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This is a "connection" page, showing publications co-authored by BERT O'MALLEY and DAVID LONARD.
BERT O'MALLEY
Connection Strength
11.616
DAVID LONARD
  1. Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer. Clin Cancer Res. 2016 Nov 15; 22(22):5403-5407.
    View in: PubMed
    Score: 0.533
  2. Bufalin is a steroid receptor coactivator inhibitor-response. Cancer Res. 2015 Mar 15; 75(6):1157.
    View in: PubMed
    Score: 0.479
  3. Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol. 2012 Oct; 8(10):598-604.
    View in: PubMed
    Score: 0.398
  4. Minireview: the SRC family of coactivators: an entr?e to understanding a subset of polygenic diseases? Mol Endocrinol. 2010 Feb; 24(2):279-85.
    View in: PubMed
    Score: 0.330
  5. Emerging roles of the ubiquitin proteasome system in nuclear hormone receptor signaling. Prog Mol Biol Transl Sci. 2009; 87:117-35.
    View in: PubMed
    Score: 0.329
  6. Gene transcription: two worlds merged. Nature. 2008 Apr 24; 452(7190):946-7.
    View in: PubMed
    Score: 0.298
  7. SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells? Sci Signal. 2008 Apr 01; 1(13):pe16.
    View in: PubMed
    Score: 0.296
  8. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell. 2007 Sep 07; 27(5):691-700.
    View in: PubMed
    Score: 0.285
  9. Nuclear receptor coregulators and human disease. Endocr Rev. 2007 Aug; 28(5):575-87.
    View in: PubMed
    Score: 0.281
  10. The expanding cosmos of nuclear receptor coactivators. Cell. 2006 May 05; 125(3):411-4.
    View in: PubMed
    Score: 0.260
  11. CRISPR-Cas9 engineering of human T regulatory cells - Design and optimization of a manufacturing process. Mol Immunol. 2025 Aug; 184:13-21.
    View in: PubMed
    Score: 0.244
  12. Expanding functional diversity of the coactivators. Trends Biochem Sci. 2005 Mar; 30(3):126-32.
    View in: PubMed
    Score: 0.239
  13. Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress. J Mol Cell Cardiol. 2024 Sep; 194:70-84.
    View in: PubMed
    Score: 0.229
  14. Steroid receptor coactivators in Treg and Th17 cell biology and function. Front Immunol. 2024; 15:1389041.
    View in: PubMed
    Score: 0.225
  15. Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol Cell Biol. 2004 Jan; 24(1):14-24.
    View in: PubMed
    Score: 0.221
  16. Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2221707120.
    View in: PubMed
    Score: 0.212
  17. Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion. bioRxiv. 2023 Mar 29.
    View in: PubMed
    Score: 0.209
  18. Enhancer-promoter entanglement explains their transcriptional interdependence. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2216436120.
    View in: PubMed
    Score: 0.207
  19. Steroid receptor coactivators - their role in immunity. Front Immunol. 2022; 13:1079011.
    View in: PubMed
    Score: 0.205
  20. A steroid receptor coactivator small molecule "stimulator" attenuates post-stroke ischemic brain injury. Front Mol Neurosci. 2022; 15:1055295.
    View in: PubMed
    Score: 0.205
  21. Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Breast Cancer Res. 2022 10 31; 24(1):73.
    View in: PubMed
    Score: 0.204
  22. Spatial definition of the human progesterone receptor-B transcriptional complex. iScience. 2022 Nov 18; 25(11):105321.
    View in: PubMed
    Score: 0.203
  23. Reply to: Target expression is a relevant factor in synthetic lethal screens. Commun Biol. 2022 08 19; 5(1):836.
    View in: PubMed
    Score: 0.201
  24. Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism. Cell Rep. 2022 03 08; 38(10):110491.
    View in: PubMed
    Score: 0.195
  25. Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 08 13; 28(10):657-670.
    View in: PubMed
    Score: 0.187
  26. A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021 03 25; 4(1):399.
    View in: PubMed
    Score: 0.182
  27. Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3).
    View in: PubMed
    Score: 0.181
  28. Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441.
    View in: PubMed
    Score: 0.181
  29. Drug Combination in Cancer Treatment-From Cocktails to Conjugated Combinations. Cancers (Basel). 2021 Feb 07; 13(4).
    View in: PubMed
    Score: 0.181
  30. Emerging roles of steroid receptor coactivators in stromal cell responses. J Endocrinol. 2021 02; 248(2):R41-R50.
    View in: PubMed
    Score: 0.180
  31. XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nat Commun. 2020 12 04; 11(1):6215.
    View in: PubMed
    Score: 0.178
  32. A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31353-31364.
    View in: PubMed
    Score: 0.178
  33. The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell. 2000 Jun; 5(6):939-48.
    View in: PubMed
    Score: 0.172
  34. Author Correction: Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2020 Mar 05; 10(1):4463.
    View in: PubMed
    Score: 0.169
  35. Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2019 10 22; 9(1):15099.
