"Hemoglobin, Sickle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
| Descriptor ID |
D006451
|
| MeSH Number(s) |
D12.776.124.400.463.588 D12.776.422.316.762.426.588
|
| Concept/Terms |
Deoxyhemoglobin S- Deoxyhemoglobin S
- Deoxygenated Sickle Hemoglobin
- Hemoglobin, Deoxygenated Sickle
- Sickle Hemoglobin, Deoxygenated
|
Below are MeSH descriptors whose meaning is more general than "Hemoglobin, Sickle".
Below are MeSH descriptors whose meaning is more specific than "Hemoglobin, Sickle".
This graph shows the total number of publications written about "Hemoglobin, Sickle" by people in this website by year, and whether "Hemoglobin, Sickle" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hemoglobin, Sickle" by people in Profiles.
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Allele-Specific Recombinase Polymerase Amplification to Detect Sickle Cell Disease in Low-Resource Settings. Anal Chem. 2021 03 23; 93(11):4832-4840.
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A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease. N Engl J Med. 2019 08 08; 381(6):509-519.
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Comparison of pneumococcal vaccination response in children with sickle cell disease: HbSS and HbSC. Allergol Immunopathol (Madr). 2019 Nov - Dec; 47(6):564-569.
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A Paper-Based Test for Screening Newborns for Sickle Cell Disease. Sci Rep. 2017 04 03; 7:45488.
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Sickle solubility test to screen for sickle cell trait: what's the harm? Hematology Am Soc Hematol Educ Program. 2015; 2015:433-5.
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Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. N Engl J Med. 2014 Aug 21; 371(8):699-710.
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A prospective newborn screening and treatment program for sickle cell anemia in Luanda, Angola. Am J Hematol. 2013 Dec; 88(12):984-9.
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Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis. Lancet Infect Dis. 2012 Jun; 12(6):457-68.
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Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood. 2012 Apr 19; 119(16):3684-90.
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Free heme and the polymerization of sickle cell hemoglobin. Biophys J. 2010 Sep 22; 99(6):1976-85.