Luteinizing Hormone, beta Subunit
"Luteinizing Hormone, beta Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.
| Descriptor ID |
D037101
|
| MeSH Number(s) |
D06.472.699.322.576.463.500 D06.472.699.631.525.343.463.500 D12.644.548.691.525.343.463.500
|
| Concept/Terms |
Luteinizing Hormone, beta Subunit- Luteinizing Hormone, beta Subunit
- Lutropin, beta Subunit
- Luteinizing Hormone, beta Chain
- Luteinizing Hormone, beta Polypeptide Chain
- Lutropin-beta
- Lutropin beta
- ICSH, beta Subunit
- LH-beta
- LH beta
- LH, beta Subunit
|
Below are MeSH descriptors whose meaning is more general than "Luteinizing Hormone, beta Subunit".
- Chemicals and Drugs [D]
- Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
- Peptide Hormones [D06.472.699]
- Gonadotropins [D06.472.699.322]
- Gonadotropins, Pituitary [D06.472.699.322.576]
- Luteinizing Hormone [D06.472.699.322.576.463]
- Luteinizing Hormone, beta Subunit [D06.472.699.322.576.463.500]
- Pituitary Hormones [D06.472.699.631]
- Pituitary Hormones, Anterior [D06.472.699.631.525]
- Gonadotropins, Pituitary [D06.472.699.631.525.343]
- Luteinizing Hormone [D06.472.699.631.525.343.463]
- Luteinizing Hormone, beta Subunit [D06.472.699.631.525.343.463.500]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Peptide Hormones [D12.644.548]
- Pituitary Hormones [D12.644.548.691]
- Pituitary Hormones, Anterior [D12.644.548.691.525]
- Gonadotropins, Pituitary [D12.644.548.691.525.343]
- Luteinizing Hormone [D12.644.548.691.525.343.463]
- Luteinizing Hormone, beta Subunit [D12.644.548.691.525.343.463.500]
Below are MeSH descriptors whose meaning is more specific than "Luteinizing Hormone, beta Subunit".
This graph shows the total number of publications written about "Luteinizing Hormone, beta Subunit" by people in this website by year, and whether "Luteinizing Hormone, beta Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Luteinizing Hormone, beta Subunit" by people in Profiles.
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NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo. PLoS One. 2013; 8(3):e59058.
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Follicle-stimulating hormone regulates both Sertoli cell and spermatogonial populations in the adult photoinhibited Djungarian hamster testis. Biol Reprod. 2005 May; 72(5):1187-93.
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Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17294-9.
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Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins. Endocrinology. 2003 Oct; 144(10):4492-507.