MING HU to Humans
This is a "connection" page, showing publications MING HU has written about Humans.
Connection Strength
0.478
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Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo. Arch Toxicol. 2020 11; 94(11):3737-3749.
Score: 0.018
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LC-MS/MS quantification of sulfotransferases is better than conventional immunogenic methods in determining human liver SULT activities: implication in precision medicine. Sci Rep. 2017 06 20; 7(1):3858.
Score: 0.015
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Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway. Mol Nutr Food Res. 2016 09; 60(9):1967-83.
Score: 0.014
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Factors Influencing Oral Bioavailability of Thai Mango Seed Kernel Extract and Its Key Phenolic Principles. Molecules. 2015 Nov 30; 20(12):21254-73.
Score: 0.013
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Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Pharm Res. 2016 Mar; 33(3):590-602.
Score: 0.013
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Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem. 2012 Dec; 12(10):1264-80.
Score: 0.011
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A new strategy to rapidly evaluate kinetics of glucuronide efflux by breast cancer resistance protein (BCRP/ABCG2). Pharm Res. 2012 Nov; 29(11):3199-208.
Score: 0.010
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Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genistein. Drug Metab Dispos. 2012 Oct; 40(10):1883-93.
Score: 0.010
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Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches. Pharm Res. 2012 Jun; 29(6):1544-61.
Score: 0.010
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Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora. Drug Metab Dispos. 2012 Aug; 40(8):1538-44.
Score: 0.010
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SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies. Mol Pharm. 2012 Apr 02; 9(4):862-73.
Score: 0.010
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Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012 May; 44(2):192-208.
Score: 0.010
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UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. Drug Metab Dispos. 2012 Feb; 40(2):336-45.
Score: 0.010
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Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis. Curr Drug Metab. 2011 Nov; 12(9):900-16.
Score: 0.010
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Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1. Mol Pharm. 2011 Dec 05; 8(6):2379-89.
Score: 0.010
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Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms. Drug Metab Dispos. 2011 Oct; 39(10):1866-72.
Score: 0.010
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Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids. J Agric Food Chem. 2011 Jul 13; 59(13):7452-64.
Score: 0.010
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First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J Pharm Sci. 2011 Sep; 100(9):3655-81.
Score: 0.010
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Regioselective glucuronidation of flavonols by six human UGT1A isoforms. Pharm Res. 2011 Aug; 28(8):1905-18.
Score: 0.010
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Validated LC-MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: application to pharmacokinetic and disposition studies. J Pharm Biomed Anal. 2011 May 15; 55(2):288-93.
Score: 0.009
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Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model. J Pharmacol Exp Ther. 2011 Feb; 336(2):403-13.
Score: 0.009
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Highly variable contents of phenolics in St. John's Wort products affect their transport in the human intestinal Caco-2 cell model: pharmaceutical and biopharmaceutical rationale for product standardization. J Agric Food Chem. 2010 Jun 09; 58(11):6650-9.
Score: 0.009
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Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol Pharm. 2010 Jun 07; 7(3):664-79.
Score: 0.009
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Bioavailability challenges associated with development of anti-cancer phenolics. Mini Rev Med Chem. 2010 Jun; 10(6):550-67.
Score: 0.009
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Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. Pharm Res. 2010 Aug; 27(8):1568-83.
Score: 0.009
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Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC-MS/MS method. J Pharm Biomed Anal. 2010 Apr 06; 51(5):1120-7.
Score: 0.009
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Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones. Mol Pharm. 2009 Sep-Oct; 6(5):1466-82.
Score: 0.009
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Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS. J Pharm Biomed Anal. 2009 Jul 12; 49(5):1226-32.
Score: 0.008
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Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharm Res. 2008 Sep; 25(9):2190-9.
Score: 0.008
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Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein. J Altern Complement Med. 2008 Apr; 14(3):287-97.
Score: 0.008
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Commentary: bioavailability of flavonoids and polyphenols: call to arms. Mol Pharm. 2007 Nov-Dec; 4(6):803-6.
Score: 0.007
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Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm. 2007 Nov-Dec; 4(6):883-94.
Score: 0.007
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Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA. Mol Pharm. 2007 Nov-Dec; 4(6):873-82.
Score: 0.007
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Natural polyphenol disposition via coupled metabolic pathways. Expert Opin Drug Metab Toxicol. 2007 Jun; 3(3):389-406.
Score: 0.007
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Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine. Pharm Res. 2006 Dec; 23(12):2768-80.
Score: 0.007
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Coupling of conjugating enzymes and efflux transporters: impact on bioavailability and drug interactions. Curr Drug Metab. 2005 Oct; 6(5):455-68.
