TIMOTHY PALZKILL to Bacterial Proteins
This is a "connection" page, showing publications TIMOTHY PALZKILL has written about Bacterial Proteins.
Connection Strength
6.950
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Deep Sequencing of a Systematic Peptide Library Reveals Conformationally-Constrained Protein Interface Peptides that Disrupt a Protein-Protein Interaction. Chembiochem. 2022 02 04; 23(3):e202100504.
Score: 0.505
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Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 ?-lactamase. J Biol Chem. 2021 Jan-Jun; 296:100799.
Score: 0.486
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Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. ACS Infect Dis. 2020 05 08; 6(5):1214-1227.
Score: 0.449
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Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A ?-lactamases. BMC Biochem. 2017 03 06; 18(1):2.
Score: 0.363
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BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A ?-Lactamases. Biochemistry. 2017 02 28; 56(8):1075-1084.
Score: 0.362
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Engineering Specificity from Broad to Narrow: Design of a ?-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC ?-Lactamase. ACS Infect Dis. 2016 12 09; 2(12):969-979.
Score: 0.354
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Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-?-Lactamase is Fragile to Mutations. Sci Rep. 2016 09 12; 6:33195.
Score: 0.351
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Identification of the ?-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A ?-lactamases. J Biol Chem. 2013 Jun 14; 288(24):17156-66.
Score: 0.278
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BLIP-II is a highly potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2). Antimicrob Agents Chemother. 2013 Jul; 57(7):3398-401.
Score: 0.277
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Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases. J Biol Chem. 2011 Sep 16; 286(37):32723-35.
Score: 0.246
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Identification of a ?-lactamase inhibitory protein variant that is a potent inhibitor of Staphylococcus PC1 ?-lactamase. J Mol Biol. 2011 Mar 11; 406(5):730-44.
Score: 0.237
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Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display. Protein Eng Des Sel. 2010 Jun; 23(6):469-78.
Score: 0.224
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Fine mapping of the sequence requirements for binding of beta-lactamase inhibitory protein (BLIP) to TEM-1 beta-lactamase using a genetic screen for BLIP function. J Mol Biol. 2009 Jun 05; 389(2):401-12.
Score: 0.210
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Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa. J Biol Chem. 2005 May 06; 280(18):17786-91.
Score: 0.158
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The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrob Agents Chemother. 2024 03 06; 68(3):e0110823.
Score: 0.146
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Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J Biol Chem. 2024 01; 300(1):105493.
Score: 0.145
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Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J Biol Chem. 2003 Nov 14; 278(46):45706-12.
Score: 0.142
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Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery. Genome Res. 2003 Jul; 13(7):1665-74.
Score: 0.140
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Unveiling the structural features that regulate carbapenem deacylation in KPC-2 through QM/MM and interpretable machine learning. Phys Chem Chem Phys. 2023 Jan 04; 25(2):1349-1362.
Score: 0.136
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Binding properties of a peptide derived from beta-lactamase inhibitory protein. Antimicrob Agents Chemother. 2001 Dec; 45(12):3279-86.
Score: 0.126
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Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. ACS Infect Dis. 2021 12 10; 7(12):3345-3354.
Score: 0.126
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Use of the arabinose p(bad) promoter for tightly regulated display of proteins on bacteriophage. Gene. 2000 Jun 27; 251(2):187-97.
Score: 0.114
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Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein. J Biol Chem. 2000 May 19; 275(20):14964-8.
Score: 0.113
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A Standard Numbering Scheme for Class C ?-Lactamases. Antimicrob Agents Chemother. 2020 02 21; 64(3).
Score: 0.111
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Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae. J Bacteriol. 2019 10 15; 201(20).
Score: 0.108
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Identification of residues in beta-lactamase critical for binding beta-lactamase inhibitory protein. J Biol Chem. 1999 Mar 12; 274(11):6963-71.
Score: 0.104
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Contributions of aspartate 49 and phenylalanine 142 residues of a tight binding inhibitory protein of beta-lactamases. J Biol Chem. 1999 Jan 22; 274(4):2394-400.
Score: 0.103
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Amino acid sequence determinants of beta-lactamase structure and activity. J Mol Biol. 1996 May 17; 258(4):688-703.
Score: 0.086
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Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of beta-lactamase. Mol Microbiol. 1994 Apr; 12(2):217-29.
Score: 0.074
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Identification of novel and cross-species seroreactive proteins from Bacillus anthracis using a ligation-independent cloning-based, SOS-inducible expression system. Microb Pathog. 2012 Nov-Dec; 53(5-6):250-8.
Score: 0.067
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Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins. 1992 Sep; 14(1):29-44.
Score: 0.066
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An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes. Mol Microbiol. 2011 Dec; 82(6):1481-95.
Score: 0.063
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Structural insight into the kinetics and DeltaCp of interactions between TEM-1 beta-lactamase and beta-lactamase inhibitory protein (BLIP). J Biol Chem. 2009 Jan 02; 284(1):595-609.
Score: 0.051
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Generation and validation of a Shewanella oneidensis MR-1 clone set for protein expression and phage display. PLoS One. 2008 Aug 20; 3(8):e2983.
Score: 0.050
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A high-throughput percentage-of-binding strategy to measure binding energies in DNA-protein interactions: application to genome-scale site discovery. Nucleic Acids Res. 2008 Sep; 36(15):4863-71.
Score: 0.050
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The binary protein interactome of Treponema pallidum--the syphilis spirochete. PLoS One. 2008 May 28; 3(5):e2292.
Score: 0.049
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The protein network of bacterial motility. Mol Syst Biol. 2007; 3:128.
Score: 0.047
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Thermodynamic investigation of the role of contact residues of beta-lactamase-inhibitory protein for binding to TEM-1 beta-lactamase. J Biol Chem. 2007 Jun 15; 282(24):17676-84.
Score: 0.046
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Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome. J Clin Microbiol. 2006 Mar; 44(3):888-91.
Score: 0.042
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Finding new antibiotics: the power of computational methods. Drug Discov Today. 2002 Mar 15; 7(6):347-8.
Score: 0.032
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Protein minimization by random fragmentation and selection. Protein Eng. 2001 Jul; 14(7):487-92.
Score: 0.031
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Human immune response to streptococcal inhibitor of complement, a serotype M1 group A Streptococcus extracellular protein involved in epidemics. J Infect Dis. 2000 Nov; 182(5):1425-36.
Score: 0.029
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Reduced In Vitro Susceptibility of Streptococcus pyogenes to ?-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread. J Clin Microbiol. 2020 03 25; 58(4).
Score: 0.028
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Physiological roles of ArcA, Crp, and EtrA and their interactive control on aerobic and anaerobic respiration in Shewanella oneidensis. PLoS One. 2010 Dec 28; 5(12):e15295.
Score: 0.015
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Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response. J Bacteriol. 2002 Nov; 184(22):6316-24.
Score: 0.008