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Connection

XANDER WEHRENS to Heart Failure

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This is a "connection" page, showing publications XANDER WEHRENS has written about Heart Failure.
XANDER WEHRENS
Connection Strength
4.763
Heart Failure
  1. Tachycardia and Atrial Fibrillation-Related Cardiomyopathies: Potential Mechanisms and Current Therapies. JACC Heart Fail. 2024 Apr; 12(4):605-615.
    View in: PubMed
    Score: 0.332
  2. Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling. Basic Res Cardiol. 2020 06 26; 115(4):49.
    View in: PubMed
    Score: 0.260
  3. Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure. Expert Opin Ther Targets. 2020 01; 24(1):25-36.
    View in: PubMed
    Score: 0.251
  4. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 06 20; 4(12).
    View in: PubMed
    Score: 0.242
  5. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Circulation. 2018 10 09; 138(15):1569-1581.
    View in: PubMed
    Score: 0.231
  6. Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter? Cardiovasc Res. 2018 09 01; 114(11):1428-1429.
    View in: PubMed
    Score: 0.229
  7. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017 Jan 06; 120(1):110-119.
    View in: PubMed
    Score: 0.201
  8. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol. 2016 Dec 15; 225:371-380.
    View in: PubMed
    Score: 0.201
  9. Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res. 2014 Apr 11; 114(8):1311-9; discussion 1319.
    View in: PubMed
    Score: 0.169
  10. Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta. 2013 Dec; 1832(12):2425-31.
    View in: PubMed
    Score: 0.160
  11. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79.
    View in: PubMed
    Score: 0.133
  12. Transverse aortic constriction in mice. J Vis Exp. 2010 Apr 21; (38).
    View in: PubMed
    Score: 0.128
  13. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8.
    View in: PubMed
    Score: 0.127
  14. Istaroxime, a novel luso-inotropic agent for the treatment of acute heart failure. Curr Opin Investig Drugs. 2007 Sep; 8(9):769-77.
    View in: PubMed
    Score: 0.107
  15. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17.
    View in: PubMed
    Score: 0.106
  16. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):511-8.
    View in: PubMed
    Score: 0.095
  17. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9607-12.
    View in: PubMed
    Score: 0.092
  18. Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. J Mol Cell Cardiol. 2024 Sep; 194:85-95.
    View in: PubMed
    Score: 0.086
  19. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73.
    View in: PubMed
    Score: 0.086
  20. Ca2+/calmodulin-dependent kinase IIdC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak. ESC Heart Fail. 2024 Aug; 11(4):2191-2199.
    View in: PubMed
    Score: 0.085
  21. Molecular determinants of altered contractility in heart failure. Ann Med. 2004; 36 Suppl 1:70-80.
    View in: PubMed
    Score: 0.083
  22. Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circ Heart Fail. 2023 12; 16(12):e010351.
    View in: PubMed
    Score: 0.083
  23. Common disease-promoting signalling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences. Cardiovasc Res. 2022 08 24; 118(11):2397-2399.
    View in: PubMed
    Score: 0.075
  24. Prolonged ?-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure. Elife. 2022 08 01; 11.
    View in: PubMed
    Score: 0.075
  25. Myocardial disease in failing hearts: defective excitation-contraction coupling. Cold Spring Harb Symp Quant Biol. 2002; 67:533-41.
    View in: PubMed
    Score: 0.072
  26. SPEG: a key regulator of cardiac calcium homeostasis. Cardiovasc Res. 2021 08 29; 117(10):2175-2185.
    View in: PubMed
    Score: 0.070
  27. Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021; 17(11):2871-2883.
    View in: PubMed
    Score: 0.070
  28. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442.
    View in: PubMed
    Score: 0.061
  29. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071.
    View in: PubMed
    Score: 0.060
  30. Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262.
    View in: PubMed
    Score: 0.059
  31. Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling. J Cell Physiol. 2019 07; 234(7):11587-11601.
    View in: PubMed
    Score: 0.058
  32. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172.
    View in: PubMed
    Score: 0.050
  33. Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. Am J Physiol Heart Circ Physiol. 2014 Nov 01; 307(9):H1317-26.
    View in: PubMed
    Score: 0.043
  34. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014 Apr 29; 129(17):1742-50.
    View in: PubMed
    Score: 0.042
  35. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013; 8(9):e75882.
    View in: PubMed
    Score: 0.041
  36. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 01; 100(1):44-53.
    View in: PubMed
    Score: 0.040
  37. Worsening renal function is not associated with response to treatment in acute heart failure. Int J Cardiol. 2013 Sep 01; 167(5):1912-7.
    View in: PubMed
    Score: 0.037
  38. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83.
    View in: PubMed
    Score: 0.037
  39. Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol. 2012 Mar 13; 59(11):998-1005.
    View in: PubMed
    Score: 0.037
  40. Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship. Am Heart J. 2011 Mar; 161(3):567-73.
    View in: PubMed
    Score: 0.034
  41. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 08; 123(9):979-88.
    View in: PubMed
    Score: 0.034
  42. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb; 8(2):323-5.
    View in: PubMed
    Score: 0.033
  43. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70.
    View in: PubMed
    Score: 0.033
  44. Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data. Int J Cardiol. 2011 Aug 04; 150(3):264-9.
    View in: PubMed
    Score: 0.032
  45. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem. 2008 Aug 08; 283(32):22295-303.
    View in: PubMed
    Score: 0.028
  46. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35.
    View in: PubMed
    Score: 0.023
  47. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 2005 Jun 28; 111(25):3342-6.
    View in: PubMed
    Score: 0.023
  48. AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022.
    View in: PubMed
    Score: 0.021
  49. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 Apr 02; 94(6):e61-70.
    View in: PubMed
    Score: 0.021
  50. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci. 2003 Dec; 28(12):671-8.
    View in: PubMed
    Score: 0.021
  51. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20; 107(19):2459-66.
    View in: PubMed
    Score: 0.020
  52. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72.
    View in: PubMed
    Score: 0.012
  53. Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22.
    View in: PubMed
    Score: 0.010
  54. Diseases associated with altered ryanodine receptor activity. Subcell Biochem. 2007; 45:273-321.
    View in: PubMed
    Score: 0.006
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