Connection

XANDER WEHRENS to Animals

This is a "connection" page, showing publications XANDER WEHRENS has written about Animals.
Connection Strength

2.273
  1. Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement. Clin Sci (Lond). 2024 Sep 18; 138(18):1173-1177.
    View in: PubMed
    Score: 0.042
  2. A mechanistic LNK between inflammation and atrial fibrillation? Cardiovasc Res. 2024 Jul 02; 120(8):814-816.
    View in: PubMed
    Score: 0.041
  3. Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies. Life Sci Alliance. 2024 May; 7(5).
    View in: PubMed
    Score: 0.040
  4. In Vivo Cardiac Electrophysiology in Mice: Determination of Atrial and Ventricular Arrhythmic Substrates. Curr Protoc. 2024 Feb; 4(2):e994.
    View in: PubMed
    Score: 0.040
  5. Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity. Circ Arrhythm Electrophysiol. 2023 02; 16(2):e010858.
    View in: PubMed
    Score: 0.037
  6. Mouse models of spontaneous atrial fibrillation. Mamm Genome. 2023 Jun; 34(2):298-311.
    View in: PubMed
    Score: 0.036
  7. Cellular regeneration as a potential strategy to treat cardiac conduction disorders. J Clin Invest. 2021 10 01; 131(19).
    View in: PubMed
    Score: 0.034
  8. Atrial-Specific LKB1 Knockdown Represents a Novel Mouse Model of Atrial Cardiomyopathy With Spontaneous Atrial Fibrillation. Circulation. 2021 09 14; 144(11):909-912.
    View in: PubMed
    Score: 0.034
  9. SPEG: a key regulator of cardiac calcium homeostasis. Cardiovasc Res. 2021 08 29; 117(10):2175-2185.
    View in: PubMed
    Score: 0.034
  10. Mechanisms underlying pathological Ca2+ handling in diseases of the heart. Pflugers Arch. 2021 03; 473(3):331-347.
    View in: PubMed
    Score: 0.032
  11. Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling. J Gen Physiol. 2020 11 02; 152(11).
    View in: PubMed
    Score: 0.032
  12. Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies. Cardiovasc Res. 2020 07 15; 116(9):1600-1619.
    View in: PubMed
    Score: 0.031
  13. Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling. Basic Res Cardiol. 2020 06 26; 115(4):49.
    View in: PubMed
    Score: 0.031
  14. Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure. Expert Opin Ther Targets. 2020 01; 24(1):25-36.
    View in: PubMed
    Score: 0.030
  15. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 06 20; 4(12).
    View in: PubMed
    Score: 0.029
  16. Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262.
    View in: PubMed
    Score: 0.028
  17. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Circulation. 2018 10 09; 138(15):1569-1581.
    View in: PubMed
    Score: 0.028
  18. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 Sep 28; 123(8):953-963.
    View in: PubMed
    Score: 0.028
  19. Mouse Models of Cardiac Arrhythmias. Circ Res. 2018 07 20; 123(3):332-334.
    View in: PubMed
    Score: 0.027
  20. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682.
    View in: PubMed
    Score: 0.027
  21. Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. J Mol Cell Cardiol. 2018 01; 114:1-9.
    View in: PubMed
    Score: 0.026
  22. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993.
    View in: PubMed
    Score: 0.025
  23. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 06 15; 595(12):4001-4008.
    View in: PubMed
    Score: 0.025
  24. Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs. Int J Cardiol. 2017 Jan 15; 227:668-673.
    View in: PubMed
    Score: 0.024
  25. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017 Jan 06; 120(1):110-119.
    View in: PubMed
    Score: 0.024
  26. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol. 2016 Dec 15; 225:371-380.
    View in: PubMed
    Score: 0.024
  27. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172.
    View in: PubMed
    Score: 0.024
  28. Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):177-84.
    View in: PubMed
    Score: 0.023
  29. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505.
    View in: PubMed
    Score: 0.022
  30. It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5.
    View in: PubMed
    Score: 0.022
  31. Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice. Int J Cardiol. 2014 Oct 20; 176(3):994-1000.
    View in: PubMed
    Score: 0.021
  32. Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. Am J Physiol Heart Circ Physiol. 2014 Nov 01; 307(9):H1317-26.
