"Crigler-Najjar Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.
| Descriptor ID |
D003414
|
| MeSH Number(s) |
C16.320.565.300.281 C18.452.648.300.281
|
| Concept/Terms |
Crigler-Najjar Syndrome- Crigler-Najjar Syndrome
- Crigler Najjar Syndrome, Type 1
- Crigler-Najar Syndrome
- Crigler Najar Syndrome
- Familial Nonhemolytic Unconjugated Hyperbilirubinemia
- Hereditary Unconjugated Hyperbilirubinemia
- Crigler Najjar Syndrome
- Crigler-Najjar Syndrome, Type I
- Crigler Najjar Syndrome, Type I
|
Below are MeSH descriptors whose meaning is more general than "Crigler-Najjar Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Crigler-Najjar Syndrome".
This graph shows the total number of publications written about "Crigler-Najjar Syndrome" by people in this website by year, and whether "Crigler-Najjar Syndrome" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Crigler-Najjar Syndrome" by people in Profiles.
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Correction of hyperbilirubinemia in gunn rats by surgical delivery of low doses of helper-dependent adenoviral vectors. Hum Gene Ther Methods. 2014 Jun; 25(3):181-6.
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Improved efficacy and reduced toxicity by ultrasound-guided intrahepatic injections of helper-dependent adenoviral vector in Gunn rats. Hum Gene Ther Methods. 2013 Oct; 24(5):321-7.
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Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectors. Hum Gene Ther. 2011 Apr; 22(4):483-8.
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A novel intronic mutation results in the use of a cryptic splice acceptor site within the coding region of UGT1A1, causing Crigler-Najjar syndrome type 1. Mol Genet Metab. 2002 Feb; 75(2):134-42.