function and use in tumor immunotherapy.
Academic Article	B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].
Academic Article	MHC class II-independent and -dependent T cell expansion and B cell hyperactivity in vivo in mice deficient in CD152 (CTLA-4).
Academic Article	Checkpoint blockade in cancer immunotherapy.
Academic Article	CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells.
Academic Article	The B7 family and cancer therapy: costimulation and coinhibition.
Academic Article	Local secretion of anti-CTLA-4 enhances the therapeutic efficacy of a cancer immunotherapy with reduced evidence of systemic autoimmunity.
Academic Article	Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Academic Article	Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.
Academic Article	Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.
Academic Article	Response to "Ipilimumab (Yervoy) and the TGN1412 catastrophe".
Academic Article	Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy.
Academic Article	Co-stimulation in T cell responses.
Academic Article	The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor.
Academic Article	BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Academic Article	Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma.
Academic Article	CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems.
Academic Article	Principles and use of anti-CTLA4 antibody in human cancer immunotherapy.
Academic Article	CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism.
Academic Article	A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer.
Academic Article	Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells.
Academic Article	Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections.
Academic Article	Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
Academic Article	PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
Academic Article	Inhibitors of B7-CD28 costimulation in urologic malignancies.
Academic Article	Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.
Academic Article	Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
Academic Article	Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. The journal of experimental medicine. 1995. 182: 459-465.
Academic Article	Cutting edge: CTLA-4 on effector T cells inhibits in trans.
Academic Article	Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.
Academic Article	Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Academic Article	Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
Academic Article	Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.
Academic Article	B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
Academic Article	Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer.
Academic Article	Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.
Academic Article	Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy.
Academic Article	Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model.
Academic Article	CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.
Academic Article	Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial.
Academic Article	Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients.
Academic Article	Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.
Academic Article	Cytotoxic T lymphocyte antigen-4 blockade enhances antitumor immunity by stimulating melanoma-specific T-cell motility.
Academic Article	Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.
Academic Article	Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness.
Academic Article	Erratum: anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.
Academic Article	The future of immune checkpoint therapy.
Academic Article	Strategies for combining immunotherapy with radiation for anticancer therapy.
Academic Article	Immune Checkpoint Blockade in Cancer Therapy: The 2015 Lasker-DeBakey Clinical Medical Research Award.
Academic Article	Anticancer immunotherapy by CTLA-4 blockade
Academic Article	CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
Academic Article	Induction of CNS inflammatory disease as a consequence of CTLA-4/B7 blockade
Academic Article	Loss of IFN-Î³ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
Academic Article	Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
Academic Article	Anticancer immunotherapy by CTLA-4 blockade
Academic Article	Blockade of CTLA-4 combined with a GM-CSF vaccine cures mice from the highly tumorigenic, poorly immunogenic melanoma B16-BL6, and induces skin depigmentation
Academic Article	Lack of regulation by CTLA-4 in the autoimmune NOD mouse
Academic Article	Interdependent IL-7 and IFN-Î³ signalling in T-cell controls tumour eradication by combined Î±-CTLA-4+Î±-PD-1 therapy
Academic Article	CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection.
Academic Article	Checkpoints.
Academic Article	A conversation with James Allison.
Academic Article	Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.
Academic Article	Interdependent IL-7 and IFN-? signalling in T-cell controls tumour eradication by combined a-CTLA-4+a-PD-1 therapy.
Academic Article	Loss of IFN-? Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.
Academic Article	Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Academic Article	Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.
Academic Article	Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.
Academic Article	Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade.
Academic Article	Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.
Academic Article	Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy.
Academic Article	Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers.
Academic Article	Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study.
Academic Article	Fundamental Mechanisms of Immune Checkpoint Blockade Therapy.
Academic Article	Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
Academic Article	Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Academic Article	TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.
Concept	CTLA-4 Antigen
Academic Article	Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers-Response.
Academic Article	Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.
Academic Article	Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies.
Academic Article	Dissecting the mechanisms of immune checkpoint therapy.
Academic Article	Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma.
Academic Article	Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer.
Academic Article	Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade.
Academic Article	Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-na?ve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment.
Academic Article	Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma.
Academic Article	Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration.
Academic Article	T cells specific for a-myosin drive immunotherapy-related myocarditis.
Academic Article	The future of targeting cytotoxic T-lymphocyte-associated protein-4: Is there a role?
Academic Article	ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype.

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Interleukin 17