Score: 0.006
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Disposition of formononetin via enteric recycling: metabolism and excretion in mouse intestinal perfusion and Caco-2 cell models. Mol Pharm. 2005 Jul-Aug; 2(4):319-28.
Score: 0.006
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Species- and disposition model-dependent metabolism of raloxifene in gut and liver: role of UGT1A10. Drug Metab Dispos. 2005 Jun; 33(6):785-94.
Score: 0.006
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Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products. J Altern Complement Med. 2004 Dec; 10(6):1053-60.
Score: 0.006
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Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model. Cancer Chemother Pharmacol. 2005 Feb; 55(2):159-69.
Score: 0.006
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Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates. J Pharmacol Exp Ther. 2004 Sep; 310(3):1103-13.
Score: 0.006
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Nucleobase- and p-glycoprotein-mediated transport of AG337 in a Caco-2 cell culture model. Mol Pharm. 2004 May-Jun; 1(3):194-200.
Score: 0.006
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Disposition mechanisms of raloxifene in the human intestinal Caco-2 model. J Pharmacol Exp Ther. 2004 Jul; 310(1):376-85.
Score: 0.006
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Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model. J Pharmacol Exp Ther. 2003 Oct; 307(1):314-21.
Score: 0.006
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Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. Drug Metab Dispos. 2003 Jul; 31(7):924-31.
Score: 0.006
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Metabolism of flavonoids via enteric recycling: role of intestinal disposition. J Pharmacol Exp Ther. 2003 Mar; 304(3):1228-35.
Score: 0.005
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Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab Dispos. 2002 Apr; 30(4):370-7.
Score: 0.005
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P-glycoprotein and bioavailability-implication of polymorphism. Clin Chem Lab Med. 2000 Sep; 38(9):877-81.
Score: 0.005
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Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase. Pharm Res. 1999 Sep; 16(9):1352-9.
Score: 0.004
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Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4. Pharm Res. 1996 Nov; 13(11):1635-41.
Score: 0.003
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Uptake characteristics of loracarbef and cephalexin in the Caco-2 cell culture model: effects of the proton gradient and possible presence of a distinctive second component. J Pharm Sci. 1996 Jul; 85(7):767-72.
Score: 0.003
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Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients. Mol Cancer Ther. 2015 Dec; 14(12):2874-86.
Score: 0.003
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Mechanisms of transport of quinapril in Caco-2 cell monolayers: comparison with cephalexin. Pharm Res. 1995 Aug; 12(8):1120-5.
Score: 0.003
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Peptide transporter function and prolidase activities in Caco-2 cells: a lack of coordinated expression. J Drug Target. 1995; 3(4):291-300.
Score: 0.003
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Mechanism and kinetics of transcellular transport of a new beta-lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2). Pharm Res. 1994 Oct; 11(10):1405-13.
Score: 0.003
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Mechanisms and kinetics of uptake and efflux of L-methionine in an intestinal epithelial model (Caco-2). J Nutr. 1994 Oct; 124(10):1907-16.
Score: 0.003
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The Caco-2 cell monolayers as an intestinal metabolism model: metabolism of dipeptide Phe-Pro. J Drug Target. 1994; 2(1):79-89.
Score: 0.003
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Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system. J Pharm Sci. 1993 Aug; 82(8):829-33.
Score: 0.003
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A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. Mol Pharm. 2012 Nov 05; 9(11):3246-58.
Score: 0.003
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Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine. Biochim Biophys Acta. 1992 Jun 29; 1135(3):233-44.
Score: 0.003
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Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design. Antimicrob Agents Chemother. 2012 Sep; 56(9):4625-9.
Score: 0.003
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Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes. Xenobiotica. 2012 Aug; 42(8):808-20.
Score: 0.003
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Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison. J Pharm Pharmacol. 2011 Jul; 63(7):967-70.
Score: 0.002
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Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. J Pharm Sci. 2011 Nov; 100(11):5007-17.
Score: 0.002
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Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharm Res. 1990 Dec; 7(12):1313-9.
Score: 0.002
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Species and gender differences affect the metabolism of emodin via glucuronidation. AAPS J. 2010 Sep; 12(3):424-36.
Score: 0.002
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Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Prostate. 2009 Apr 01; 69(5):494-504.
Score: 0.002
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Kinetic characterization of secretory transport of a new ciprofloxacin derivative (CNV97100) across Caco-2 cell monolayers. J Pharm Sci. 2002 Dec; 91(12):2511-9.
Score: 0.001
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Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression. Eur J Pharm Sci. 2000 Nov; 12(1):63-8.
Score: 0.001
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Lispro insulin: adsorption and stability in selected intravenous devices. Diabetes Educ. 1999 Mar-Apr; 25(2):237-45.
Score: 0.001