MING HU to Animals
This is a "connection" page, showing publications MING HU has written about Animals.
Connection Strength
1.003
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The role of gut microbial ?-glucuronidase in drug disposition and development. Drug Discov Today. 2022 10; 27(10):103316.
Score: 0.042
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Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo. Arch Toxicol. 2020 11; 94(11):3737-3749.
Score: 0.037
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Flavonoids interference in common protein assays: Effect of position and degree of hydroxyl substitution. Anal Biochem. 2020 05 15; 597:113644.
Score: 0.035
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Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc?am1137) rat with celecoxib. Inflamm Res. 2020 Jan; 69(1):131-137.
Score: 0.035
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Development and validation of a sensitive LC-MS/MS method for simultaneous determination of eight tyrosine kinase inhibitors and its application in mice pharmacokinetic studies. J Pharm Biomed Anal. 2018 Jan 30; 148:65-72.
Score: 0.030
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Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. J Pharm Biomed Anal. 2018 Jan 30; 148:42-50.
Score: 0.029
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Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway. Mol Nutr Food Res. 2016 09; 60(9):1967-83.
Score: 0.027
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Determination of 7a-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 01; 1025:76-82.
Score: 0.027
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Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15; 1015-1016:34-41.
Score: 0.027
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Factors Influencing Oral Bioavailability of Thai Mango Seed Kernel Extract and Its Key Phenolic Principles. Molecules. 2015 Nov 30; 20(12):21254-73.
Score: 0.026
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Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Pharm Res. 2016 Mar; 33(3):590-602.
Score: 0.026
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Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 01; 1002:13-8.
Score: 0.026
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Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15; 1001:202-11.
Score: 0.026
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Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem. 2012 Dec; 12(10):1264-80.
Score: 0.021
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Effects of estrogen and estrus cycle on pharmacokinetics, absorption, and disposition of genistein in female Sprague-Dawley rats. J Agric Food Chem. 2012 Aug 15; 60(32):7949-56.
Score: 0.021
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Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genistein. Drug Metab Dispos. 2012 Oct; 40(10):1883-93.
Score: 0.021
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Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora. Drug Metab Dispos. 2012 Aug; 40(8):1538-44.
Score: 0.021
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Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012 May; 44(2):192-208.
Score: 0.020
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Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis. Curr Drug Metab. 2011 Nov; 12(9):900-16.
Score: 0.020
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Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms. Drug Metab Dispos. 2011 Oct; 39(10):1866-72.
Score: 0.019
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First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J Pharm Sci. 2011 Sep; 100(9):3655-81.
Score: 0.019
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Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. Molecules. 2011 Feb 01; 16(2):1336-48.
Score: 0.019
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Validated LC-MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: application to pharmacokinetic and disposition studies. J Pharm Biomed Anal. 2011 May 15; 55(2):288-93.
Score: 0.019
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The pharmacokinetics of raloxifene and its interaction with apigenin in rat. Molecules. 2010 Nov 18; 15(11):8478-87.
Score: 0.019
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Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine. AAPS J. 2010 Dec; 12(4):525-36.
Score: 0.018
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Bioavailability challenges associated with development of anti-cancer phenolics. Mini Rev Med Chem. 2010 Jun; 10(6):550-67.
Score: 0.018
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Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. J Pharm Biomed Anal. 2010 Sep 21; 53(1):81-9.
Score: 0.018
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Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC-MS/MS method. J Pharm Biomed Anal. 2010 Apr 06; 51(5):1120-7.
Score: 0.017
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Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides. Mol Pharm. 2009 Nov-Dec; 6(6):1703-15.
Score: 0.017
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Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities. J Pharmacol Exp Ther. 2009 Jun; 329(3):1023-31.
Score: 0.016
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Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharm Res. 2008 Sep; 25(9):2190-9.
Score: 0.016
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Commentary: bioavailability of flavonoids and polyphenols: call to arms. Mol Pharm. 2007 Nov-Dec; 4(6):803-6.
Score: 0.015
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Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm. 2007 Nov-Dec; 4(6):883-94.
Score: 0.015
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Natural polyphenol disposition via coupled metabolic pathways. Expert Opin Drug Metab Toxicol. 2007 Jun; 3(3):389-406.
