TOM COOPER to Humans
This is a "connection" page, showing publications TOM COOPER has written about Humans.
Connection Strength
0.620
-
MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model. J Clin Invest. 2025 Feb 11; 135(7).
Score: 0.025
-
Small Molecule Screening Identifies HSP90 as a Modifier of RNA Foci in Myotonic Dystrophy Type 1. Mol Cell Biol. 2025; 45(6):225-237.
Score: 0.024
-
Rescue of Scn5a mis-splicing does not improve the structural and functional heart defects of a DM1 heart mouse model. Hum Mol Genet. 2024 10 07; 33(20):1789-1799.
Score: 0.024
-
Insights into Cell-Specific Functions of Microtubules in Skeletal Muscle Development and Homeostasis. Int J Mol Sci. 2023 Feb 02; 24(3).
Score: 0.021
-
Clinical and Molecular Insights into Gastrointestinal Dysfunction in Myotonic Dystrophy Types 1 & 2. Int J Mol Sci. 2022 Nov 26; 23(23).
Score: 0.021
-
Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting. Hum Mol Genet. 2020 06 27; 29(10):1729-1744.
Score: 0.018
-
Endurance exercise leads to beneficial molecular and physiological effects in a mouse model of myotonic dystrophy type 1. Muscle Nerve. 2019 12; 60(6):779-789.
Score: 0.017
-
Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1. Hum Mol Genet. 2018 08 15; 27(16):2789-2804.
Score: 0.016
-
Protein sequestration as a normal function of long noncoding RNAs and a pathogenic mechanism of RNAs containing nucleotide repeat expansions. Hum Genet. 2017 09; 136(9):1247-1263.
Score: 0.014
-
The roles of RNA processing in translating genotype to phenotype. Nat Rev Mol Cell Biol. 2017 02; 18(2):102-114.
Score: 0.014
-
Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1. Sci Rep. 2016 10 19; 6:35550.
Score: 0.014
-
Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements. Mol Cell. 2016 04 21; 62(2):155-156.
Score: 0.013
-
Roles for RNA-binding proteins in development and disease. Brain Res. 2016 09 15; 1647:1-8.
Score: 0.013
-
The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. Hum Mol Genet. 2015 Apr 15; 24(8):2360-74.
Score: 0.012
-
Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis. Mol Cell. 2014 Aug 21; 55(4):592-603.
Score: 0.012
-
In Brief: (mis)splicing in disease. J Pathol. 2014 May; 233(1):1-3.
Score: 0.012
-
The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression. Cell Rep. 2014 Jan 30; 6(2):336-45.
Score: 0.011
-
RNA-binding proteins in heart development. Adv Exp Med Biol. 2014; 825:389-429.
Score: 0.011
-
Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron. Nucleic Acids Res. 2014 Feb; 42(3):1893-903.
Score: 0.011
-
Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13570-5.
Score: 0.011
-
Antisense oligonucleotides: rising stars in eliminating RNA toxicity in myotonic dystrophy. Hum Gene Ther. 2013 May; 24(5):499-507.
Score: 0.011
-
Pre-mRNA splicing in disease and therapeutics. Trends Mol Med. 2012 Aug; 18(8):472-82.
Score: 0.010
-
RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity. Brain Res. 2012 Jun 26; 1462:100-11.
Score: 0.010
-
Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet. 2011 Sep 16; 12(10):715-29.
Score: 0.010
-
Identification of MBNL1 and MBNL3 domains required for splicing activation and repression. Nucleic Acids Res. 2011 Apr; 39(7):2769-80.
Score: 0.009
-
CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Hum Mol Genet. 2010 Sep 15; 19(18):3614-22.
Score: 0.009
-
Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15; 19(6):1066-75.
Score: 0.009
-
The pathobiology of splicing. J Pathol. 2010 Jan; 220(2):152-63.
Score: 0.009
-
Pathogenic mechanisms of myotonic dystrophy. Biochem Soc Trans. 2009 Dec; 37(Pt 6):1281-6.
Score: 0.009
-
PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest. 2009 Dec; 119(12):3797-806.
Score: 0.009
-
Chemical reversal of the RNA gain of function in myotonic dystrophy. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18433-4.
Score: 0.009
-
Molecular biology. Neutralizing toxic RNA. Science. 2009 Jul 17; 325(5938):272-3.
Score: 0.008
-
CUGBP2 directly interacts with U2 17S snRNP components and promotes U2 snRNA binding to cardiac troponin T pre-mRNA. Nucleic Acids Res. 2009 Jul; 37(13):4275-86.
Score: 0.008
-
Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation. Mol Cell. 2007 Oct 12; 28(1):68-78.
Score: 0.007
-
Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet. 2007 Oct; 8(10):749-61.
Score: 0.007
-
Alternative splicing in disease. Adv Exp Med Biol. 2007; 623:212-23.
