OLIVIER LICHTARGE to Computational Biology
This is a "connection" page, showing publications OLIVIER LICHTARGE has written about Computational Biology.
Connection Strength
7.971
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Meta-EA: a gene-specific combination of available computational tools for predicting missense variant effects. Nat Commun. 2025 Jan 02; 16(1):159.
Score: 0.685
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An Evolutionary Trace method defines functionally important bases and sites common to RNA families. PLoS Comput Biol. 2020 03; 16(3):e1007583.
Score: 0.492
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Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks. Pac Symp Biocomput. 2020; 25:439-450.
Score: 0.484
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CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation. Hum Mutat. 2019 09; 40(9):1436-1454.
Score: 0.471
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Multimodal network diffusion predicts future disease-gene-chemical associations. Bioinformatics. 2019 05 01; 35(9):1536-1543.
Score: 0.462
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Objective assessment of the evolutionary action equation for the fitness effect of missense mutations across CAGI-blinded contests. Hum Mutat. 2017 09; 38(9):1072-1084.
Score: 0.406
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Prediction and redesign of protein-protein interactions. Prog Biophys Mol Biol. 2014 Nov-Dec; 116(2-3):194-202.
Score: 0.328
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Prediction and experimental validation of enzyme substrate specificity in protein structures. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):E4195-202.
Score: 0.315
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ETAscape: analyzing protein networks to predict enzymatic function and substrates in Cytoscape. Bioinformatics. 2012 Aug 15; 28(16):2186-8.
Score: 0.287
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Evolutionary Trace Annotation Server: automated enzyme function prediction in protein structures using 3D templates. Bioinformatics. 2009 Jun 01; 25(11):1426-7.
Score: 0.229
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Rapid detection of similarity in protein structure and function through contact metric distances. Nucleic Acids Res. 2006; 34(22):e152.
Score: 0.195
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Rank information: a structure-independent measure of evolutionary trace quality that improves identification of protein functional sites. Proteins. 2006 Oct 01; 65(1):111-23.
Score: 0.193
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ET viewer: an application for predicting and visualizing functional sites in protein structures. Bioinformatics. 2006 Aug 15; 22(16):2049-50.
Score: 0.190
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Evolutionary trace report_maker: a new type of service for comparative analysis of proteins. Bioinformatics. 2006 Jul 01; 22(13):1656-7.
Score: 0.188
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Evolutionary and structural feedback on selection of sequences for comparative analysis of proteins. Proteins. 2006 Apr 01; 63(1):87-99.
Score: 0.187
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An accurate, sensitive, and scalable method to identify functional sites in protein structures. J Mol Biol. 2003 Feb 07; 326(1):255-61.
Score: 0.150
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Genome interpretation using in silico predictors of variant impact. Hum Genet. 2022 Oct; 141(10):1549-1577.
Score: 0.142
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Structural clusters of evolutionary trace residues are statistically significant and common in proteins. J Mol Biol. 2002 Feb 08; 316(1):139-54.
Score: 0.140
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Getting past appearances: the many-fold consequences of remote homology. Nat Struct Biol. 2001 Nov; 8(11):918-20.
Score: 0.137
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Assessing predictions on fitness effects of missense variants in calmodulin. Hum Mutat. 2019 09; 40(9):1463-1473.
Score: 0.118
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Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants. Hum Mutat. 2019 09; 40(9):1530-1545.
Score: 0.118
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CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases. Hum Mutat. 2019 09; 40(9):1373-1391.
Score: 0.118
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Assessment of predicted enzymatic activity of a-N-acetylglucosaminidase variants of unknown significance for CAGI 2016. Hum Mutat. 2019 09; 40(9):1519-1529.
Score: 0.118
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Assessment of blind predictions of the clinical significance of BRCA1 and BRCA2 variants. Hum Mutat. 2019 09; 40(9):1546-1556.
Score: 0.118
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Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer. Hum Mutat. 2019 09; 40(9):1612-1622.
