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XANDER WEHRENS to Ryanodine Receptor Calcium Release Channel

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This is a "connection" page, showing publications XANDER WEHRENS has written about Ryanodine Receptor Calcium Release Channel.
XANDER WEHRENS
Connection Strength
17.694
Ryanodine Receptor Calcium Release Channel
  1. Macrophage-mediated IL-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation. J Clin Invest. 2025 May 01; 135(9).
    View in: PubMed
    Score: 0.772
  2. Structure-activity optimization of ryanodine receptor modulators for the treatment of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2025 Jul; 22(7):e192-e204.
    View in: PubMed
    Score: 0.750
  3. Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity. Circ Arrhythm Electrophysiol. 2023 02; 16(2):e010858.
    View in: PubMed
    Score: 0.667
  4. Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases. Expert Opin Ther Targets. 2022 04; 26(4):303-317.
    View in: PubMed
    Score: 0.633
  5. Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure. Expert Opin Ther Targets. 2020 01; 24(1):25-36.
    View in: PubMed
    Score: 0.539
  6. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 Sep 28; 123(8):953-963.
    View in: PubMed
    Score: 0.494
  7. Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs. Int J Cardiol. 2017 Jan 15; 227:668-673.
    View in: PubMed
    Score: 0.433
  8. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol. 2016 Dec 15; 225:371-380.
    View in: PubMed
    Score: 0.431
  9. Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):177-84.
    View in: PubMed
    Score: 0.404
  10. Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice. Int J Cardiol. 2014 Oct 20; 176(3):994-1000.
    View in: PubMed
    Score: 0.373
  11. Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 01; 103(1):178-87.
    View in: PubMed
    Score: 0.364
  12. Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res. 2014 Apr 11; 114(8):1311-9; discussion 1319.
    View in: PubMed
    Score: 0.363
  13. Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta. 2013 Dec; 1832(12):2425-31.
    View in: PubMed
    Score: 0.342
  14. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655.
    View in: PubMed
    Score: 0.336
  15. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr; 10(4):592-9.
    View in: PubMed
    Score: 0.331
  16. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 03; 110(3):465-70.
    View in: PubMed
    Score: 0.308
  17. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun; 32(6):749-57.
    View in: PubMed
    Score: 0.297
  18. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 08; 123(9):979-88.
    View in: PubMed
    Score: 0.292
  19. Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias. Trends Cardiovasc Med. 2011 Feb; 21(2):48-51.
    View in: PubMed
    Score: 0.291
  20. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79.
    View in: PubMed
    Score: 0.286
  21. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 01; 89(4):734-43.
    View in: PubMed
    Score: 0.285
  22. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb; 8(2):323-5.
    View in: PubMed
    Score: 0.284
  23. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70.
    View in: PubMed
    Score: 0.279
  24. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8.
    View in: PubMed
    Score: 0.272
  25. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54.
    View in: PubMed
    Score: 0.239
  26. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17.
    View in: PubMed
    Score: 0.227
  27. Ryanodine receptors as pharmacological targets for heart disease. Acta Pharmacol Sin. 2007 Jul; 28(7):937-44.
    View in: PubMed
    Score: 0.227
  28. Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias. Eur Heart J. 2007 May; 28(9):1054-6.
    View in: PubMed
    Score: 0.224
  29. The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms? Heart Rhythm. 2007 Jun; 4(6):794-7.
    View in: PubMed
    Score: 0.218
  30. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):511-8.
    View in: PubMed
    Score: 0.205
  31. Intellectual and Neurodevelopmental Delays in Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: Distinct Characteristics and a More Malignant Neurocardiac Phenotype. Circ Arrhythm Electrophysiol. 2025 Oct; 18(10):e013437.
    View in: PubMed
    Score: 0.201
  32. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9607-12.
    View in: PubMed
    Score: 0.197
  33. Ryanodine receptor-targeted anti-arrhythmic therapy. Ann N Y Acad Sci. 2005 Jun; 1047:366-75.
    View in: PubMed
    Score: 0.196
  34. Genetics, manifestations, and management of catecholaminergic polymorphic ventricular tachycardia. Curr Opin Cardiol. 2025 May 01; 40(3):150-157.
    View in: PubMed
    Score: 0.191
  35. Intracellular calcium release and cardiac disease. Annu Rev Physiol. 2005; 67:69-98.
    View in: PubMed
    Score: 0.191
  36. Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations. Mayo Clin Proc. 2004 Nov; 79(11):1367-71.
    View in: PubMed
    Score: 0.188
  37. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73.
    View in: PubMed
    Score: 0.184
  38. Ca2+/calmodulin-dependent kinase IIdC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak. ESC Heart Fail. 2024 Aug; 11(4):2191-2199.
    View in: PubMed
    Score: 0.181
  39. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004 Apr 09; 304(5668):292-6.
    View in: PubMed
    Score: 0.181
  40. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 Apr 02; 94(6):e61-70.
    View in: PubMed
    Score: 0.180
  41. Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers. J Gen Physiol. 2024 Apr 01; 156(4).
    View in: PubMed
    Score: 0.180
  42. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci. 2003 Dec; 28(12):671-8.
    View in: PubMed
    Score: 0.177
  43. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 2003 Jun 27; 113(7):829-40.
    View in: PubMed
    Score: 0.172
  44. Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice. Cardiovasc Res. 2022 10 21; 118(13):2805-2818.
