Glutamate-Cysteine Ligase
"Glutamate-Cysteine Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
| Descriptor ID |
D005721
|
| MeSH Number(s) |
D08.811.464.259.850.400
|
| Concept/Terms |
Glutamate-Cysteine Ligase- Glutamate-Cysteine Ligase
- Glutamate Cysteine Ligase
- Ligase, Glutamate-Cysteine
- gamma-Glutamyl-Cysteine Synthetase
- Synthetase, gamma-Glutamyl-Cysteine
- gamma Glutamyl Cysteine Synthetase
- Glutamylcysteine Synthetase
- Synthetase, Glutamylcysteine
|
Below are MeSH descriptors whose meaning is more general than "Glutamate-Cysteine Ligase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate-Cysteine Ligase".
This graph shows the total number of publications written about "Glutamate-Cysteine Ligase" by people in this website by year, and whether "Glutamate-Cysteine Ligase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1997 | 2 | 0 | 2 |
| 1998 | 2 | 0 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 2 | 1 | 3 |
| 2001 | 1 | 0 | 1 |
| 2002 | 3 | 0 | 3 |
| 2005 | 1 | 1 | 2 |
| 2008 | 0 | 3 | 3 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamate-Cysteine Ligase" by people in Profiles.
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IRE1a determines ferroptosis sensitivity through regulation of glutathione synthesis. Nat Commun. 2024 May 15; 15(1):4114.
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Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis. Cancer Res. 2019 01 01; 79(1):125-132.
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Comparison of PBDE congeners as inducers of oxidative stress in zebrafish. Environ Toxicol Chem. 2015 May; 34(5):1154-60.
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Elevated GSH level increases cadmium resistance through down-regulation of Sp1-dependent expression of the cadmium transporter ZIP8. Mol Pharmacol. 2008 Sep; 74(3):823-33.
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Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1. Mol Pharmacol. 2008 Sep; 74(3):697-704.
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Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. Toxicol Appl Pharmacol. 2008 May 15; 229(1):44-55.
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Glutathione is required for growth and prespore cell differentiation in Dictyostelium. Dev Biol. 2005 Aug 15; 284(2):387-98.
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Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling. J Biol Chem. 2005 Aug 05; 280(31):28230-40.
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Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells. Free Radic Res. 2005 Apr; 39(4):373-81.
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Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity. Toxicol Lett. 2002 Dec 15; 136(2):107-20.