    View in: PubMed
    Score: 0.021
  33. Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases. Cardiovasc Res. 2014 Jul 15; 103(2):198-205.
    View in: PubMed
    Score: 0.020
  34. Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 01; 103(1):178-87.
    View in: PubMed
    Score: 0.020
  35. Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res. 2014 Apr 11; 114(8):1311-9; discussion 1319.
    View in: PubMed
    Score: 0.020
  36. Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. J Am Coll Cardiol. 2013 Nov 19; 62(21):2010-9.
    View in: PubMed
    Score: 0.019
  37. Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta. 2013 Dec; 1832(12):2425-31.
    View in: PubMed
    Score: 0.019
  38. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 01; 100(1):44-53.
    View in: PubMed
    Score: 0.019
  39. Chronic exercise: a contributing factor to atrial fibrillation? J Am Coll Cardiol. 2013 Jul 02; 62(1):78-80.
    View in: PubMed
    Score: 0.019
  40. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655.
    View in: PubMed
    Score: 0.019
  41. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr; 10(4):592-9.
    View in: PubMed
    Score: 0.018
  42. Extinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm. 2013 Jan; 10(1):108-9.
    View in: PubMed
    Score: 0.018
  43. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 03; 110(3):465-70.
    View in: PubMed
    Score: 0.017
  44. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun; 32(6):749-57.
    View in: PubMed
    Score: 0.017
  45. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 08; 123(9):979-88.
    View in: PubMed
    Score: 0.016
  46. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79.
    View in: PubMed
    Score: 0.016
  47. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 01; 89(4):734-43.
    View in: PubMed
    Score: 0.016
  48. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb; 8(2):323-5.
    View in: PubMed
    Score: 0.016
  49. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin. 2010 Sep; 31(9):1019-21.
    View in: PubMed
    Score: 0.016
  50. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70.
    View in: PubMed
    Score: 0.016
  51. Transthoracic echocardiography in mice. J Vis Exp. 2010 May 28; (39).
    View in: PubMed
    Score: 0.015
  52. Ambulatory ECG recording in mice. J Vis Exp. 2010 May 27; (39).
    View in: PubMed
    Score: 0.015
  53. Programmed electrical stimulation in mice. J Vis Exp. 2010 May 26; (39).
    View in: PubMed
    Score: 0.015
  54. Transverse aortic constriction in mice. J Vis Exp. 2010 Apr 21; (38).
    View in: PubMed
    Score: 0.015
  55. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8.
    View in: PubMed
    Score: 0.015
  56. Stress synchronizes calcium release and promotes SR calcium leak. J Physiol. 2010 Feb 01; 588(Pt 3):391-2.
    View in: PubMed
    Score: 0.015
  57. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4.
    View in: PubMed
    Score: 0.015
  58. Animal models of arrhythmogenic cardiomyopathy. Dis Model Mech. 2009 Nov-Dec; 2(11-12):563-70.
    View in: PubMed
    Score: 0.015
  59. Molecular evolution of the junctophilin gene family. Physiol Genomics. 2009 May 13; 37(3):175-86.
    View in: PubMed
    Score: 0.014
  60. Alternative splicing: a key mechanism for ankyrin-B functional diversity? J Mol Cell Cardiol. 2008 Dec; 45(6):709-11.
    View in: PubMed
    Score: 0.014
  61. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54.
    View in: PubMed
    Score: 0.013
  62. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007 Oct; 22:342-50.
    View in: PubMed
    Score: 0.013
  63. Istaroxime, a novel luso-inotropic agent for the treatment of acute heart failure. Curr Opin Investig Drugs. 2007 Sep; 8(9):769-77.
    View in: PubMed
    Score: 0.013
  64. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17.
    View in: PubMed
    Score: 0.013
  65. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):511-8.
    View in: PubMed
    Score: 0.011
  66. Structural determinants of potassium channel blockade and drug-induced arrhythmias. Handb Exp Pharmacol. 2006; (171):123-57.
    View in: PubMed
    Score: 0.011
  67. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9607-12.
    View in: PubMed
    Score: 0.011
  68. Intracellular calcium release and cardiac disease. Annu Rev Physiol. 2005; 67:69-98.
    View in: PubMed
    Score: 0.011
  69. Junctophilin-2 Regulates Mitochondrial Metabolism. Circulation. 2024 Aug 20; 150(8):657-660.
    View in: PubMed
    Score: 0.010
  70. Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome. Circ Genom Precis Med. 2024 Aug; 17(4):e004614.