    View in: PubMed
    Score: 0.164
  45. Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia. Arch Toxicol. 2023 01; 97(1):73-92.
    View in: PubMed
    Score: 0.163
  46. Prolonged ?-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure. Elife. 2022 08 01; 11.
    View in: PubMed
    Score: 0.161
  47. Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling. J Gen Physiol. 2020 11 02; 152(11).
    View in: PubMed
    Score: 0.143
  48. Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation. Circulation. 2020 09 22; 142(12):1159-1172.
    View in: PubMed
    Score: 0.140
  49. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 06 20; 4(12).
    View in: PubMed
    Score: 0.130
  50. Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter? Cardiovasc Res. 2018 09 01; 114(11):1428-1429.
    View in: PubMed
    Score: 0.123
  51. EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586.
    View in: PubMed
    Score: 0.117
  52. Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. J Mol Cell Cardiol. 2018 01; 114:1-9.
    View in: PubMed
    Score: 0.116
  53. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993.
    View in: PubMed
    Score: 0.113
  54. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 06 15; 595(12):4001-4008.
    View in: PubMed
    Score: 0.111
  55. Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci. 2016 12 01; 129(23):4388-4398.
    View in: PubMed
    Score: 0.108
  56. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903.
    View in: PubMed
    Score: 0.106
  57. Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H713-24.
    View in: PubMed
    Score: 0.106
  58. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72.
    View in: PubMed
    Score: 0.105
  59. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol. 2016 06 01; 594(11):3005-30.
    View in: PubMed
    Score: 0.103
  60. A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003180.
    View in: PubMed
    Score: 0.103
  61. CaMKIId mediates ?-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ?-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91.
    View in: PubMed
    Score: 0.098
  62. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22.
    View in: PubMed
    Score: 0.094
  63. Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. Am J Physiol Heart Circ Physiol. 2014 Nov 01; 307(9):H1317-26.
    View in: PubMed
    Score: 0.093
  64. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83.
    View in: PubMed
    Score: 0.092
  65. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285.
    View in: PubMed
    Score: 0.089
  66. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 01; 101(1):165-74.
    View in: PubMed
    Score: 0.088
  67. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83.
    View in: PubMed
    Score: 0.079
  68. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70.
    View in: PubMed
    Score: 0.079
  69. Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys J. 2012 03 07; 102(5):L19-21.
    View in: PubMed
    Score: 0.078
  70. Stress synchronizes calcium release and promotes SR calcium leak. J Physiol. 2010 Feb 01; 588(Pt 3):391-2.
    View in: PubMed
    Score: 0.068
  71. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4.
    View in: PubMed
    Score: 0.067
  72. Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):677-85.
    View in: PubMed
    Score: 0.067
  73. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 2009 Apr; 106(4):1280-92.
    View in: PubMed
    Score: 0.063
  74. Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem Soc Trans. 2007 Nov; 35(Pt 5):952-6.
    View in: PubMed
    Score: 0.058
  75. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007 Oct; 22:342-50.
    View in: PubMed
    Score: 0.058
  76. Diseases associated with altered ryanodine receptor activity. Subcell Biochem. 2007; 45:273-321.
    View in: PubMed
    Score: 0.055
  77. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12179-84.
    View in: PubMed
    Score: 0.053
  78. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7906-10.
    View in: PubMed
    Score: 0.052
  79. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3456-61.
    View in: PubMed
    Score: 0.052
  80. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35.
    View in: PubMed
    Score: 0.050
  81. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 2005 Jun 28; 111(25):3342-6.
    View in: PubMed
    Score: 0.049
  82. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32.
    View in: PubMed
    Score: 0.049
  83. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1267-79.
    View in: PubMed
    Score: 0.047
  84. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation. 2004 Jun 29; 109(25):3208-14.
    View in: PubMed
    Score: 0.046
  85. Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci. 2004 May; 1015:144-59.
    View in: PubMed
    Score: 0.046
  86. Molecular determinants of altered contractility in heart failure. Ann Med. 2004; 36 Suppl 1:70-80.
    View in: PubMed
    Score: 0.044
  87. Myocardial disease in failing hearts: defective excitation-contraction coupling. Cold Spring Harb Symp Quant Biol. 2002; 67:533-41.
    View in: PubMed
    Score: 0.039
  88. Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation. Circ Res. 2020 09 25; 127(8):1036-1055.
    View in: PubMed
    Score: 0.035
  89. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 08 20; 140(8):681-693.
    View in: PubMed
    Score: 0.032
  90. Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 03 01; 115(3):556-569.
    View in: PubMed
    Score: 0.032
  91. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93.
    View in: PubMed
    Score: 0.026
  92. Protein phosphatase 2A regulatory subunit B56a limits phosphatase activity in the heart. Sci Signal. 2015 Jul 21; 8(386):ra72.
    View in: PubMed
    Score: 0.025
  93. Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophys J. 2014 Dec 16; 107(12):2815-2827.
    View in: PubMed
    Score: 0.024
  94. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14; 129(2):145-156.
    View in: PubMed
    Score: 0.022
  95. Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57.
    View in: PubMed
    Score: 0.022
  96. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51.
    View in: PubMed
    Score: 0.016
  97. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20; 107(19):2459-66.
    View in: PubMed
    Score: 0.011
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Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.