Score: 0.118
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Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5. Hum Mutat. 2019 09; 40(9):1474-1485.
Score: 0.118
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Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI-5 intellectual disability challenge. Hum Mutat. 2019 09; 40(9):1330-1345.
Score: 0.117
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Assessment of methods for predicting the effects of PTEN and TPMT protein variants. Hum Mutat. 2019 09; 40(9):1495-1506.
Score: 0.117
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Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. Hum Mutat. 2017 09; 38(9):1042-1050.
Score: 0.101
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Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling. Hum Mutat. 2017 05; 38(5):569-580.
Score: 0.099
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DISCOVERY OF FUNCTIONAL AND DISEASE PATHWAYS BY COMMUNITY DETECTION IN PROTEIN-PROTEIN INTERACTION NETWORKS. Pac Symp Biocomput. 2017; 22:336-347.
Score: 0.098
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COMPUTING THERAPY FOR PRECISION MEDICINE: COLLABORATIVE FILTERING INTEGRATES AND PREDICTS MULTI-ENTITY INTERACTIONS. Pac Symp Biocomput. 2016; 21:21-32.
Score: 0.092
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Function prediction from networks of local evolutionary similarity in protein structure. BMC Bioinformatics. 2013; 14 Suppl 3:S6.
Score: 0.075
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A large-scale evaluation of computational protein function prediction. Nat Methods. 2013 Mar; 10(3):221-7.
Score: 0.075
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The use of evolutionary patterns in protein annotation. Curr Opin Struct Biol. 2012 Jun; 22(3):316-25.
Score: 0.071
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Sequence and structure continuity of evolutionary importance improves protein functional site discovery and annotation. Protein Sci. 2010 Jul; 19(7):1296-311.
Score: 0.063
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Evolution: a guide to perturb protein function and networks. Curr Opin Struct Biol. 2010 Jun; 20(3):351-9.
Score: 0.062
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The MASH pipeline for protein function prediction and an algorithm for the geometric refinement of 3D motifs. J Comput Biol. 2007 Jul-Aug; 14(6):791-816.
Score: 0.051
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Recurrent use of evolutionary importance for functional annotation of proteins based on local structural similarity. Protein Sci. 2006 Jun; 15(6):1530-6.
Score: 0.047
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Cavity-aware motifs reduce false positives in protein function prediction. Comput Syst Bioinformatics Conf. 2006; 311-23.
Score: 0.046
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Correlated evolutionary pressure at interacting transcription factors and DNA response elements can guide the rational engineering of DNA binding specificity. J Mol Biol. 2005 Jul 15; 350(3):402-15.
Score: 0.044
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Character and evolution of protein-protein interfaces. Phys Biol. 2005 Jun; 2(2):S36-43.
Score: 0.044
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Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. J Mol Biol. 2004 Nov 19; 344(2):303-10.
Score: 0.042
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ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J Biol Chem. 2024 Jun; 300(6):107368.
Score: 0.041
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Critical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project. Hum Genomics. 2024 04 29; 18(1):44.
Score: 0.041
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Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. Hum Mutat. 2019 09; 40(9):1314-1320.
Score: 0.029
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Benchmarking predictions of allostery in liver pyruvate kinase in CAGI4. Hum Mutat. 2017 09; 38(9):1123-1131.
Score: 0.025
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HUMAN KINASES DISPLAY MUTATIONAL HOTSPOTS AT COGNATE POSITIONS WITHIN CANCER. Pac Symp Biocomput. 2017; 22:414-425.
Score: 0.025
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REPURPOSING GERMLINE EXOMES OF THE CANCER GENOME ATLAS DEMANDS A CAUTIOUS APPROACH AND SAMPLE-SPECIFIC VARIANT FILTERING. Pac Symp Biocomput. 2016; 21:207-18.
Score: 0.023
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Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30; 290(5):2870-8.
Score: 0.021
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Algorithms for structural comparison and statistical analysis of 3D protein motifs. Pac Symp Biocomput. 2005; 334-45.
Score: 0.011