XANDER WEHRENS to Male
This is a "connection" page, showing publications XANDER WEHRENS has written about Male.
Connection Strength
0.866
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Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility. Am J Physiol Heart Circ Physiol. 2025 Nov 01; 329(5):H1055-H1071.
Score: 0.039
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Atrial fibroblast-derived macrophage migration inhibitory factor promotes atrial macrophage accumulation in postoperative atrial fibrillation. JCI Insight. 2025 Sep 23; 10(18).
Score: 0.039
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Macrophage-mediated IL-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation. J Clin Invest. 2025 May 01; 135(9).
Score: 0.037
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Structure-activity optimization of ryanodine receptor modulators for the treatment of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2025 Jul; 22(7):e192-e204.
Score: 0.036
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Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement. Clin Sci (Lond). 2024 Sep 18; 138(18):1173-1177.
Score: 0.036
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Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling. J Gen Physiol. 2020 11 02; 152(11).
Score: 0.028
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Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling. Basic Res Cardiol. 2020 06 26; 115(4):49.
Score: 0.027
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Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 06 20; 4(12).
Score: 0.025
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Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262.
Score: 0.024
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Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Circulation. 2018 10 09; 138(15):1569-1581.
Score: 0.024
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Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. J Mol Cell Cardiol. 2018 01; 114:1-9.
Score: 0.022
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SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017 Jan 06; 120(1):110-119.
Score: 0.021
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Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol. 2016 Dec 15; 225:371-380.
Score: 0.021
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Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505.
Score: 0.019
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It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5.
Score: 0.019
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Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 01; 103(1):178-87.
Score: 0.018
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Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655.
Score: 0.016
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Alternative splicing: a key mechanism for ankyrin-B functional diversity? J Mol Cell Cardiol. 2008 Dec; 45(6):709-11.
Score: 0.012
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Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17.
Score: 0.011
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ATP1A3 Variants, Variably Penetrant Short QT Intervals, and Lethal Ventricular Arrhythmias. JAMA Pediatr. 2025 May 01; 179(5):529-539.
Score: 0.009
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Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome. Circ Genom Precis Med. 2024 Aug; 17(4):e004614.
Score: 0.009
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Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. J Mol Cell Cardiol. 2024 Sep; 194:85-95.
Score: 0.009
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Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024 Jun 10; 9(11).
Score: 0.009
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AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022.
Score: 0.009
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Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-Ib?C-X mice with persistent atrial fibrillation. J Mol Cell Cardiol. 2024 05; 190:1-12.
Score: 0.009
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Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circ Heart Fail. 2023 12; 16(12):e010351.
Score: 0.009
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FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 2003 Jun 27; 113(7):829-40.
Score: 0.008
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Cardiac rupture. N Engl J Med. 2003 May 29; 348(22):2264.
Score: 0.008
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Novel insights in the congenital long QT syndrome. Ann Intern Med. 2002 Dec 17; 137(12):981-92.
Score: 0.008
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Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation. Br J Surg. 2002 Feb; 89(2):185-91.
Score: 0.008
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Usefulness of sinus tachycardia and ST-segment elevation in V(5) to identify impending left ventricular free wall rupture in inferior wall myocardial infarction. Am J Cardiol. 2001 Aug 15; 88(4):414-7.
Score: 0.007
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Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021; 17(11):2871-2883.
Score: 0.007
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TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death. Am J Med Genet A. 2021 03; 185(3):923-929.
Score: 0.007
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Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. Nature. 2020 11; 587(7834):460-465.
Score: 0.007
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Use of an intact mouse skeletal muscle preparation for endocrine vascular studies: evaluation of the model. Horm Metab Res. 2000 Sep; 32(9):378-80.
Score: 0.007
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Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation. Circ Res. 2020 09 25; 127(8):1036-1055.
Score: 0.007
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Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation. Circulation. 2020 09 22; 142(12):1159-1172.
Score: 0.007
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Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy. Cardiovasc Res. 2020 05 01; 116(6):1199-1213.
Score: 0.007
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Wolff-Parkinson-White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation. Am J Med Genet A. 2020 06; 182(6):1387-1399.
Score: 0.007
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Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 03 04; 10(1):4043.