Score: 0.015
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Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine. Pharm Res. 2006 Dec; 23(12):2768-80.
Score: 0.014
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Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties. Drug Metab Dispos. 2006 Nov; 34(11):1837-48.
Score: 0.014
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Disposition of flavonoids via recycling: comparison of intestinal versus hepatic disposition. Drug Metab Dispos. 2005 Dec; 33(12):1777-84.
Score: 0.013
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Disposition of formononetin via enteric recycling: metabolism and excretion in mouse intestinal perfusion and Caco-2 cell models. Mol Pharm. 2005 Jul-Aug; 2(4):319-28.
Score: 0.013
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Species- and disposition model-dependent metabolism of raloxifene in gut and liver: role of UGT1A10. Drug Metab Dispos. 2005 Jun; 33(6):785-94.
Score: 0.013
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Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates. J Pharmacol Exp Ther. 2004 Sep; 310(3):1103-13.
Score: 0.012
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Enteric disposition and recycling of flavonoids and ginkgo flavonoids. J Altern Complement Med. 2003 Oct; 9(5):631-40.
Score: 0.011
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Functional and molecular characterization of rat intestinal prolidase. Pediatr Res. 2003 Jun; 53(6):905-14.
Score: 0.011
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Metabolism of flavonoids via enteric recycling: role of intestinal disposition. J Pharmacol Exp Ther. 2003 Mar; 304(3):1228-35.
Score: 0.011
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Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab Dispos. 2002 Apr; 30(4):370-7.
Score: 0.010
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Age-and Region-Dependent Disposition of Raloxifene in Rats. Pharm Res. 2021 Aug; 38(8):1357-1367.
Score: 0.010
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P-glycoprotein and bioavailability-implication of polymorphism. Clin Chem Lab Med. 2000 Sep; 38(9):877-81.
Score: 0.009
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Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model. J Pharm Sci. 1998 Jul; 87(7):886-90.
Score: 0.008
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Comparison of the transport characteristics of D- and L-methionine in a human intestinal epithelial model (Caco-2) and in a perfused rat intestinal model. Pharm Res. 1994 Dec; 11(12):1771-6.
Score: 0.006
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A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. Mol Pharm. 2012 Nov 05; 9(11):3246-58.
Score: 0.005
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Pharmacokinetics and renal disposition of polymyxin B in an animal model. Antimicrob Agents Chemother. 2012 Nov; 56(11):5724-7.
Score: 0.005
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CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice. Br J Pharmacol. 2012 Aug; 166(7):2176-87.
Score: 0.005
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Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design. Antimicrob Agents Chemother. 2012 Sep; 56(9):4625-9.
Score: 0.005
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Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences. J Agric Food Chem. 2012 Mar 28; 60(12):3223-33.
Score: 0.005
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Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine. Xenobiotica. 2012 Jun; 42(6):518-25.
Score: 0.005
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Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. Mol Carcinog. 2013 Jan; 52(1):49-56.
Score: 0.005
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Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison. J Pharm Pharmacol. 2011 Jul; 63(7):967-70.
Score: 0.005
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Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. J Pharm Sci. 2011 Nov; 100(11):5007-17.
Score: 0.005
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Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide. J Pharm Biomed Anal. 2011 Apr 05; 54(5):1157-62.
Score: 0.005
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Species and gender differences affect the metabolism of emodin via glucuronidation. AAPS J. 2010 Sep; 12(3):424-36.
Score: 0.004
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Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa. Pharm Res. 1989 Jan; 6(1):66-70.
Score: 0.004
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Passive and carrier-mediated intestinal absorption components of captopril. J Pharm Sci. 1988 Dec; 77(12):1007-11.
Score: 0.004
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In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts. J Agric Food Chem. 2008 Jul 23; 56(14):5550-7.
Score: 0.004
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Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach. J Theor Biol. 1988 Mar 07; 131(1):107-14.
Score: 0.004
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Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression. Eur J Pharm Sci. 2000 Nov; 12(1):63-8.
Score: 0.002
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Utilization of peptide carrier system to improve intestinal absorption: targeting prolidase as a prodrug-converting enzyme. J Pharm Sci. 1992 Feb; 81(2):113-6.
Score: 0.001