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TIMOTHY PALZKILL to Models, Molecular

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This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Models, Molecular.
TIMOTHY PALZKILL
Connection Strength
4.142
Models, Molecular
  1. Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J Biol Chem. 2024 01; 300(1):105493.
    View in: PubMed
    Score: 0.687
  2. The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry. 2017 07 11; 56(27):3443-3453.
    View in: PubMed
    Score: 0.441
  3. Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability. PLoS Pathog. 2015 Jun; 11(6):e1004949.
    View in: PubMed
    Score: 0.382
  4. Mutagenesis and structural analysis reveal the CTX-M ?-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J Biol Chem. 2023 05; 299(5):104630.
    View in: PubMed
    Score: 0.164
  5. Deep Sequencing of a Systematic Peptide Library Reveals Conformationally-Constrained Protein Interface Peptides that Disrupt a Protein-Protein Interaction. Chembiochem. 2022 02 04; 23(3):e202100504.
    View in: PubMed
    Score: 0.150
  6. Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 ?-lactamase. J Biol Chem. 2021 Jan-Jun; 296:100799.
    View in: PubMed
    Score: 0.144
  7. KPC-2 ?-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J Biol Chem. 2021 Jan-Jun; 296:100155.
    View in: PubMed
    Score: 0.140
  8. BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A ?-Lactamases. Biochemistry. 2017 02 28; 56(8):1075-1084.
    View in: PubMed
    Score: 0.108
  9. Engineering Specificity from Broad to Narrow: Design of a ?-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC ?-Lactamase. ACS Infect Dis. 2016 12 09; 2(12):969-979.
    View in: PubMed
    Score: 0.105
  10. Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry. 2016 05 03; 55(17):2479-90.
    View in: PubMed
    Score: 0.102
  11. A triple mutant in the O-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94.
    View in: PubMed
    Score: 0.094
  12. Role of ?-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II. Protein Sci. 2014 Sep; 23(9):1235-46.
    View in: PubMed
    Score: 0.090
  13. Identification of the ?-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A ?-lactamases. J Biol Chem. 2013 Jun 14; 288(24):17156-66.
    View in: PubMed
    Score: 0.083
  14. Deep sequencing of systematic combinatorial libraries reveals ?-lactamase sequence constraints at high resolution. J Mol Biol. 2012 Dec 07; 424(3-4):150-67.
    View in: PubMed
    Score: 0.079
  15. Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-?-lactamase active site. Antimicrob Agents Chemother. 2012 Nov; 56(11):5667-77.
    View in: PubMed
    Score: 0.079
  16. Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase. Protein Sci. 2011 Nov; 20(11):1891-906.
    View in: PubMed
    Score: 0.074
  17. Analysis of the functional contributions of Asn233 in metallo-?-lactamase IMP-1. Antimicrob Agents Chemother. 2011 Dec; 55(12):5696-702.
    View in: PubMed
    Score: 0.074
  18. Co-crystal structures of PKG I? (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413.
    View in: PubMed
    Score: 0.072
  19. Identification of a ?-lactamase inhibitory protein variant that is a potent inhibitor of Staphylococcus PC1 ?-lactamase. J Mol Biol. 2011 Mar 11; 406(5):730-44.
    View in: PubMed
    Score: 0.070
  20. Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM ?-lactamases. J Mol Biol. 2010 Dec 17; 404(5):832-46.
    View in: PubMed
    Score: 0.069
  21. Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display. Protein Eng Des Sel. 2010 Jun; 23(6):469-78.
    View in: PubMed
    Score: 0.067
  22. Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis. J Biol Chem. 2009 Nov 27; 284(48):33703-12.
    View in: PubMed
    Score: 0.065
  23. Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1. Antimicrob Agents Chemother. 2005 Aug; 49(8):3421-7.
    View in: PubMed
    Score: 0.048
  24. Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1. J Mol Biol. 2004 Nov 26; 344(3):653-63.
    View in: PubMed
    Score: 0.046
  25. Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases. J Biol Chem. 2004 Oct 08; 279(41):42860-6.
    View in: PubMed
    Score: 0.045
  26. A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays. Protein Eng. 2003 Nov; 16(11):853-60.
    View in: PubMed
    Score: 0.043
  27. Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J Biol Chem. 2003 Nov 14; 278(46):45706-12.
    View in: PubMed
    Score: 0.042
  28. Amino acid sequence requirements at residues 69 and 238 for the SME-1 beta-lactamase to confer resistance to beta-lactam antibiotics. Antimicrob Agents Chemother. 2003 Mar; 47(3):1062-7.
    View in: PubMed
    Score: 0.041
  29. Binding properties of a peptide derived from beta-lactamase inhibitory protein. Antimicrob Agents Chemother. 2001 Dec; 45(12):3279-86.
    View in: PubMed
    Score: 0.037
  30. Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection. Protein Sci. 2001 Dec; 10(12):2556-65.
    View in: PubMed
    Score: 0.037
  31. QM/MM modeling of class A ?-lactamases reveals distinct acylation pathways for ampicillin and cefalexin. Org Biomol Chem. 2021 Nov 03; 19(42):9182-9189.
    View in: PubMed
    Score: 0.037
  32. Amino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase. J Biol Chem. 2001 Dec 07; 276(49):46568-74.
    View in: PubMed
    Score: 0.037
  33. DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).
    View in: PubMed
    Score: 0.037
  34. Protein minimization by random fragmentation and selection. Protein Eng. 2001 Jul; 14(7):487-92.
    View in: PubMed
    Score: 0.036
  35. Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein. J Biol Chem. 2000 May 19; 275(20):14964-8.
    View in: PubMed
    Score: 0.034
  36. Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein Eng. 2000 Apr; 13(4):267-74.
    View in: PubMed
    Score: 0.033
  37. Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae. J Bacteriol. 2019 10 15; 201(20).
    View in: PubMed
    Score: 0.032
  38. Susceptibility of beta-lactamase to core amino acid substitutions. Protein Eng. 1999 Sep; 12(9):761-9.
    View in: PubMed
    Score: 0.032
  39. Amino acid sequence determinants of beta-lactamase structure and activity. J Mol Biol. 1996 May 17; 258(4):688-703.
    View in: PubMed
    Score: 0.026
  40. Molecular basis for the catalytic specificity of the CTX-M extended-spectrum ?-lactamases. Biochemistry. 2015 Jan 20; 54(2):447-57.
    View in: PubMed
    Score: 0.023
  41. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92.
    View in: PubMed
    Score: 0.020
  42. Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins. 1992 Sep; 14(1):29-44.
    View in: PubMed
    Score: 0.020
  43. 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-?-lactamases. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6229-32.
    View in: PubMed
    Score: 0.020
  44. Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity. J Virol. 2012 Oct; 86(19):10547-57.
    View in: PubMed
    Score: 0.020
  45. Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology. 2008 Mar 30; 373(1):211-28.
    View in: PubMed
    Score: 0.014
  46. Thermodynamic investigation of the role of contact residues of beta-lactamase-inhibitory protein for binding to TEM-1 beta-lactamase. J Biol Chem. 2007 Jun 15; 282(24):17676-84.
    View in: PubMed
    Score: 0.014
  47. The D-methyl group in beta-lactamase evolution: evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99. Biochemistry. 2005 May 24; 44(20):7543-52.
    View in: PubMed
    Score: 0.012
  48. Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89.
    View in: PubMed
    Score: 0.011
  49. The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 beta-lactamase is the trans to cis isomerization of a non-proline peptide bond. Proteins. 1996 May; 25(1):104-11.
    View in: PubMed
    Score: 0.006
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