Score: 0.007
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A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Am Heart J. 2000 Mar; 139(3):430-6.
Score: 0.007
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Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 03; 17(3):503-511.
Score: 0.006
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Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071.
Score: 0.006
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Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 03 01; 115(3):556-569.
Score: 0.006
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Protein Phosphatase 2A Regulates Cardiac Na+ Channels. Circ Res. 2019 03; 124(5):737-746.
Score: 0.006
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Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling. J Cell Physiol. 2019 07; 234(7):11587-11601.
Score: 0.006
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CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. J Am Heart Assoc. 2018 10 02; 7(19):e010393.
Score: 0.006
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Circadian Variation of Ventricular Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia. JACC Clin Electrophysiol. 2017 11; 3(11):1308-1317.
Score: 0.006
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Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017 06 15; 595(12):4089-4108.
Score: 0.005
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SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644.
Score: 0.005
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Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis. Hum Mol Genet. 2016 11 15; 25(22):4983-4995.
Score: 0.005
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Infected sternal fracture hematoma after cardiopulmonary resuscitation initially seen as pericarditis. Am Heart J. 1996 Sep; 132(3):685-6.
Score: 0.005
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Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903.
Score: 0.005
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Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H713-24.
Score: 0.005
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Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016 08 12; 291(33):17247-57.
Score: 0.005
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Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol. 2016 06 01; 594(11):3005-30.
Score: 0.005
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Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1105-12.
Score: 0.005
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PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71.
Score: 0.005
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CaMKIId mediates ?-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ?-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91.
Score: 0.005
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Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. Dis Model Mech. 2015 Apr; 8(4):363-71.
Score: 0.005
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Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015 Apr 01; 184:190-197.
Score: 0.005
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The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20; 6:6081.
Score: 0.005
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Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFa. Nat Commun. 2015 Jan 19; 6:6018.
Score: 0.005
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Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res. 2015 Jan 02; 116(1):e1-e10.
Score: 0.005
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Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic Res Cardiol. 2014; 109(6):447.
Score: 0.005
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TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process. Hypertension. 2014 Dec; 64(6):1260-5.
Score: 0.005
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CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83.
Score: 0.004
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Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014 Apr 29; 129(17):1742-50.
Score: 0.004
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Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285.
Score: 0.004
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Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14; 129(2):145-156.
Score: 0.004
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Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 01; 101(1):165-74.
Score: 0.004
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Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57.
Score: 0.004
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Worsening renal function is not associated with response to treatment in acute heart failure. Int J Cardiol. 2013 Sep 01; 167(5):1912-7.
Score: 0.004
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Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 05; 125(22):2751-61.
Score: 0.004
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Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83.
Score: 0.004
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Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70.
Score: 0.004
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Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol. 2012 Mar 13; 59(11):998-1005.
Score: 0.004
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Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22; 483(7387):96-9.
Score: 0.004
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Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med. 2011 Dec 14; 3(113):113ra125.
Score: 0.004
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Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22.
Score: 0.004
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Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J Mol Cell Cardiol. 2011 Dec; 51(6):936-44.
Score: 0.004
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Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship. Am Heart J. 2011 Mar; 161(3):567-73.
Score: 0.004
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Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data. Int J Cardiol. 2011 Aug 04; 150(3):264-9.
Score: 0.003
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PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest. 2009 Dec; 119(12):3797-806.
Score: 0.003
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Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 2009 Apr; 106(4):1280-92.
Score: 0.003
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20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet. 2009 Mar; 46(3):168-75.
Score: 0.003
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Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12179-84.
Score: 0.003
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Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20; 107(19):2459-66.
Score: 0.002
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Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovasc Res. 2002 Sep; 55(4):768-77.
Score: 0.002
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Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin. J Invest Dermatol. 2002 Feb; 118(2):323-6.
Score: 0.002
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Microcirculatory effects of experimental acute limb ischaemia-reperfusion. Br J Surg. 2001 Jun; 88(6):816-24.
Score: 0.002
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Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel. Circ Res. 2001 Apr 13; 88(7):740-5.
Score: 0.002
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Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. Cell Struct Funct. 1997 Feb; 22(1):65-72.
Score: 0.001