    View in: PubMed
    Score: 0.010
  71. Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. J Mol Cell Cardiol. 2024 Sep; 194:85-95.
    View in: PubMed
    Score: 0.010
  72. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73.
    View in: PubMed
    Score: 0.010
  73. Ca2+/calmodulin-dependent kinase IIdC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak. ESC Heart Fail. 2024 Aug; 11(4):2191-2199.
    View in: PubMed
    Score: 0.010
  74. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004 Apr 09; 304(5668):292-6.
    View in: PubMed
    Score: 0.010
  75. NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy. Genome Med. 2024 04 03; 16(1):53.
    View in: PubMed
    Score: 0.010
  76. AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022.
    View in: PubMed
    Score: 0.010
  77. Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-Ib?C-X mice with persistent atrial fibrillation. J Mol Cell Cardiol. 2024 May; 190:1-12.
    View in: PubMed
    Score: 0.010
  78. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 Apr 02; 94(6):e61-70.
    View in: PubMed
    Score: 0.010
  79. Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers. J Gen Physiol. 2024 Apr 01; 156(4).
    View in: PubMed
    Score: 0.010
  80. Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circ Heart Fail. 2023 12; 16(12):e010351.
    View in: PubMed
    Score: 0.010
  81. Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation. J Clin Invest. 2023 10 02; 133(19).
    View in: PubMed
    Score: 0.010
  82. PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation. Circ Res. 2023 10 13; 133(9):758-771.
    View in: PubMed
    Score: 0.010
  83. Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. Commun Biol. 2023 09 14; 6(1):942.
    View in: PubMed
    Score: 0.010
  84. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 2003 Jun 27; 113(7):829-40.
    View in: PubMed
    Score: 0.010
  85. An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor. Sci Transl Med. 2023 06 21; 15(701):eabq7839.
    View in: PubMed
    Score: 0.010
  86. Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16.
    View in: PubMed
    Score: 0.009
  87. Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice. Cardiovasc Res. 2022 10 21; 118(13):2805-2818.
    View in: PubMed
    Score: 0.009
  88. A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice. Am J Physiol Heart Circ Physiol. 2022 11 01; 323(5):H983-H995.
    View in: PubMed
    Score: 0.009
  89. Prolonged ?-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure. Elife. 2022 08 01; 11.
    View in: PubMed
    Score: 0.009
  90. Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation. Br J Surg. 2002 Feb; 89(2):185-91.
    View in: PubMed
    Score: 0.009
  91. Myocardial disease in failing hearts: defective excitation-contraction coupling. Cold Spring Harb Symp Quant Biol. 2002; 67:533-41.
    View in: PubMed
    Score: 0.009
  92. Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy. Oxid Med Cell Longev. 2021; 2021:5391706.
    View in: PubMed
    Score: 0.009
  93. Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021; 17(11):2871-2883.
    View in: PubMed
    Score: 0.008
  94. Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy. JCI Insight. 2021 03 08; 6(5).
    View in: PubMed
    Score: 0.008
  95. Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms. J Clin Invest. 2021 01 19; 131(2).
    View in: PubMed
    Score: 0.008
  96. Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. Nature. 2020 11; 587(7834):460-465.
    View in: PubMed
    Score: 0.008
  97. Use of an intact mouse skeletal muscle preparation for endocrine vascular studies: evaluation of the model. Horm Metab Res. 2000 Sep; 32(9):378-80.
    View in: PubMed
    Score: 0.008
  98. Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation. Circ Res. 2020 09 25; 127(8):1036-1055.
    View in: PubMed
    Score: 0.008
  99. Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation. Circulation. 2020 09 22; 142(12):1159-1172.
    View in: PubMed
    Score: 0.008
  100. Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy. Cardiovasc Res. 2020 05 01; 116(6):1199-1213.
    View in: PubMed
    Score: 0.008
  101. Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 04 01; 130(4):1713-1727.
    View in: PubMed
    Score: 0.008
  102. Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 03 04; 10(1):4043.
    View in: PubMed
    Score: 0.008
  103. Mouse electrocardiography: an interval of thirty years. Cardiovasc Res. 2000 Jan 01; 45(1):231-7.
    View in: PubMed
    Score: 0.008
  104. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 03; 17(3):503-511.
