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XANDER WEHRENS to Calcium

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This is a "connection" page, showing publications XANDER WEHRENS has written about Calcium.
XANDER WEHRENS
Connection Strength
7.658
Calcium
  1. Macrophage-mediated IL-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation. J Clin Invest. 2025 May 01; 135(9).
    View in: PubMed
    Score: 0.637
  2. Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity. Circ Arrhythm Electrophysiol. 2023 02; 16(2):e010858.
    View in: PubMed
    Score: 0.551
  3. SPEG: a key regulator of cardiac calcium homeostasis. Cardiovasc Res. 2021 08 29; 117(10):2175-2185.
    View in: PubMed
    Score: 0.499
  4. Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling. J Gen Physiol. 2020 11 02; 152(11).
    View in: PubMed
    Score: 0.472
  5. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 06 15; 595(12):4001-4008.
    View in: PubMed
    Score: 0.367
  6. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655.
    View in: PubMed
    Score: 0.278
  7. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun; 32(6):749-57.
    View in: PubMed
    Score: 0.246
  8. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin. 2010 Sep; 31(9):1019-21.
    View in: PubMed
    Score: 0.232
  9. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8.
    View in: PubMed
    Score: 0.225
  10. Stress synchronizes calcium release and promotes SR calcium leak. J Physiol. 2010 Feb 01; 588(Pt 3):391-2.
    View in: PubMed
    Score: 0.224
  11. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4.
    View in: PubMed
    Score: 0.223
  12. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54.
    View in: PubMed
    Score: 0.197
  13. Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem Soc Trans. 2007 Nov; 35(Pt 5):952-6.
    View in: PubMed
    Score: 0.192
  14. Intracellular calcium release and cardiac disease. Annu Rev Physiol. 2005; 67:69-98.
    View in: PubMed
    Score: 0.157
  15. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73.
    View in: PubMed
    Score: 0.152
  16. Ca2+/calmodulin-dependent kinase IIdC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak. ESC Heart Fail. 2024 Aug; 11(4):2191-2199.
    View in: PubMed
    Score: 0.150
  17. Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia. Arch Toxicol. 2023 01; 97(1):73-92.
    View in: PubMed
    Score: 0.135
  18. Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases. Expert Opin Ther Targets. 2022 04; 26(4):303-317.
    View in: PubMed
    Score: 0.131
  19. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 03; 17(3):503-511.
    View in: PubMed
    Score: 0.110
  20. Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling. J Cell Physiol. 2019 07; 234(7):11587-11601.
    View in: PubMed
    Score: 0.103
  21. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682.
    View in: PubMed
    Score: 0.099
  22. Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. J Mol Cell Cardiol. 2018 01; 114:1-9.
    View in: PubMed
    Score: 0.095
  23. Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017 06 15; 595(12):4089-4108.
    View in: PubMed
    Score: 0.091
  24. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22.
    View in: PubMed
    Score: 0.078
  25. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res. 2015 Jan 02; 116(1):e1-e10.
    View in: PubMed
    Score: 0.078
  26. Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice. Int J Cardiol. 2014 Oct 20; 176(3):994-1000.
    View in: PubMed
    Score: 0.077
  27. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83.
    View in: PubMed
    Score: 0.076
  28. Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases. Cardiovasc Res. 2014 Jul 15; 103(2):198-205.
    View in: PubMed
    Score: 0.076
  29. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285.
    View in: PubMed
    Score: 0.074
  30. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14; 129(2):145-156.
    View in: PubMed
    Score: 0.073
  31. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 01; 100(1):44-53.
    View in: PubMed
    Score: 0.070
  32. Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry? Acta Physiol (Oxf). 2013 Feb; 207(2):208-11.
    View in: PubMed
    Score: 0.069
  33. Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22.
    View in: PubMed
    Score: 0.069
  34. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70.
    View in: PubMed
    Score: 0.065
  35. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 03; 110(3):465-70.
