"Buthionine Sulfoximine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
| Descriptor ID |
D019328
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| MeSH Number(s) |
D02.886.030.676.620.125 D12.125.166.676.620.125
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Buthionine Sulfoximine".
Below are MeSH descriptors whose meaning is more specific than "Buthionine Sulfoximine".
This graph shows the total number of publications written about "Buthionine Sulfoximine" by people in this website by year, and whether "Buthionine Sulfoximine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Buthionine Sulfoximine" by people in Profiles.
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Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice. Clin Exp Hypertens. 2021 Feb 17; 43(2):175-180.
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Oxidative stress impairs cGMP-dependent protein kinase activation and vasodilator-stimulated phosphoprotein serine-phosphorylation. Clin Exp Hypertens. 2019; 41(1):5-13.
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Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. Sci Rep. 2016 06 10; 6:27458.
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Protective Effect of Tempol on Buthionine Sulfoximine-Induced Mitochondrial Impairment in Hippocampal Derived HT22 Cells. Oxid Med Cell Longev. 2016; 2016:5059043.
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Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer. Antioxid Redox Signal. 2015 Jul 01; 23(1):15-29.
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Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B. Clin Exp Hypertens. 2014; 36(6):367-73.
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Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells. BMC Cancer. 2013 Oct 26; 13:500.
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Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats. J Nutr. 2013 Jun; 143(6):835-42.
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Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by ?-phenethyl isothiocyanate: mechanisms for anti-leukemia activity. Antioxid Redox Signal. 2011 Dec 15; 15(12):2911-21.
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Potential contribution of oxidative stress and inflammation to anxiety and hypertension. Brain Res. 2011 Aug 02; 1404:63-71.