Receptor, Interferon alpha-beta
"Receptor, Interferon alpha-beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.
| Descriptor ID |
D053633
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| MeSH Number(s) |
D12.776.543.750.705.852.400.500
|
| Concept/Terms |
Receptor, Interferon alpha-beta- Receptor, Interferon alpha-beta
- Receptor, Interferon alpha beta
- IFN-alphaR
- Interferon alpha Receptor
- alpha Receptor, Interferon
- Type I Interferon Receptor
- Interferon alpha-beta Receptor
- Interferon alpha beta Receptor
- Interferon alphabeta Receptors
- Receptors, Interferon alphabeta
- Receptor, Interferon alpha
- IFN-alphabetaR
- IFN alphabetaR
- Interferon alpha Receptors
- Receptors, Interferon alpha
- alpha Receptors, Interferon
Interferon alpha-beta Receptor Chain 2- Interferon alpha-beta Receptor Chain 2
- Interferon alpha beta Receptor Chain 2
- Interferon alpha-beta Receptor IFNAR2 Subunit
- Interferon alpha beta Receptor IFNAR2 Subunit
- Interferon alpha-beta Receptor-2
- Interferon alpha beta Receptor 2
- Receptor-2, Interferon alpha-beta
- alpha-beta Receptor-2, Interferon
- IFNAR2 Subunit, Interferon alpha-beta Receptor
- IFNAR2 Subunit, Interferon alpha beta Receptor
Interferon alpha-beta Receptor Chain 1- Interferon alpha-beta Receptor Chain 1
- Interferon alpha beta Receptor Chain 1
- Interferon alpha-beta Receptor IFNAR1 Subunit
- Interferon alpha beta Receptor IFNAR1 Subunit
- Interferon alpha-beta Receptor-1
- Interferon alpha beta Receptor 1
- Receptor-1, Interferon alpha-beta
- alpha-beta Receptor-1, Interferon
- IFNAR1 Subunit, Interferon alpha-beta Receptor
- IFNAR1 Subunit, Interferon alpha beta Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptor, Interferon alpha-beta".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Interferon alpha-beta".
This graph shows the total number of publications written about "Receptor, Interferon alpha-beta" by people in this website by year, and whether "Receptor, Interferon alpha-beta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2010 | 1 | 2 | 3 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 1 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, Interferon alpha-beta" by people in Profiles.
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An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer Cell. 2019 01 14; 35(1):33-45.e6.
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An Immunocompetent Mouse Model of Zika Virus Infection. Cell Host Microbe. 2018 05 09; 23(5):672-685.e6.
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Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell. 2016 May 19; 165(5):1081-1091.
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Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Rep. 2016 Apr 05; 15(1):171-180.
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BRAF Inhibitors and IFNa: Plus, Minus, or Indeterminate? J Natl Cancer Inst. 2016 Jul; 108(7).
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Type I interferons mediate pancreatic toxicities of PERK inhibition. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15420-5.
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STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15408-13.
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Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun. 2015 May 08; 6:7089.
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Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways. PLoS One. 2015; 10(3):e0120274.
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Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):19226-31.