"GABA Modulators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
| Descriptor ID |
D018757
|
| MeSH Number(s) |
D27.505.519.625.240.500 D27.505.696.577.240.500
|
| Concept/Terms |
GABA Modulators- GABA Modulators
- Modulators, GABA
- GABAergic Modulators
- Modulators, GABAergic
- gamma-Aminobutyric Acid Modulators
- Acid Modulators, gamma-Aminobutyric
- Modulators, gamma-Aminobutyric Acid
- gamma Aminobutyric Acid Modulators
|
Below are MeSH descriptors whose meaning is more general than "GABA Modulators".
Below are MeSH descriptors whose meaning is more specific than "GABA Modulators".
This graph shows the total number of publications written about "GABA Modulators" by people in this website by year, and whether "GABA Modulators" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "GABA Modulators" by people in Profiles.
-
Outcomes in Children Treated with Pentobarbital Infusion for Refractory and Super-Refractory Status Epilepticus. Neurocrit Care. 2018 10; 29(2):171-179.
-
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. Brain Res. 2018 03 01; 1682:14-23.
-
Phenotype of GABA-transaminase deficiency. Neurology. 2017 May 16; 88(20):1919-1924.
-
In vivo measurement of GABA transmission in healthy subjects and schizophrenia patients. Am J Psychiatry. 2015 Nov 01; 172(11):1148-59.
-
[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels. PLoS One. 2012; 7(2):e32443.
-
Benzodiazepine inhibits hypothalamic presympathetic neurons by potentiation of GABAergic synaptic input. Neuropharmacology. 2007 Feb; 52(2):467-75.
-
Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase. Pharm Res. 1999 Sep; 16(9):1352-9.
-
Antagonism of soman-induced convulsions by midazolam, diazepam and scopolamine. Drug Chem Toxicol. 1997 Aug; 20(3):115-31.
-
Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine. Brain Res. 1983 Jan 03; 258(1):159-64.