"Mecamylamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Descriptor ID |
D008464
|
| MeSH Number(s) |
D02.455.849.575.781.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Mecamylamine".
Below are MeSH descriptors whose meaning is more specific than "Mecamylamine".
This graph shows the total number of publications written about "Mecamylamine" by people in this website by year, and whether "Mecamylamine" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mecamylamine" by people in Profiles.
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Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake. PLoS One. 2016; 11(3):e0150270.
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Topical mecamylamine for diabetic macular edema. Am J Ophthalmol. 2010 May; 149(5):839-51.e1.
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Potentiated startle as a measure of the negative affective consequences of repeated exposure to nicotine in rats. Psychopharmacology (Berl). 2009 Nov; 207(1):13-25.
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Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit. Neuropharmacology. 2007 Dec; 53(7):863-9.
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Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. J Neurosci. 2004 Nov 10; 24(45):10035-9.
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Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine. Lab Invest. 2003 Feb; 83(2):207-25.
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Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors. Am J Physiol Regul Integr Comp Physiol. 2001 Oct; 281(4):R1105-13.
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Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology. 2001 Aug; 95(2):525-30.
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Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity. Neuron. 2001 Jul 19; 31(1):131-41.
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Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization. J Pharmacol Exp Ther. 2000 Oct; 295(1):58-66.