    View in: PubMed
    Score: 0.007
  105. The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury. Cardiovasc Drugs Ther. 2019 08; 33(4):489-498.
    View in: PubMed
    Score: 0.007
  106. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442.
    View in: PubMed
    Score: 0.007
  107. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 08 20; 140(8):681-693.
    View in: PubMed
    Score: 0.007
  108. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071.
    View in: PubMed
    Score: 0.007
  109. Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 03 01; 115(3):556-569.
    View in: PubMed
    Score: 0.007
  110. Protein Phosphatase 2A Regulates Cardiac Na+ Channels. Circ Res. 2019 03; 124(5):737-746.
    View in: PubMed
    Score: 0.007
  111. YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In?Vivo. Dev Cell. 2019 03 25; 48(6):765-779.e7.
    View in: PubMed
    Score: 0.007
  112. Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling. J Cell Physiol. 2019 07; 234(7):11587-11601.
    View in: PubMed
    Score: 0.007
  113. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 11 13; 138(20):2227-2242.
    View in: PubMed
    Score: 0.007
  114. CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. J Am Heart Assoc. 2018 10 02; 7(19):e010393.
    View in: PubMed
    Score: 0.007
  115. EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586.
    View in: PubMed
    Score: 0.007
  116. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017 Dec 08; 121(12):1346-1359.
    View in: PubMed
    Score: 0.006
  117. Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017 09 07; 2(17).
    View in: PubMed
    Score: 0.006
  118. Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform. FEBS Lett. 1997 Apr 01; 405(3):315-20.
    View in: PubMed
    Score: 0.006
  119. Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017 06 15; 595(12):4089-4108.
    View in: PubMed
    Score: 0.006
  120. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 02; 103:110-120.
    View in: PubMed
    Score: 0.006
  121. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644.
    View in: PubMed
    Score: 0.006
  122. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149.
    View in: PubMed
    Score: 0.006
  123. Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis. Hum Mol Genet. 2016 11 15; 25(22):4983-4995.
    View in: PubMed
    Score: 0.006
  124. Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci. 2016 12 01; 129(23):4388-4398.
    View in: PubMed
    Score: 0.006
  125. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903.
    View in: PubMed
    Score: 0.006
  126. Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H713-24.
    View in: PubMed
    Score: 0.006
  127. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72.
    View in: PubMed
    Score: 0.006
  128. Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016 08 12; 291(33):17247-57.
    View in: PubMed
    Score: 0.006
  129. Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. Cell Rep. 2016 06 07; 15(10):2200-2213.
    View in: PubMed
    Score: 0.006
  130. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol. 2016 06 01; 594(11):3005-30.
    View in: PubMed
    Score: 0.006
  131. A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003180.
    View in: PubMed
    Score: 0.006
  132. Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016 Mar; 111(2):15.
    View in: PubMed
    Score: 0.006
  133. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93.
    View in: PubMed
    Score: 0.006
  134. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016 Apr 01; 109(4):467-79.
    View in: PubMed
    Score: 0.006
  135. Protein phosphatase 2A regulatory subunit B56a limits phosphatase activity in the heart. Sci Signal. 2015 Jul 21; 8(386):ra72.
    View in: PubMed
    Score: 0.006
  136. Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circ Res. 2015 Aug 28; 117(6):536-46.
    View in: PubMed
    Score: 0.006
  137. PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71.
    View in: PubMed
    Score: 0.005
  138. CaMKIId mediates ?-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ?-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91.
    View in: PubMed
    Score: 0.005
  139. Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation. Heart Rhythm. 2015 Jun; 12(6):1352-61.
    View in: PubMed
    Score: 0.005
  140. Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. Dis Model Mech. 2015 Apr; 8(4):363-71.
    View in: PubMed
    Score: 0.005
  141. Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. J Am Coll Cardiol. 2015 Jan 20; 65(2):163-73.
    View in: PubMed
    Score: 0.005
  142. The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20; 6:6081.
    View in: PubMed
    Score: 0.005
  143. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFa. Nat Commun. 2015 Jan 19; 6:6018.
    View in: PubMed
    Score: 0.005
  144. Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophys J. 2014 Dec 16; 107(12):2815-2827.
    View in: PubMed
    Score: 0.005
  145. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22.
