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Ran Cheng

TitlePostdoc Fellows and Associates
InstitutionBaylor College of Medicine
DepartmentPostDoc
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cheng R, Lin H, Yu X, Misra S, Mitchell AD, Woyach JA, Qi X, Wang J. Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders. bioRxiv. 2026 Feb 15. PMID: 41727153; PMCID: PMC12918932.
      Citations:    
    2. Shu G, Lang M, Deng J, Zhang Y, Cheng R, Pan J, Wang X, Liu D, Zhang C, Chen X, Sun SK. An Ultralong-Circulating Tantalum-Based Computed Tomography Contrast Agent for Vascular Imaging in Large Animals. ACS Nano. 2026 Jan 13; 20(1):507-521. PMID: 41408730.
      Citations:    Fields:    Translation:HumansAnimals
    3. Lu D, Yu X, Lin H, Cheng R, Yang B, Zhang M, Chen J, Li F, Qi X, Wang J. Design, Optimization, and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties. J Med Chem. 2025 Nov 13; 68(21):22246-22263. PMID: 41134612; PMCID: PMC12681228.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Lin H, Yu X, Cheng R, Qi X, Yang YY, Zhou S, Che X, Wang J. Beyond the G-Loop: CRBN Molecular Glues Potently Target VAV1 via a Novel SH3 RT-Loop Degron. bioRxiv. 2025 Jun 09. PMID: 40661494; PMCID: PMC12258994.
      Citations:    
    5. Wang X, Guo S, Chen J, Cheng R, Zhou F, Huang L, Yang L, Lu Z, Li S, Li C, Mao W, Tian R, Xu P. Integrated network pharmacology and molecular docking combined with metabolomics to identify the pharmacological mechanisms of Jiedu Huoxue decoction against cisplatin-induced acute kidney injury. J Ethnopharmacol. 2025 Jul 24; 351:120088. PMID: 40482862.
      Citations:    Fields:    Translation:AnimalsCells
    6. Boutelle AM, Mabene AR, Yao D, Xu H, Wang M, Tang YJ, Lopez SS, Sinha S, Demeter J, Cheng R, Benard BA, McCrea EM, Valente LJ, Drainas AP, Fischer M, Majeti R, Petrov DA, Jackson PK, Yang F, Winslow MM, Bassik MC, Attardi LD. Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network. Cell Death Differ. 2025 Nov; 32(11):1954-1969. PMID: 40263541; PMCID: PMC12572384.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Cheng R, Zhu Y, Yang LQ, Xiao L, Fang XH, Zhang Q. Dysregulated serum levels of kisspeptin, NKB, GABA in women with polycystic ovary syndrome and their association with hormonal profiles. Gynecol Endocrinol. 2025 Dec; 41(1):2463533. PMID: 39932739.
      Citations: 1     Fields:    Translation:Humans
    8. Boutelle AM, Mabene AR, Yao D, Xu H, Wang M, Tang YJ, Lopez SS, Sinha S, Demeter J, Cheng R, Benard BA, Valente LJ, Drainas AP, Fischer M, Majeti R, Petrov DA, Jackson PK, Yang F, Winslow MM, Bassik MC, Attardi LD. Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network. bioRxiv. 2024 Sep 18. PMID: 39345444; PMCID: PMC11429870.
      Citations:    
    9. Lin H, Riching K, Lai MP, Lu D, Cheng R, Qi X, Wang J. Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools for Monitoring Targeted Protein Degradation. ACS Med Chem Lett. 2024 Aug 08; 15(8):1367-1375. PMID: 39140070; PMCID: PMC11318018.
      Citations: 9     
    10. Xiao YX, Lee SY, Aguilera-Uribe M, Samson R, Au A, Khanna Y, Liu Z, Cheng R, Aulakh K, Wei J, Farias AG, Reilly T, Birkadze S, Habsid A, Brown KR, Chan K, Mero P, Huang JQ, Billmann M, Rahman M, Myers C, Andrews BJ, Youn JY, Yip CM, Rotin D, Derry WB, Forman-Kay JD, Moses AM, Priti?anac I, Gingras AC, Moffat J. The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation. Cell Rep. 2024 07 23; 43(7):114417. PMID: 38980795.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Cheng R, Tian RM, Huang LH, Wang XW, Guo S, Wu AJ, Li C, Chen J, Li SJ, Chen M, Mao W, Xu P. [Effect and mechanism of Jiedu Huoxue Decoction in regulating YAP/ACSL4 pathway to inhibit ferroptosis in treatment of acute kidney injury]. Zhongguo Zhong Yao Za Zhi. 2024 Jan; 49(1):151-161. PMID: 38403348.
      Citations:    
    12. Dahal S, Clayton K, Cabral T, Cheng R, Jahanshahi S, Ahmed C, Koirala A, Villasmil Ocando A, Malty R, Been T, Hernandez J, Mangos M, Shen D, Babu M, Calarco J, Chabot B, Attisano L, Houry WA, Cochrane A. On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine. J Virol. 2023 10 31; 97(10):e0039623. PMID: 37706687; PMCID: PMC10617549.
