"Trimetrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Descriptor ID |
D016597
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| MeSH Number(s) |
D03.633.100.786.925
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trimetrexate".
Below are MeSH descriptors whose meaning is more specific than "Trimetrexate".
This graph shows the total number of publications written about "Trimetrexate" by people in this website by year, and whether "Trimetrexate" was a major or minor topic of these publications.
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Below are the most recent publications written about "Trimetrexate" by people in Profiles.
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Emax model and interaction index for assessing drug interaction in combination studies. Front Biosci (Elite Ed). 2010 01 01; 2(2):582-601.
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Applying Emax model and bivariate thin plate splines to assess drug interactions. Front Biosci (Elite Ed). 2010 01 01; 2(1):279-92.
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Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15; 20(12):2876-80.
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Characterization of cross-resistance to methotrexate in a human breast cancer cell line selected for resistance to melphalan. Biochem Pharmacol. 1995 Apr 18; 49(8):1069-78.
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Mechanism of acquired resistance to methotrexate in P388 murine leukemia cells and in their doxorubicin-resistant subline. Isr J Med Sci. 1988 Sep-Oct; 24(9-10):477-82.
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Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome. Antimicrob Agents Chemother. 1988 Mar; 32(3):324-6.
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Pharmacokinetics of trimetrexate (NSC 352122) in monkeys. Cancer Res. 1986 Jan; 46(1):169-74.