    View in: PubMed
    Score: 0.064
  36. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79.
    View in: PubMed
    Score: 0.059
  37. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 01; 89(4):734-43.
    View in: PubMed
    Score: 0.059
  38. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb; 8(2):323-5.
    View in: PubMed
    Score: 0.059
  39. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70.
    View in: PubMed
    Score: 0.058
  40. Animal models of arrhythmogenic cardiomyopathy. Dis Model Mech. 2009 Nov-Dec; 2(11-12):563-70.
    View in: PubMed
    Score: 0.055
  41. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51.
    View in: PubMed
    Score: 0.054
  42. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17.
    View in: PubMed
    Score: 0.047
  43. Ryanodine receptors as pharmacological targets for heart disease. Acta Pharmacol Sin. 2007 Jul; 28(7):937-44.
    View in: PubMed
    Score: 0.047
  44. Diseases associated with altered ryanodine receptor activity. Subcell Biochem. 2007; 45:273-321.
    View in: PubMed
    Score: 0.045
  45. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7906-10.
    View in: PubMed
    Score: 0.043
  46. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 2005 Jun 28; 111(25):3342-6.
    View in: PubMed
    Score: 0.041
  47. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation. 2004 Jun 29; 109(25):3208-14.
    View in: PubMed
    Score: 0.038
  48. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004 Apr 09; 304(5668):292-6.
    View in: PubMed
    Score: 0.037
  49. AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022.
    View in: PubMed
    Score: 0.037
  50. Molecular determinants of altered contractility in heart failure. Ann Med. 2004; 36 Suppl 1:70-80.
    View in: PubMed
    Score: 0.037
  51. An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor. Sci Transl Med. 2023 06 21; 15(701):eabq7839.
    View in: PubMed
    Score: 0.035
  52. Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice. Cardiovasc Res. 2022 10 21; 118(13):2805-2818.
    View in: PubMed
    Score: 0.034
  53. Prolonged ?-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure. Elife. 2022 08 01; 11.
    View in: PubMed
    Score: 0.033
  54. Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis. Circulation. 2000 Aug 01; 102(5):584-90.
    View in: PubMed
    Score: 0.029
  55. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 08 20; 140(8):681-693.
    View in: PubMed
    Score: 0.027
  56. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 11 13; 138(20):2227-2242.
    View in: PubMed
    Score: 0.026
  57. EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586.
    View in: PubMed
    Score: 0.024
  58. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 02; 103:110-120.
    View in: PubMed
    Score: 0.023
  59. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903.
    View in: PubMed
    Score: 0.022
  60. Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H713-24.
    View in: PubMed
    Score: 0.022
  61. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72.
    View in: PubMed
    Score: 0.022
  62. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol. 2016 06 01; 594(11):3005-30.
    View in: PubMed
    Score: 0.021
  63. Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016 Mar; 111(2):15.
    View in: PubMed
    Score: 0.021
  64. CaMKIId mediates ?-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ?-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91.
    View in: PubMed
    Score: 0.020
  65. The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20; 6:6081.
    View in: PubMed
    Score: 0.020
  66. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 01; 101(1):165-74.
    View in: PubMed
    Score: 0.018
  67. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013; 8(9):e75882.
    View in: PubMed
    Score: 0.018
  68. Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res. 2013 Oct 01; 100(1):54-62.
    View in: PubMed
    Score: 0.018
  69. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep; 53(3):429-36.
    View in: PubMed
    Score: 0.017
  70. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 05; 125(22):2751-61.
    View in: PubMed
    Score: 0.016
  71. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5972-7.
    View in: PubMed
    Score: 0.013
  72. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 2009 Apr; 106(4):1280-92.
    View in: PubMed
    Score: 0.013
  73. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32.
    View in: PubMed
    Score: 0.010
  74. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1267-79.
    View in: PubMed
    Score: 0.010
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