      Citations:    
    13. Wu CT, Lidsky PV, Xiao Y, Cheng R, Lee IT, Nakayama T, Jiang S, He W, Demeter J, Knight MG, Turn RE, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Nayak JV, Milla C, Andino R, Jackson PK. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Cell. 2023 01 05; 186(1):112-130.e20. PMID: 36580912; PMCID: PMC9715480.
      Citations:    
    14. Lu D, Yu X, Lin H, Cheng R, Monroy EY, Qi X, Wang MC, Wang J. Applications of covalent chemistry in targeted protein degradation. Chem Soc Rev. 2022 Nov 14; 51(22):9243-9261. PMID: 36285735; PMCID: PMC9669245.
      Citations: 5     Fields:    Translation:Cells
    15. Yu X, Guo WH, Lin H, Cheng R, Monroy EY, Jin F, Ding L, Lu D, Qi X, Wang MC, Wang J. Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development. Curr Res Chem Biol. 2022; 2. PMID: 36712232; PMCID: PMC9879287.
      Citations:    
    16. Cheng R, Fujinaga M, Yang J, Rong J, Haider A, Ogasawara D, Van RS, Shao T, Chen Z, Zhang X, Calderon Leon ER, Zhang Y, Mori W, Kumata K, Yamasaki T, Xie L, Sun S, Wang L, Ran C, Shao Y, Cravatt B, Josephson L, Zhang MR, Liang SH. A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network. Acta Pharmacol Sin. 2022 Nov; 43(11):3002-3010. PMID: 35513432; PMCID: PMC9622914.
      Citations:    
    17. Chen CK, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L, Snyder MP, Weissman JS, Segal E, Jackson PK, Chang HY. Structured elements drive extensive circular RNA translation. Mol Cell. 2021 10 21; 81(20):4300-4318.e13. PMID: 34437836; PMCID: PMC8567535.
      Citations:    
    18. Chaikovsky AC, Li C, Jeng EE, Loebell S, Lee MC, Murray CW, Cheng R, Demeter J, Swaney DL, Chen SH, Newton BW, Johnson JR, Drainas AP, Shue YT, Seoane JA, Srinivasan P, He A, Yoshida A, Hipkins SQ, McCrea E, Poltorack CD, Krogan NJ, Diehl JA, Kong C, Jackson PK, Curtis C, Petrov DA, Bassik MC, Winslow MM, Sage J. The AMBRA1 E3 ligase adaptor regulates the stability of cyclin?D. Nature. 2021 04; 592(7856):794-798. PMID: 33854239; PMCID: PMC8246597.
      Citations:    
    19. Wong RW, Balachandran A, Cheung PK, Cheng R, Pan Q, Stoilov P, Harrigan PR, Blencowe BJ, Branch DR, Cochrane A. An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing. PLoS Pathog. 2020 02; 16(2):e1008307. PMID: 32069328; PMCID: PMC7048317.
      Citations:    
    20. Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. J Med Chem. 2019 04 11; 62(7):3336-3353. PMID: 30829483; PMCID: PMC6581563.
      Citations:    
    21. Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K. ?-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress. Biochim Biophys Acta Gen Subj. 2018 10; 1862(10):2271-2280. PMID: 30031111.
      Citations:    
    22. Cheng R, Mori W, Ma L, Alhouayek M, Hatori A, Zhang Y, Ogasawara D, Yuan G, Chen Z, Zhang X, Shi H, Yamasaki T, Xie L, Kumata K, Fujinaga M, Nagai Y, Minamimoto T, Svensson M, Wang L, Du Y, Ondrechen MJ, Vasdev N, Cravatt BF, Fowler C, Zhang MR, Liang SH. In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies. J Med Chem. 2018 03 22; 61(6):2278-2291. PMID: 29481079; PMCID: PMC5966020.
      Citations:    
    23. Zhang X, Kumata K, Yamasaki T, Cheng R, Hatori A, Ma L, Zhang Y, Xie L, Wang L, Kang HJ, Sheffler DJ, Cosford NDP, Zhang MR, Liang SH. Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2. ACS Chem Neurosci. 2017 09 20; 8(9):1937-1948. PMID: 28565908; PMCID: PMC5607115.
      Citations:    
    24. Wang L, Cheng R, Fujinaga M, Yang J, Zhang Y, Hatori A, Kumata K, Yang J, Vasdev N, Du Y, Ran C, Zhang MR, Liang SH. A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation. J Med Chem. 2017 06 22; 60(12):5222-5227. PMID: 28530834; PMCID: PMC5576052.
      Citations:    
    25. Lin H, Ha K, Lu G, Fang X, Cheng R, Zuo Q, Zhang P. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Mol Cell Biol. 2015 Nov; 35(21):3657-68. PMID: 26283732; PMCID: PMC4589603.
      Citations: 15     Fields:    Translation:AnimalsCells
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