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TIMOTHY PALZKILL to Kinetics

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This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Kinetics.
TIMOTHY PALZKILL
Connection Strength
2.403
Kinetics
  1. Mechanistic Basis of OXA-48-like ?-Lactamases' Hydrolysis of Carbapenems. ACS Infect Dis. 2021 02 12; 7(2):445-460.
    View in: PubMed
    Score: 0.155
  2. KPC-2 ?-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J Biol Chem. 2021 Jan-Jun; 296:100155.
    View in: PubMed
    Score: 0.154
  3. Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018 11 16; 293(46):17971-17984.
    View in: PubMed
    Score: 0.132
  4. Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A ?-lactamases. BMC Biochem. 2017 03 06; 18(1):2.
    View in: PubMed
    Score: 0.118
  5. BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A ?-Lactamases. Biochemistry. 2017 02 28; 56(8):1075-1084.
    View in: PubMed
    Score: 0.118
  6. Engineering Specificity from Broad to Narrow: Design of a ?-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC ?-Lactamase. ACS Infect Dis. 2016 12 09; 2(12):969-979.
    View in: PubMed
    Score: 0.115
  7. Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-?-Lactamase is Fragile to Mutations. Sci Rep. 2016 09 12; 6:33195.
    View in: PubMed
    Score: 0.114
  8. Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry. 2016 05 03; 55(17):2479-90.
    View in: PubMed
    Score: 0.111
  9. A triple mutant in the O-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94.
    View in: PubMed
    Score: 0.103
  10. Role of ?-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II. Protein Sci. 2014 Sep; 23(9):1235-46.
    View in: PubMed
    Score: 0.098
  11. Identification of the ?-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A ?-lactamases. J Biol Chem. 2013 Jun 14; 288(24):17156-66.
    View in: PubMed
    Score: 0.091
  12. Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-?-lactamase active site. Antimicrob Agents Chemother. 2012 Nov; 56(11):5667-77.
    View in: PubMed
    Score: 0.086
  13. Analysis of the functional contributions of Asn233 in metallo-?-lactamase IMP-1. Antimicrob Agents Chemother. 2011 Dec; 55(12):5696-702.
    View in: PubMed
    Score: 0.081
  14. Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases. J Biol Chem. 2011 Sep 16; 286(37):32723-35.
    View in: PubMed
    Score: 0.080
  15. Identification of a ?-lactamase inhibitory protein variant that is a potent inhibitor of Staphylococcus PC1 ?-lactamase. J Mol Biol. 2011 Mar 11; 406(5):730-44.
    View in: PubMed
    Score: 0.077
  16. Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis. J Biol Chem. 2009 Nov 27; 284(48):33703-12.
    View in: PubMed
    Score: 0.071
  17. Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase. Protein Sci. 2009 Oct; 18(10):2080-9.
    View in: PubMed
    Score: 0.071
  18. Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase. J Mol Biol. 2008 Dec 05; 384(1):151-64.
    View in: PubMed
    Score: 0.066
  19. Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1. Antimicrob Agents Chemother. 2005 Aug; 49(8):3421-7.
    View in: PubMed
    Score: 0.053
  20. Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases. J Biol Chem. 2004 Oct 08; 279(41):42860-6.
    View in: PubMed
    Score: 0.049
  21. Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):541-5.
    View in: PubMed
    Score: 0.048
  22. Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J Biol Chem. 2003 Nov 14; 278(46):45706-12.
    View in: PubMed
    Score: 0.046
  23. Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis. Antimicrob Agents Chemother. 2003 Jun; 47(6):2040-2.
    View in: PubMed
    Score: 0.046
  24. An analysis of why highly similar enzymes evolve differently. Genetics. 2003 Feb; 163(2):457-66.
    View in: PubMed
    Score: 0.045
  25. Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection. Protein Sci. 2001 Dec; 10(12):2556-65.
    View in: PubMed
    Score: 0.041
  26. Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein. J Biol Chem. 2000 May 19; 275(20):14964-8.
    View in: PubMed
    Score: 0.037
  27. The role of residue 238 of TEM-1 beta-lactamase in the hydrolysis of extended-spectrum antibiotics. J Biol Chem. 1998 Oct 09; 273(41):26603-9.
    View in: PubMed
    Score: 0.033
  28. Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase. J Biol Chem. 1997 Nov 14; 272(46):29144-50.
    View in: PubMed
    Score: 0.031
  29. Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime. J Biol Chem. 1996 Sep 13; 271(37):22538-45.
    View in: PubMed
    Score: 0.029
  30. Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase. Antimicrob Agents Chemother. 1994 Oct; 38(10):2266-9.
    View in: PubMed
    Score: 0.025
  31. Characterization of TEM-1 beta-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime. J Biol Chem. 1994 Sep 23; 269(38):23444-50.
    View in: PubMed
    Score: 0.025
  32. Structural insight into the kinetics and DeltaCp of interactions between TEM-1 beta-lactamase and beta-lactamase inhibitory protein (BLIP). J Biol Chem. 2009 Jan 02; 284(1):595-609.
    View in: PubMed
    Score: 0.017
  33. Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89.
    View in: PubMed
    Score: 0.012
  34. A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):283-8.
    View in: PubMed
    Score: 0.010
  35. Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein Eng. 2000 Apr; 13(4):267-74.
    View in: PubMed
    Score: 0.009
  36. The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 beta-lactamase is the trans to cis isomerization of a non-proline peptide bond. Proteins. 1996 May; 25(1):104-11.
    View in: PubMed
    Score: 0.007
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