Score: 0.007
-
Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. J Am Acad Child Adolesc Psychiatry. 2006 Nov; 45(11):1284-1293.
Score: 0.007
-
A reversal of misfortune for myotonic dystrophy? N Engl J Med. 2006 Oct 26; 355(17):1825-7.
Score: 0.007
-
Minigene reporter for identification and analysis of cis elements and trans factors affecting pre-mRNA splicing. Biotechniques. 2006 Aug; 41(2):177-81.
Score: 0.007
-
Misregulation of alternative splicing causes pathogenesis in myotonic dystrophy. Prog Mol Subcell Biol. 2006; 44:133-59.
Score: 0.007
-
Use of minigene systems to dissect alternative splicing elements. Methods. 2005 Dec; 37(4):331-40.
Score: 0.006
-
Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy. J Cell Sci. 2005 Jul 01; 118(Pt 13):2923-33.
Score: 0.006
-
Identification of CELF splicing activation and repression domains in vivo. Nucleic Acids Res. 2005; 33(9):2769-80.
Score: 0.006
-
Identification of putative new splicing targets for ETR-3 using sequences identified by systematic evolution of ligands by exponential enrichment. Mol Cell Biol. 2005 Feb; 25(3):879-87.
Score: 0.006
-
Alternative splicing regulation impacts heart development. Cell. 2005 Jan 14; 120(1):1-2.
Score: 0.006
-
Muscleblind proteins regulate alternative splicing. EMBO J. 2004 Aug 04; 23(15):3103-12.
Score: 0.006
-
ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. Nucleic Acids Res. 2004; 32(3):1232-41.
Score: 0.006
-
CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. J Biol Chem. 2004 Apr 23; 279(17):17756-64.
Score: 0.006
-
Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol. 2002 Oct 23; 3(11):reviews0008.
Score: 0.005
-
Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol Cell. 2002 Jul; 10(1):45-53.
Score: 0.005
-
Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell. 2002 Mar; 9(3):649-58.
Score: 0.005
-
Highlights of alternative splicing regulation session: yes, no, maybe--a history of paradigm shifts. Sci STKE. 2001 Oct 23; 2001(105):pe35.
Score: 0.005
-
Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet. 2001 Sep; 29(1):40-7.
Score: 0.005
-
The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol. 2001 Feb; 21(4):1285-96.
Score: 0.005
-
Binding of PurH to a muscle-specific splicing enhancer functionally correlates with exon inclusion in vivo. J Biol Chem. 2000 Jul 07; 275(27):20618-26.
Score: 0.004
-
RNA processing and human disease. Cell Mol Life Sci. 2000 Feb; 57(2):235-49.
Score: 0.004
-
Alu insertion variants alter mRNA splicing. Nucleic Acids Res. 2019 01 10; 47(1):421-431.
Score: 0.004
-
Muscle-specific splicing of a heterologous exon mediated by a single muscle-specific splicing enhancer from the cardiac troponin T gene. Mol Cell Biol. 1998 Aug; 18(8):4519-25.
Score: 0.004
-
Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science. 1998 May 01; 280(5364):737-41.
Score: 0.004
-
The regulation of splice-site selection, and its role in human disease. Am J Hum Genet. 1997 Aug; 61(2):259-66.
Score: 0.004
-
Identification of a new class of exonic splicing enhancers by in vivo selection. Mol Cell Biol. 1997 Apr; 17(4):2143-50.
Score: 0.004
-
The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8.
Score: 0.003
-
A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol. 1995 Sep; 15(9):4898-907.
Score: 0.003
-
Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins. Genome Res. 2015 Jun; 25(6):858-71.
Score: 0.003
-
Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell. 2015 Mar 12; 160(6):1087-98.
Score: 0.003
-
Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. Nat Commun. 2014 Nov 20; 5:5274.
Score: 0.003
-
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol. 1993 Jun; 13(6):3660-74.
Score: 0.003
-
In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron. J Biol Chem. 1992 Mar 15; 267(8):5330-8.
Score: 0.003
-
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3665-70.
Score: 0.002
-
Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats. Exp Neurol. 2008 Apr; 210(2):467-78.
Score: 0.002
-
MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Hum Mol Genet. 2006 Jul 01; 15(13):2138-45.
Score: 0.002
-
Insulin receptor splicing alteration in myotonic dystrophy type 2. Am J Hum Genet. 2004 Jun; 74(6):1309-13.
Score: 0.001
-
Myotonic dystrophy: discussion of molecular basis. Adv Exp Med Biol. 2002; 516:27-45.
Score: 0.001
-
Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. J Biol Chem. 1999 Apr 16; 274(16):10951-62.
Score: 0.001
-
A short sequence within two purine-rich enhancers determines 5' splice site specificity. Mol Cell Biol. 1998 Jan; 18(1):343-52.
Score: 0.001
-
A 32-nucleotide exon-splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon. Mol Cell Biol. 1995 Aug; 15(8):3979-88.
Score: 0.001