"Podophyllotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
| Descriptor ID |
D011034
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| MeSH Number(s) |
D02.455.426.559.389.140.450.777 D02.455.426.559.847.638.960.675 D04.615.638.960.675
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Podophyllotoxin".
Below are MeSH descriptors whose meaning is more specific than "Podophyllotoxin".
This graph shows the total number of publications written about "Podophyllotoxin" by people in this website by year, and whether "Podophyllotoxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Podophyllotoxin" by people in Profiles.
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Polygenic Risk and Chemotherapy-Related Subsequent Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study and St Jude Lifetime Cohort Study Report. J Clin Oncol. 2023 09 20; 41(27):4381-4393.
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Outcomes of autologous stem cell transplantation in Waldenstr?m's macroglobulinemia. Ann Hematol. 2019 Sep; 98(9):2233-2235.
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Allogeneic Transplantation after Myeloablative Rituximab/BEAM ? Bortezomib for Patients with Relapsed/Refractory Lymphoid Malignancies: 5-Year Follow-Up Results. Biol Blood Marrow Transplant. 2019 07; 25(7):1347-1354.
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GSH-Activated NIR Fluorescent Prodrug for Podophyllotoxin Delivery. ACS Appl Mater Interfaces. 2017 Sep 06; 9(35):29496-29504.
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Pretransplant functional imaging and outcome in pediatric patients with relapsed/refractory Hodgkin lymphoma undergoing autologous transplantation. Pediatr Blood Cancer. 2018 Jan; 65(1).
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Induction of apoptotic DNA fragmentation mediated by mitochondrial pathway with caspase-3-dependent BID cleavage in human gastric cancer cells by a new nitroxyl spin-labeled derivative of podophyllotoxin. Biomed Pharmacother. 2017 Jun; 90:131-138.
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Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma. Leuk Lymphoma. 2014 Aug; 55(8):1876-83.
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Reengineered epipodophyllotoxin. Chem Commun (Camb). 2012 Oct 28; 48(84):10416-8.
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Effects of epidermal growth factor receptor and insulin-like growth factor 1 receptor inhibition on proliferation and intracellular signaling in cutaneous SCCHN: potential for dual inhibition as a therapeutic modality. Head Neck. 2013 Jan; 35(1):86-93.
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Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma. Haematologica. 2011 Jun; 96(6):871-80.