"Apolipoprotein L1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS .
| Descriptor ID |
D000075944
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| MeSH Number(s) |
D10.532.091.750.500 D12.776.070.400.750.500 D12.776.521.120.750.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoprotein L1".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein L1".
This graph shows the total number of publications written about "Apolipoprotein L1" by people in this website by year, and whether "Apolipoprotein L1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoprotein L1" by people in Profiles.
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The role of HLA antigens in recurrent primary focal segmental glomerulosclerosis. Front Immunol. 2023; 14:1124249.
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APOL1 Kidney Risk Variants and Proteomics. Clin J Am Soc Nephrol. 2022 05; 17(5):684-692.
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The key role of NLRP3 and STING in APOL1-associated podocytopathy. J Clin Invest. 2021 10 15; 131(20).
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Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers. PLoS One. 2019; 14(9):e0221957.
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APOL1 Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis. J Am Soc Nephrol. 2019 10; 30(10):2027-2036.
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Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia. PLoS One. 2016; 11(10):e0164364.
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Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease. Pediatr Nephrol. 2015 Jun; 30(6):983-9.
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APOL1 variants associate with increased risk of CKD among African Americans. J Am Soc Nephrol. 2013 Sep; 24(9):1484-91.
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Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int. 2013 Jan; 83(1):114-20.
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APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. J Am Soc Nephrol. 2011 Nov; 22(11):1991-6.