    View in: PubMed
    Score: 0.005
  146. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res. 2015 Jan 02; 116(1):e1-e10.
    View in: PubMed
    Score: 0.005
  147. Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic Res Cardiol. 2014; 109(6):447.
    View in: PubMed
    Score: 0.005
  148. TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process. Hypertension. 2014 Dec; 64(6):1260-5.
    View in: PubMed
    Score: 0.005
  149. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83.
    View in: PubMed
    Score: 0.005
  150. Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9181-6.
    View in: PubMed
    Score: 0.005
  151. Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nat Commun. 2014 Apr 22; 5:3603.
    View in: PubMed
    Score: 0.005
  152. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014 Apr 29; 129(17):1742-50.
    View in: PubMed
    Score: 0.005
  153. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285.
    View in: PubMed
    Score: 0.005
  154. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 01; 101(1):165-74.
    View in: PubMed
    Score: 0.005
  155. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013; 8(9):e75882.
    View in: PubMed
    Score: 0.005
  156. Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57.
    View in: PubMed
    Score: 0.005
  157. Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res. 2013 Oct 01; 100(1):54-62.
    View in: PubMed
    Score: 0.005
  158. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013 May 28; 25(4):417-26.
    View in: PubMed
    Score: 0.005
  159. Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry? Acta Physiol (Oxf). 2013 Feb; 207(2):208-11.
    View in: PubMed
    Score: 0.005
  160. Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22.
    View in: PubMed
    Score: 0.005
  161. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec; 9(12):2034-41.
    View in: PubMed
    Score: 0.005
  162. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep; 53(3):429-36.
    View in: PubMed
    Score: 0.004
  163. Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS One. 2012; 7(5):e36994.
    View in: PubMed
    Score: 0.004
  164. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 05; 125(22):2751-61.
    View in: PubMed
    Score: 0.004
  165. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83.
    View in: PubMed
    Score: 0.004
  166. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70.
    View in: PubMed
    Score: 0.004
  167. Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys J. 2012 03 07; 102(5):L19-21.
    View in: PubMed
    Score: 0.004
  168. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22; 483(7387):96-9.
    View in: PubMed
    Score: 0.004
  169. Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med. 2011 Dec 14; 3(113):113ra125.
    View in: PubMed
    Score: 0.004
  170. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20; 166(2):366-74.
    View in: PubMed
    Score: 0.004
  171. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22.
    View in: PubMed
    Score: 0.004
  172. Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J Mol Cell Cardiol. 2011 Dec; 51(6):936-44.
    View in: PubMed
    Score: 0.004
  173. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar; 4(2):214-23.
    View in: PubMed
    Score: 0.004
  174. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9753-8.
    View in: PubMed
    Score: 0.004
  175. Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15; 19(6):1066-75.
    View in: PubMed
    Score: 0.004
  176. Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):677-85.
    View in: PubMed
    Score: 0.004
  177. PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest. 2009 Dec; 119(12):3797-806.
    View in: PubMed
    Score: 0.004
  178. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51.
    View in: PubMed
    Score: 0.004
  179. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5972-7.
    View in: PubMed
    Score: 0.004
  180. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 2009 Apr; 106(4):1280-92.
    View in: PubMed
    Score: 0.004
  181. 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet. 2009 Mar; 46(3):168-75.
    View in: PubMed
    Score: 0.003
  182. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem. 2008 Aug 08; 283(32):22295-303.
    View in: PubMed
    Score: 0.003
  183. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12179-84.
    View in: PubMed
    Score: 0.003
  184. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7906-10.
    View in: PubMed
    Score: 0.003
  185. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3456-61.
    View in: PubMed
    Score: 0.003
  186. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35.
    View in: PubMed
    Score: 0.003
  187. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32.
    View in: PubMed
    Score: 0.003
  188. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1267-79.
    View in: PubMed
    Score: 0.003
  189. Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovasc Res. 2002 Sep; 55(4):768-77.
    View in: PubMed
    Score: 0.002
  190. Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin. J Invest Dermatol. 2002 Feb; 118(2):323-6.
    View in: PubMed
    Score: 0.002
  191. Microcirculatory effects of experimental acute limb ischaemia-reperfusion. Br J Surg. 2001 Jun; 88(6):816-24.
    View in: PubMed
    Score: 0.002
  192. Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. Cell Struct Funct. 1997 Feb; 22(1):65-72.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.