"Cilastatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
| Descriptor ID |
D015377
|
| MeSH Number(s) |
D02.455.426.392.368.533.200 D10.251.355.325.200
|
| Concept/Terms |
MK 0791- MK 0791
- MK-791
- MK 791
- MK791
- MK0791
Cilastatin Sodium- Cilastatin Sodium
- Sodium, Cilastatin
- Cilastatin Monosodium Salt
- Monosodium Salt, Cilastatin
- Salt, Cilastatin Monosodium
|
Below are MeSH descriptors whose meaning is more general than "Cilastatin".
Below are MeSH descriptors whose meaning is more specific than "Cilastatin".
This graph shows the total number of publications written about "Cilastatin" by people in this website by year, and whether "Cilastatin" was a major or minor topic of these publications.
![]()
To see the data from this visualization as text,
click here.
Below are the most recent publications written about "Cilastatin" by people in Profiles.
-
A randomized non-inferiority study comparing imipenem/cilastatin/relebactam with standard-of-care Gram-negative coverage in cancer patients with febrile neutropenia. J Antimicrob Chemother. 2024 Oct 01; 79(10):2543-2553.
-
How should imipenem-cilastatin be used in the treatment of fever and infection in neutropenic cancer patients? Cancer. 1998 Jun 15; 82(12):2449-58.
-
Nocardiosis in renal transplant recipients undergoing immunosuppression with cyclosporine. Clin Infect Dis. 1993 Apr; 16(4):505-12.
-
Antimicrobial update. Drug Intell Clin Pharm. 1986 Jul-Aug; 20(7-8):583-6.
-
Single-dose pharmacokinetics of imipenem-cilastatin in neonates. Antimicrob Agents Chemother. 1985 Apr; 27(4):511-4.