"Methacholine Chloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
| Descriptor ID |
D016210
|
| MeSH Number(s) |
D02.092.877.883.555.500 D02.675.276.534.500
|
| Concept/Terms |
Methacholine Chloride- Methacholine Chloride
- Chloride, Methacholine
- Acetyl-beta-methacholine Chloride
- Acetyl beta methacholine Chloride
- Mecholine
- 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
- Acetyl-2-methylcholine Chloride
- Acetyl 2 methylcholine Chloride
|
Below are MeSH descriptors whose meaning is more general than "Methacholine Chloride".
Below are MeSH descriptors whose meaning is more specific than "Methacholine Chloride".
This graph shows the total number of publications written about "Methacholine Chloride" by people in this website by year, and whether "Methacholine Chloride" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 2 | 2 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Methacholine Chloride" by people in Profiles.
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Association of methacholine challenge test with diagnosis of chronic lung allograft dysfunction in lung transplant patients. Clin Transplant. 2018 10; 32(10):e13397.
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Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15; 309(10):L1174-85.
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The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun. 2015 Feb 17; 6:6281.
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Effects of sex hormones on bronchial reactivity during the menstrual cycle. BMC Pulm Med. 2014 Jul 01; 14:108.
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Variability of methacholine bronchoprovocation and the effect of inhaled corticosteroids in mild asthma. Ann Allergy Asthma Immunol. 2014 Apr; 112(4):354-60.e1.
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Airways in smooth muscle a-actin null mice experience a compensatory mechanism that modulates their contractile response. J Appl Physiol (1985). 2012 Mar; 112(5):898-903.
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Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2435-40.
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H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008 Oct 24; 322(5901):587-90.
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Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther. 2008; 21(1):115-24.
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Commentary on "restrained whole body plethysmography for measure of strain-specific and allergen-induced airway responsiveness in conscious mice". J Appl Physiol (1985). 2007 Jun; 102(6):2411; author reply 2412-3.