"Semaphorin-3A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.
| Descriptor ID |
D040121
|
| MeSH Number(s) |
D12.644.276.923.374 D12.776.467.923.374 D23.529.923.374
|
| Concept/Terms |
Semaphorin-3A- Semaphorin-3A
- Sem D
- Semaphorin D
- Collapsin-1
- Collapsin 1
- Sema3A
- Semaphorin 3A
- Collapsing Factor
- Collapsin
|
Below are MeSH descriptors whose meaning is more general than "Semaphorin-3A".
Below are MeSH descriptors whose meaning is more specific than "Semaphorin-3A".
This graph shows the total number of publications written about "Semaphorin-3A" by people in this website by year, and whether "Semaphorin-3A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Semaphorin-3A" by people in Profiles.
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Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell. 2007 Jan; 11(1):53-67.
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Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors. Cancer Res. 2005 May 01; 65(9):3664-70.
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Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance. Brain Res Mol Brain Res. 1998 Mar 01; 54(2):219-36.