"Photobleaching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Light-induced change in a chromophore, resulting in the loss of its absorption of light of a particular wave length. The photon energy causes a conformational change in the photoreceptor proteins affecting PHOTOTRANSDUCTION. This occurs naturally in the retina (ADAPTATION, OCULAR) on long exposure to bright light. Photobleaching presents problems when occurring in PHOTODYNAMIC THERAPY, and in FLUORESCENCE MICROSCOPY. On the other hand, this phenomenon is exploited in the technique, FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING, allowing measurement of the movements of proteins and LIPIDS in the CELL MEMBRANE.
| Descriptor ID |
D038761
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| MeSH Number(s) |
G02.740.680
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Photobleaching".
Below are MeSH descriptors whose meaning is more specific than "Photobleaching".
This graph shows the total number of publications written about "Photobleaching" by people in this website by year, and whether "Photobleaching" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Photobleaching" by people in Profiles.
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High rates of virus-induced gene silencing by tobacco rattle virus in Populus. Tree Physiol. 2015 Sep; 35(9):1016-29.
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Validating pharmacological disruption of protein-protein interactions by acceptor photobleaching FRET imaging. Methods Mol Biol. 2013; 986:165-78.
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The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini. Neuron. 2012 Apr 26; 74(2):344-60.
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Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture. Cell. 2012 Mar 02; 148(5):1029-38.
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Improved method for counting DNA molecules on biofunctionalized nanoparticles. Langmuir. 2010 Feb 02; 26(3):1594-7.
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The M3/M4 cytoplasmic loop of the alpha1 subunit restricts GABAARs lateral mobility: a study using fluorescence recovery after photobleaching. Cell Motil Cytoskeleton. 2006 Dec; 63(12):747-57.
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Inactivating Pit-1 mutations alter subnuclear dynamics suggesting a protein misfolding and nuclear stress response. J Cell Biochem. 2004 Jul 01; 92(4):664-78.
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Photobleaching-corrected FRET efficiency imaging of live cells. Biophys J. 2004 Jun; 86(6):3923-39.