    View in: PubMed
    Score: 0.165
  36. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7.
    View in: PubMed
    Score: 0.149
  37. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304.
    View in: PubMed
    Score: 0.140
  38. The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets. Horm Cancer. 2016 08; 7(4):229-35.
    View in: PubMed
    Score: 0.130
  39. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75.
    View in: PubMed
    Score: 0.128
  40. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10; 28(2):240-52.
    View in: PubMed
    Score: 0.123
  41. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116.
    View in: PubMed
    Score: 0.120
  42. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. PLoS One. 2014; 9(4):e95243.
    View in: PubMed
    Score: 0.113
  43. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405.
    View in: PubMed
    Score: 0.111
  44. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517.
    View in: PubMed
    Score: 0.110
  45. Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med. 2014; 65:279-92.
    View in: PubMed
    Score: 0.108
  46. Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25; 51(2):185-99.
    View in: PubMed
    Score: 0.107
  47. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87.
    View in: PubMed
    Score: 0.104
  48. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May; 122(5):1869-80.
    View in: PubMed
    Score: 0.098
  49. Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. Mol Endocrinol. 2011 Dec; 25(12):2041-53.
    View in: PubMed
    Score: 0.095
  50. Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene. 2011 Oct 20; 30(42):4350-64.
    View in: PubMed
    Score: 0.092
  51. Modulation of steroid hormone receptor activity. Prog Brain Res. 2010; 181:153-76.
    View in: PubMed
    Score: 0.084
  52. Estrogen receptor-a: molecular mechanisms and interactions with the ubiquitin proteasome system. Horm Mol Biol Clin Investig. 2010 Jan; 1(1):1-9.
    View in: PubMed
    Score: 0.084
  53. Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends Endocrinol Metab. 2009 Jan; 20(1):8-15.
    View in: PubMed
    Score: 0.077
  54. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008 Feb 29; 29(4):465-76.
    View in: PubMed
    Score: 0.074
  55. A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008 Feb; 22(2):344-60.
    View in: PubMed
    Score: 0.072
  56. Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell. 2007 Jun 22; 26(6):831-42.
    View in: PubMed
    Score: 0.070
  57. SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell. 2007 Jun 15; 129(6):1125-40.
    View in: PubMed
    Score: 0.070
  58. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006 Jan 27; 124(2):381-92.
    View in: PubMed
    Score: 0.064
  59. Human Extravillous Trophoblasts Require SRC-2 for Sustained Viability, Migration, and Invasion. Cells. 2025 Jul 04; 14(13).
    View in: PubMed
    Score: 0.061
  60. Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II. J Steroid Biochem Mol Biol. 2005 Mar; 94(4):337-46.
    View in: PubMed
    Score: 0.060
  61. A contemporary understanding of progesterone receptor function. Mech Ageing Dev. 2004 Oct-Nov; 125(10-11):669-78.
    View in: PubMed
    Score: 0.058
  62. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. PLoS One. 2024; 19(4):e0289902.
    View in: PubMed
    Score: 0.056
  63. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 04 11; 67(7):5333-5350.
    View in: PubMed
    Score: 0.056
  64. Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation. FASEB J. 2023 12; 37(12):e23313.
    View in: PubMed
    Score: 0.055
  65. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. Res Sq. 2023 Mar 10.
    View in: PubMed
    Score: 0.052
  66. Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3. Front Reprod Health. 2022; 4:1033581.
    View in: PubMed
    Score: 0.051
  67. Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022.
    View in: PubMed
    Score: 0.045
  68. Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer. Endocr Relat Cancer. 2020 04; 27(4):209-220.
    View in: PubMed
    Score: 0.043
  69. Proteasome-dependent degradation of the human estrogen receptor. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):1858-62.
    View in: PubMed
    Score: 0.039
  70. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol Cell Biol. 1999 Feb; 19(2):1182-9.
    View in: PubMed
    Score: 0.039
  71. SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319.
    View in: PubMed
    Score: 0.039
  72. Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 08; 37(33):4581-4598.
    View in: PubMed
    Score: 0.037
  73. USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells. Nat Commun. 2018 03 28; 9(1):1270.
    View in: PubMed
    Score: 0.037
  74. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5.
    View in: PubMed
    Score: 0.032
  75. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011.
    View in: PubMed
    Score: 0.031
  76. Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6997-7002.
    View in: PubMed
    Score: 0.026
  77. OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem. 2009 Jun 12; 284(24):16135-16145.
    View in: PubMed
    Score: 0.020
  78. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. Mol Endocrinol. 2002 Feb; 16(2):253-70.
    View in: PubMed
    Score: 0.012
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The connection strength for concepts is the sum of the scores for each matching publication.

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