"Superantigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
| Descriptor ID |
D018089
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| MeSH Number(s) |
D23.050.820
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Superantigens".
Below are MeSH descriptors whose meaning is more specific than "Superantigens".
This graph shows the total number of publications written about "Superantigens" by people in this website by year, and whether "Superantigens" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Superantigens" by people in Profiles.
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Epidemiology of toxic shock syndrome toxin-1 harboring Staphylococcus aureus obtained from clinical samples in Iran: A Systematic Review and Meta-analysis. Ann Ig. 2018 Sep-Oct; 30(5):391-400.
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Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis. J Parasitol. 2017 10; 103(5):579-583.
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Identification and Characterization of the Trypanosoma cruzi B-cell Superantigen Tc24. Am J Trop Med Hyg. 2016 Jan; 94(1):114-121.
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Clostridium difficile lacks detectable superantigen activity. FEMS Immunol Med Microbiol. 2006 Jul; 47(2):275-7.
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Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 01; 173(1):297-306.
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Reactivity of resident immunocytes in normal and prepsoriatic skin using an ex vivo skin-explant model system. Arch Pathol Lab Med. 2003 Mar; 127(3):289-96.
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Cutaneous T-cell lymphomas and bacterial superantigens. Blood. 1997 Jul 01; 90(1):472-3.
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Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion. Blood. 1997 Jan 01; 89(1):32-40.
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Detection of retroviral superantigen and products of the envelope gene from endogenous mouse mammary tumor virus in B cells from BALB/c mice. Cell Immunol. 1995 Jul; 163(2):191-7.
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Staphylococcal toxins bind to different sites on HLA-DR. J Immunol. 1991 Dec 01; 147(11):3876-81.